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p-5S-YAP1 [cytosol]
Stable Identifier
R-HSA-2028554
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p5-YAP1, pentaphospho-YAP1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hippo (Homo sapiens)
Phosphorylation of YAP by LATS1 (Homo sapiens)
p-5S-YAP1 [cytosol] (Homo sapiens)
YWHAB (14-3-3 beta/alpha) dimer binds phosphorylated YAP1 (Homo sapiens)
p-YAP1 [cytosol] (Homo sapiens)
p-5S-YAP1 [cytosol] (Homo sapiens)
p-YAP1:YWHAB [cytosol] (Homo sapiens)
p-YAP1 [cytosol] (Homo sapiens)
p-5S-YAP1 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
18158288
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
Cheung, K
,
Rashidi, B
,
Yang, X
,
Hao, Y
,
Chun, A
J Biol Chem
2008
External Reference Information
External Reference
UniProt:P46937 YAP1
Gene Names
YAP1, YAP65
Chain
chain:1-504
Reference Genes
BioGPS Gene:10413 YAP1
COSMIC (genes):YAP1 YAP1
CTD Gene:10413 YAP1
dbSNP Gene:10413 YAP1
ENSEMBL:ENSG00000137693 YAP1
ENSEMBL_homo_sapiens_GENE:ENSG00000137693.14 YAP1
HGNC:16262 YAP1
KEGG Gene (Homo sapiens):10413 YAP1
Monarch:10413 YAP1
NCBI Gene:10413 YAP1
OMIM:606608 YAP1
UCSC:P46937 YAP1
Reference Transcript
RefSeq:NM_001282097.1 YAP1
RefSeq:NM_001282098.1 YAP1
RefSeq:NM_001282100.1 YAP1
RefSeq:NM_001282099.1 YAP1
RefSeq:NM_001282101.1 YAP1
RefSeq:NM_001130145.2 YAP1
RefSeq:NM_001195044.1 YAP1
RefSeq:NM_001195045.1 YAP1
Other Identifiers
10413
11717920_a_at
11717921_x_at
11717922_a_at
11717923_s_at
11717924_a_at
11717925_s_at
11740548_a_at
11746496_a_at
16730503
213342_PM_at
213342_at
224894_PM_at
224894_at
224895_PM_at
224895_at
2929983
3346452
3346454
3346455
3346456
3346457
3346458
3346460
3346461
3346468
3346479
3346489
3346492
3346498
3346504
3346508
3346509
3346510
37979_at
46314_at
7943398
A_14_P102030
A_23_P104762
A_24_P273679
GE60063
GO:0000122
GO:0000902
GO:0000976
GO:0000978
GO:0001570
GO:0001674
GO:0001824
GO:0001829
GO:0001894
GO:0002067
GO:0003013
GO:0003015
GO:0003143
GO:0003677
GO:0003682
GO:0003713
GO:0003714
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005829
GO:0005911
GO:0006351
GO:0006355
GO:0006974
GO:0008283
GO:0008284
GO:0010468
GO:0010628
GO:0010629
GO:0010837
GO:0012501
GO:0016020
GO:0023052
GO:0030054
GO:0030154
GO:0030216
GO:0030307
GO:0030857
GO:0030859
GO:0030903
GO:0032570
GO:0033148
GO:0035019
GO:0035265
GO:0035329
GO:0042060
GO:0042127
GO:0043226
GO:0044782
GO:0045599
GO:0045669
GO:0045747
GO:0045893
GO:0045944
GO:0046622
GO:0048339
GO:0048368
GO:0048856
GO:0050673
GO:0050679
GO:0050767
GO:0050847
GO:0060045
GO:0060070
GO:0060242
GO:0060449
GO:0060487
GO:0060575
GO:0060576
GO:0060828
GO:0061026
GO:0065003
GO:0070064
GO:0070102
GO:0070161
GO:0071300
GO:0071480
GO:0072091
GO:0072307
GO:0090263
GO:0097191
GO:0140110
GO:0140297
GO:0140552
GO:1900182
GO:1902018
GO:1902459
GO:1903703
GO:1904036
GO:2000737
GO:2001237
HMNXSV003031607
Hs.84520.0.S1_3p_at
Hs.84520.0.S2_3p_at
Hs.8939.0.A2_3p_at
ILMN_1709479
PH_hs_0022813
TC11000954.hg
X80507_at
Participates
as a member of
p-YAP1 [cytosol] (Homo sapiens)
as an output of
Phosphorylation of YAP by LATS1 (Homo sapiens)
Other forms of this molecule
p-Y407-YAP1 [cytosol]
p-S127-YAP1 [cytosol]
p-Y407-YAP1 [nucleoplasm]
p-Y-YAP1 [cytosol]
p-Y-YAP1 [nucleoplasm]
YAP1 [cytosol]
YAP1 [nucleoplasm]
Inferred To
phospho-yap1 [cytosol]
(Danio rerio)
phospho-yap1 [cytosol]
(Xenopus tropicalis)
phospho-YAP1 [cytosol]
(Bos taurus)
phospho-YAP1 [cytosol]
(Canis familiaris)
phospho-YAP1 [cytosol]
(Sus scrofa)
phospho-yap-1 [cytosol]
(Caenorhabditis elegans)
phospho-Yap1 [cytosol]
(Mus musculus)
phospho-Yap1 [cytosol]
(Rattus norvegicus)
phospho-p-5S-YAP1 [cytosol]
(Gallus gallus)
Modified Residues
Name
O-phospho-L-serine at 61
Coordinate
61
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 109
Coordinate
109
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 127
Coordinate
127
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 164
Coordinate
164
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 397
Coordinate
397
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001269029.1
,
NP_001269026.1
,
NP_001269027.1
,
NP_001181974.1
,
NP_001181973.1
,
NP_001123617.1
,
NP_001269028.1
,
NP_001269030.1
OpenTargets
ENSG00000137693
GeneCards
P46937
HPA
ENSG00000137693-YAP1
Ensembl
ENSP00000434134
,
ENSP00000487519
,
ENSP00000445635
,
ENSP00000478927
,
ENSP00000431574
,
ENST00000615667
,
ENST00000629586
,
ENST00000524575
,
ENST00000537274
,
ENST00000282441
,
ENST00000531439
,
ENSG00000137693
,
ENST00000345877
,
ENST00000526343
,
ENSP00000435602
,
ENSP00000331023
,
ENSP00000282441
PRO
P46937
Pharos - Targets
P46937
Orphanet
22672
PDB
3KYS
,
6HIK
,
6GE5
,
2LTV
,
6G8I
,
6GE6
,
2LTW
,
6GEK
,
6G8Q
,
5YDY
,
6GEI
,
2LAY
,
6GE3
,
1K9Q
,
1K5R
,
3MHR
,
6GEG
,
6GE4
,
5OAQ
,
1K9R
,
6GEE
,
7O07
,
2LAW
,
6G8L
,
6GEC
,
6G8P
,
8C2F
,
2LAX
,
5YDX
,
6Q2X
,
4RE1
,
1JMQ
,
4REX
,
6G6X
,
6G8J
,
8A8R
,
6HIL
,
6G8K
,
8A8Q
Interactors (52)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28347 TEAD1
1
TEAD1 [nucleoplasm]
(R-HSA-2032774)
0.94
11
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.908
10
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.906
9
UniProt:Q15561 TEAD4
1
TEAD4 [nucleoplasm]
(R-HSA-2032780)
0.897
12
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.894
11
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.894
9
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.882
11
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.881
14
UniProt:O95835 LATS1
2
LATS1 [cytosol]
(R-HSA-2028562)
p-S909,T1079-LATS1 [cytosol]
(R-HSA-2028551)
0.88
10
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.842
9
UniProt:Q15562 TEAD2
1
TEAD2 [nucleoplasm]
(R-HSA-2032763)
0.823
9
UniProt:Q9BZD6 TMG4
0.815
5
UniProt:Q15678 PTPN14
1
PTPN14 [nucleoplasm]
(R-HSA-9008917)
0.813
8
UniProt:Q15599 NHRF2
0.809
6
UniProt:Q4VCS5 AMOT
0.802
6
UniProt:Q969T9 WBP2
0.759
7
UniProt:O14745 NHRF1
0.753
9
UniProt:P97764 WBP1
0.74
13
UniProt:O15350 TP73
3
PolyUb-TP73 [cytosol]
(R-HSA-8957256)
TP73 [cytosol]
(R-HSA-8957239)
TP73 [nucleoplasm]
(R-HSA-6798094)
0.73
5
UniProt:O15105 SMAD7
2
SMAD7 [nucleoplasm]
(R-HSA-178197)
SMAD7 [cytosol]
(R-HSA-173478)
0.715
7
UniProt:Q99594 TEAD3
1
TEAD3 [nucleoplasm]
(R-HSA-2032767)
0.68
5
UniProt:O75970 MPDZ
0.671
5
UniProt:Q8IY63 AMOTL1
1
AMOTL1 [cytosol]
(R-HSA-2028603)
0.671
5
UniProt:Q9Y2J4 AMOTL2
1
AMOTL2 [cytosol]
(R-HSA-2028606)
0.671
5
UniProt:Q13625 TP53BP2
1
TP53BP2 [nucleoplasm]
(R-HSA-6799780)
0.671
5
UniProt:Q8N3R9 MPP5
2
MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9689606)
MPP5 [plasma membrane]
(R-HSA-419969)
0.671
5
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.659
3
UniProt:O14669 TMG2
0.658
5
UniProt:O15350-1 TP73
0.65
7
UniProt:Q92841 DDX17
2
DDX17 [nucleoplasm]
(R-HSA-3900090)
monoSUMO1-K50-DDX17 [nucleoplasm]
(R-HSA-3900104)
0.649
7
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.643
3
UniProt:Q96G27 WBP1
0.623
4
UniProt:Q9P2Y5 UVRAG
2
UVRAG [cytosol]
(R-HSA-5668884)
UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9730510)
0.623
2
UniProt:Q96PN7 TREF1
0.623
2
UniProt:Q13625-2 TP53BP2
0.618
9
UniProt:Q9H3D4 TP63
1
TP63 [nucleoplasm]
(R-HSA-2997585)
0.609
2
UniProt:Q8NI35 PATJ
1
PATJ [plasma membrane]
(R-HSA-420011)
0.569
4
UniProt:Q13131 PRKAA1
3
p-T183-PRKAA1 [cytosol]
(R-HSA-380964)
PRKAA1 [cytosol]
(R-HSA-380935)
p-T183-PRKAA1 [nucleoplasm]
(R-HSA-2151206)
0.564
3
UniProt:Q99593 TBX5
1
TBX5 [nucleoplasm]
(R-HSA-2032786)
0.558
4
UniProt:Q15562-2 TEAD2
0.556
3
UniProt:Q02750 MAP2K1
20
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
MAP2K1 Q56P [cytosol]
(R-HSA-9652064)
MAP2K1 E203K [cytosol]
(R-HSA-9652023)
MAP2K1 V60E [cytosol]
(R-HSA-9652067)
MAP2K1 P124S [cytosol]
(R-HSA-9652062)
MAP2K1 Y130C [cytosol]
(R-HSA-9652101)
MAP2K1 C121S [cytosol]
(R-HSA-9652013)
MAP2K1 G128V [cytosol]
(R-HSA-9652047)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 L42_K57del [cytosol]
(R-HSA-9652026)
0.556
3
UniProt:Q15797 SMAD1
4
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
SMAD1 [cytosol]
(R-HSA-201468)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
0.544
3
UniProt:Q9NUP9 LIN7C
2
LIN7C [plasma membrane]
(R-HSA-5216165)
LIN7C [transport vesicle membrane]
(R-HSA-9610411)
0.527
3
UniProt:Q9Y4G8 RAPGEF2
1
RAPGEF2 [cytosol]
(R-HSA-5672599)
0.527
2
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.527
2
UniProt:A6NKD9 CC85C
0.527
3
UniProt:P35240 NF2
1
NF2 [plasma membrane]
(R-HSA-5669168)
0.527
2
UniProt:O14544 SOCS6
1
SOCS6 [cytosol]
(R-HSA-1469969)
0.524
2
UniProt:O35625 Axin1
8
Phospho Axin1 [cytosol]
(R-MMU-206175)
Axin1 [cytosol]
(R-MMU-4641133)
phospho-Axin1 [cytosol]
(R-MMU-3640864)
phospho-Axin1 [cytosol]
(R-MMU-3640841)
Axin1 [cytosol]
(R-MMU-205727)
Phospho (3 sites) Axin1 [cytosol]
(R-MMU-205737)
phospho-Axin1 [cytosol]
(R-MMU-206040)
Axin1 [cytosol]
(R-MMU-195249)
0.524
3
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
AXIN1 [cytosol]
(R-HSA-195249)
0.499
11
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
2
IntAct:EBI-9253952 SUPER
0.462
3
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