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CYP8B1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-192012
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Cytochrome P450 8B1, CP8B_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Eicosanoids (Homo sapiens)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)
PTGIS,CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
Endogenous sterols (Homo sapiens)
Sterols are 12-hydroxylated by CYP8B1 (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)
CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)
CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)
PTGIS,CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (Homo sapiens)
CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7a,27DONE (Homo sapiens)
CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
CYP8B1 12-hydroxylates 4CHOL7aOLONE (Homo sapiens)
CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Nicotinate metabolism (Homo sapiens)
Nicotinamide salvaging (Homo sapiens)
PTGIS, CYP8A1 isomerise PGH2 to PGI2 (Homo sapiens)
PTGIS,CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UNU6 CYP8B1
Gene Names
CYP8B1, CYP12
Chain
chain:1-501
Reference Genes
BioGPS Gene:1582 CYP8B1
COSMIC (genes):CYP8B1 CYP8B1
CTD Gene:1582 CYP8B1
dbSNP Gene:1582 CYP8B1
ENSEMBL:ENSG00000180432 CYP8B1
HGNC:2653 CYP8B1
KEGG:hsa:1582 CYP8B1
Monarch:1582 CYP8B1
NCBI Gene:1582 CYP8B1
OMIM:602172 CYP8B1
UCSC:Q9UNU6 CYP8B1
Reference Transcript
RefSeq:NM_004391.2 CYP8B1
Other Identifiers
11730157_at
1582
16952649
232494_PM_at
232494_at
2670970
2670976
2670977
2670978
45943_at
8086457
A_24_P208704
GE54759
GE556288
GO:0003824
GO:0004497
GO:0005506
GO:0005783
GO:0005789
GO:0006629
GO:0006694
GO:0006699
GO:0008397
GO:0016020
GO:0016125
GO:0016491
GO:0016705
GO:0019825
GO:0020037
GO:0031667
GO:0033778
GO:0033779
GO:0043226
GO:0045797
GO:0046872
GO:0070723
HMNXSV003012808
Hs.35718.0.S1_3p_at
ILMN_1669802
PH_hs_0026172
TC03001328.hg
TC03001329.hg
Participates
as a candidate of
PTGIS,CYP8B1 [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
CYP8B1 [endoplasmic reticulum membrane]
(Canis familiaris)
CYP8B1 [endoplasmic reticulum membrane]
(Danio rerio)
CYP8B1 [endoplasmic reticulum membrane]
(Mus musculus)
CYP8B1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
CYP8B1 [endoplasmic reticulum membrane]
(Sus scrofa)
CYP8B1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
1357
ENSEMBL
ENSP00000318867
,
ENST00000316161
OpenTargets
ENSG00000180432
IntEnz
1.14.14.139
HPA
ENSG00000180432-CYP8B1
PRO
Q9UNU6
Pharos - Targets
Q9UNU6
HMDB Protein
HMDBP06125
PDB
8EOH
,
7LYX
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15034 HERC3
1
HERC3 [cytosol]
(R-HSA-8851651)
0.527
2
UniProt:P09758 TACD2
0.527
2
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
2
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