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CUL4B [nucleoplasm]
Stable Identifier
R-HSA-975973
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cullin-4B, CUL4B_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Damage Bypass (Homo sapiens)
Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
UV-DDB ubiquitinates XPC (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
UV-DDB:COP9 Signalosome [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Dual Incision in GG-NER (Homo sapiens)
3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Formation of Incision Complex in GG-NER (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Homo sapiens)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
CHD1L is recruited to GG-NER site (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Formation of the pre-incision complex in GG-NER (Homo sapiens)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Recruitment of XPA and release of CAK (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
SUMOylation of XPC (Homo sapiens)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
TFIIH binds GG-NER site to form a verification complex (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
PAR-UV-DDB [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
ERCC5 and RPA bind TC-NER site (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
RBX1:CUL4:DDB1:DCAFs [nucleoplasm] (Homo sapiens)
CUL4 [nucleoplasm] (Homo sapiens)
CUL4B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13620 CUL4B
Gene Names
CUL4B, KIAA0695
Chain
chain:1-913
Reference Genes
BioGPS Gene:8450 CUL4B
COSMIC (genes):CUL4B CUL4B
CTD Gene:8450 CUL4B
dbSNP Gene:8450 CUL4B
ENSEMBL:ENSG00000158290 CUL4B
ENSEMBL_homo_sapiens_GENE:ENSG00000158290 CUL4B
HGNC:2555 CUL4B
KEGG Gene (Homo sapiens):8450 CUL4B
Monarch:8450 CUL4B
NCBI Gene:8450 CUL4B
OMIM:300304 CUL4B
UCSC:Q13620 CUL4B
Reference Transcript
RefSeq:XM_011531400.2 CUL4B
RefSeq:NM_003588.3 CUL4B
RefSeq:NM_001079872.1 CUL4B
Other Identifiers
0005080047
11720094_a_at
11720095_a_at
11742846_a_at
11880
17113744
17786
202213_s_at
202214_s_at
210257_x_at
215997_s_at
2DO7
3046
40141_at
4019901
4019902
4019905
4019908
4019909
4019910
4019911
4019913
4019915
4019917
4019919
4019920
4019922
4019923
4019926
4019927
4019928
4019929
4019931
4019936
4019938
4019939
4019940
4019941
4019942
4019943
4019944
4019953
4019955
4A0C
4A0L
4A64
58979
8174794
8450
A6NE76
A_23_P148463
A_23_P422178
AAB67315
AAC50548
AAH36216
AAK16812
AAR13073
AB014595
AC002476
AF212995
AK123688
AK299081
AK315037
AL451005
AY365125
BAA31670
BAG37520
BAG53936
BAH12944
BC036216
BX537787
CAB017786
CAD97843
CCDS35379
CCDS43987
CH471107
CUL4B
CUL4B-202
CUL4B-204
EAX11877
ENSG00000158290
ENSP00000360373
ENSP00000384109
ENST00000371322
ENST00000404115
EntrezGene:8450
g13259126_3p_a_at
g13270466_3p_a_at
GE53396
GE563986
GO:0000082
GO:0000278
GO:0000715
GO:0003674
GO:0003677
GO:0003684
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006259
GO:0006281
GO:0006283
GO:0006293
GO:0006294
GO:0006296
GO:0006464
GO:0006511
GO:0006950
GO:0006974
GO:0007049
GO:0008150
GO:0009056
GO:0010498
GO:0016567
GO:0019899
GO:0022607
GO:0030154
GO:0031175
GO:0031461
GO:0031465
GO:0031625
GO:0032991
GO:0033683
GO:0034641
GO:0035518
GO:0042769
GO:0043226
GO:0043687
GO:0045732
GO:0048856
GO:0051276
GO:0065003
GO:0070062
GO:0070911
GO:0070914
GO:0080008
GO:1900087
HGNC:2555
HPA003046
HPA011880
HPA058979
Hs.155976.0.S1_3p_a_at
Hs.155976.2.S1_3p_a_at
ILMN_1691535
ILMN_2385161
IPR001373
IPR016157
IPR016158
IPR016159
IPR019559
IPR033044
IPR036317
IPR036388
IPR036390
K4DI93
MIM:300304
MIM:300354
NM_001079872
NM_001330624
NM_003588
NP_001073341
NP_001317553
NP_003579
PF00888
PF10557
PH_hs_0009400
SM00182
SM00884
TC0X001326.hg
U58091
U58091_at
uc004esv.4
uc004esw.4
UPI0000246E48
UPI000024704E
XM_005262481
XM_011531399
XM_011531400
XM_011531401
XP_005262538
XP_011529701
XP_011529702
XP_011529703
Participant Of
hasMember
CUL4 [nucleoplasm]
Other forms of this molecule
G76-NEDD8-K859-CUL4B [nucleoplasm]
Inferred To
CUL4B [nucleoplasm] (Arabidopsis thaliana)
CUL4B [nucleoplasm] (Bos taurus)
CUL4B [nucleoplasm] (Caenorhabditis elegans)
CUL4B [nucleoplasm] (Canis familiaris)
CUL4B [nucleoplasm] (Danio rerio)
CUL4B [nucleoplasm] (Dictyostelium discoideum)
CUL4B [nucleoplasm] (Drosophila melanogaster)
CUL4B [nucleoplasm] (Gallus gallus)
CUL4B [nucleoplasm] (Mus musculus)
CUL4B [nucleoplasm] (Oryza sativa)
CUL4B [nucleoplasm] (Rattus norvegicus)
CUL4B [nucleoplasm] (Saccharomyces cerevisiae)
CUL4B [nucleoplasm] (Schizosaccharomyces pombe)
CUL4B [nucleoplasm] (Sus scrofa)
CUL4B [nucleoplasm] (Taeniopygia guttata)
CUL4B [nucleoplasm] (Xenopus tropicalis)
Homologues of CUL4B [nucleoplasm] (Danio rerio)
Homologues of CUL4B [nucleoplasm] (Drosophila melanogaster)
Homologues of CUL4B [nucleoplasm] (Gallus gallus)
Homologues of CUL4B [nucleoplasm] (Sus scrofa)
Homologues of CUL4B [nucleoplasm] (Taeniopygia guttata)
Homologues of CUL4B [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
XP_011529702.1
,
NP_003579.3
,
NP_001073341.1
OpenTargets
ENSG00000158290
GeneCards
Q13620
DOCK Blaster
4A0L
,
4A0C
,
4A64
PRO
Q13620
Orphanet
15825
PDB
2DO7
,
4A0C
,
4A64
,
4A0L
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86VP6 CAND1
5
CAND1 [secretory granule lumen]
(R-HSA-6801390)
CAND1 [nucleoplasm]
(R-HSA-8955089)
CAND1 [extracellular region]
(R-HSA-6806498)
CAND1 [ficolin-1-rich granule lumen]
(R-HSA-6801399)
CAND1 [cytosol]
(R-HSA-5691146)
0.734
5
UniProt:P62877 RBX1
2
RBX1 [cytosol]
(R-HSA-180582)
RBX1 [nucleoplasm]
(R-HSA-1234142)
0.708
5
UniProt:Q15910 EZH2
1
EZH2 [nucleoplasm]
(R-HSA-212298)
0.597
15
UniProt:Q15022 SUZ12
2
SUMO1-K75-SUZ12 [nucleoplasm]
(R-HSA-4615932)
SUZ12 [nucleoplasm]
(R-HSA-212217)
0.597
13
UniProt:O94888 UBXN7
1
UBXN7 [cytosol]
(R-HSA-8956071)
0.564
3
UniProt:O75530 EED
1
EED [nucleoplasm]
(R-HSA-212278)
0.558
7
UniProt:Q08273
2
RBX1 [nucleoplasm]
(R-SCE-1234142)
RBX1 [cytosol]
(R-SCE-180582)
0.556
3
UniProt:Q92466 DDB2
3
DDB2 [nucleoplasm]
(R-HSA-53491)
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
0.527
3
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