Reactome | CUL4B [nucleoplasm]

CUL4B [nucleoplasm]

Stable Identifier

R-HSA-975973

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cullin-4B, CUL4B_HUMAN

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Damage Bypass (Homo sapiens)
  - Recognition of DNA damage by PCNA-containing replication complex (Homo sapiens)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Homo sapiens)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
        
        RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
        
        RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Homo sapiens)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
        
        RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Homo sapiens)
        
        RAD18:UBE2B,RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
        
        RBX1:CUL4:DDB1:DTL [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - DNA Damage Recognition in GG-NER (Homo sapiens)
      - PARP1 or PARP2 PARylates DDB2 and autoPARylates (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - PARP1 or PARP2 binds DDB2 at GG-NER site (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - UV-DDB ubiquitinates XPC (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
        
        UV-DDB:COP9 Signalosome [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB [nucleoplasm] (Homo sapiens)
        
        UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
    - Dual Incision in GG-NER (Homo sapiens)
      - 3'-incision of DNA by ERCC5 (XPG) in GG-NER (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER (Homo sapiens)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - CHD1L is recruited to GG-NER site (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - Formation of the pre-incision complex in GG-NER (Homo sapiens)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
        
        Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - Recruitment of XPA and release of CAK (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - TFIIH binds GG-NER site to form a verification complex (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Homo sapiens)
        
        Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        PAR-UV-DDB [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
    - Dual incision in TC-NER (Homo sapiens)
      - 3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
        
        TC-NER incision complex [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
        
        TC-NER incision complex [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
        
        TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - ERCC5 and RPA bind TC-NER site (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
    - Formation of TC-NER Pre-Incision Complex (Homo sapiens)
      - Assembly of the pre-incision complex in TC-NER (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - ERCC8 (CSA) binds stalled RNA Pol II (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
        
        TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
    - Recovery of RNA synthesis after TC-NER (Homo sapiens)
      - ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)
      - TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
        
        ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Homo sapiens)
        
        CUL4 [nucleoplasm] (Homo sapiens)
        
        CUL4B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13620 CUL4B

Gene Names

CUL4B, KIAA0695

Chain

chain:1-913

Reference Genes

BioGPS Gene:8450 CUL4B

COSMIC (genes):CUL4B CUL4B

CTD Gene:8450 CUL4B

dbSNP Gene:8450 CUL4B

ENSEMBL:ENSG00000158290 CUL4B

HGNC:2555 CUL4B

KEGG Gene (Homo sapiens):8450 CUL4B

Monarch:8450 CUL4B

NCBI Gene:8450 CUL4B

OMIM:300304 CUL4B

UCSC:Q13620 CUL4B

Reference Transcript

Other Identifiers

0005080047

11720094_a_at

11720095_a_at

11742846_a_at

17113744

202213_s_at

202214_s_at

210257_x_at

215997_s_at

40141_at

4019901

4019902

4019905

4019908

4019909

4019910

4019911

4019913

4019915

4019917

4019919

4019920

4019922

4019923

4019926

4019927

4019928

4019929

4019931

4019936

4019938

4019939

4019940

4019941

4019942

4019943

4019944

4019945

4019946

4019947

4019948

4019953

4019955

8174794

8450

A_23_P148463

A_23_P422178

GE53396

GE563986

GO:0000082

GO:0000278

GO:0000715

GO:0000717

GO:0003674

GO:0003677

GO:0003684

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006259

GO:0006281

GO:0006283

GO:0006293

GO:0006294

GO:0006295

GO:0006296

GO:0006464

GO:0006511

GO:0006950

GO:0006974

GO:0007049

GO:0008150

GO:0009056

GO:0010498

GO:0016567

GO:0019005

GO:0019899

GO:0022607

GO:0030154

GO:0031146

GO:0031175

GO:0031461

GO:0031465

GO:0031625

GO:0032991

GO:0033683

GO:0034641

GO:0035518

GO:0042254

GO:0042769

GO:0043161

GO:0043226

GO:0043687

GO:0045732

GO:0048856

GO:0051276

GO:0065003

GO:0070062

GO:0070911

GO:0070914

GO:0080008

GO:1900087

Hs.155976.0.S1_3p_a_at

Hs.155976.2.S1_3p_a_at

ILMN_1691535

ILMN_2385161

PH_hs_0009400

TC0X001326.hg

U58091_at

g13259126_3p_a_at

g13270466_3p_a_at

Participant Of

hasMember

CUL4 [nucleoplasm]

Other forms of this molecule

G76-NEDD8-K859-CUL4B [nucleoplasm]

Inferred To

pcu4 [nucleoplasm] (Schizosaccharomyces pombe)

cul-4 [nucleoplasm] (Caenorhabditis elegans)

culE [nucleoplasm] (Dictyostelium discoideum)

cul4b [nucleoplasm] (Danio rerio)

cul4b [nucleoplasm] (Xenopus tropicalis)

CUL4B [nucleoplasm] (Bos taurus)

CUL4B [nucleoplasm] (Canis familiaris)

CUL4B [nucleoplasm] (Gallus gallus)

CUL4B [nucleoplasm] (Plasmodium falciparum)

CUL4B [nucleoplasm] (Sus scrofa)

Cul4b [nucleoplasm] (Mus musculus)

Cul4b [nucleoplasm] (Rattus norvegicus)

culD [nucleoplasm] (Dictyostelium discoideum)

Cul4 [nucleoplasm] (Drosophila melanogaster)

Homologues of CUL4B [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_003579.3, NP_001073341.1, XP_011529702.1

OpenTargets

ENSG00000158290

HPA

ENSG00000158290-CUL4B

GeneCards

Q13620

Ensembl

ENSP00000360373, ENST00000404115, ENSP00000384109, ENSG00000158290, ENST00000371322

PRO

Q13620

Orphanet

15825

PDB

4A0L, 4A0C, 4A64, 2DO7

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86VP6 CAND1	5	CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [nucleoplasm] (R-HSA-8955089) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [cytosol] (R-HSA-5691146)	0.793	13
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.708	5
UniProt:Q92466 DDB2	3	DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654) PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035)	0.643	7
UniProt:Q15022 SUZ12	2	SUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932) SUZ12 [nucleoplasm] (R-HSA-212217)	0.597	13
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.597	15
UniProt:O94888 UBXN7	1	UBXN7 [cytosol] (R-HSA-8956071)	0.564	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.558	7
UniProt:Q08273	3	HRT1 [cytosol] (R-SCE-180582) HRT1 [cytosol] (R-SCE-8863132) HRT1 [nucleoplasm] (R-SCE-1234142)	0.556	3
UniProt:P38646 HSPA9	6	HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.527	2
UniProt:Q15843 NEDD8	17	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) K1881-CUL9-G76-NEDD8 [cytosol] (R-HSA-8955924) NEDD8 [nucleoplasm] (R-HSA-8955926) K705-CUL4A-G76-NEDD8 [nucleoplasm] (R-HSA-8952528) K859-CUL4B-G76-NEDD8 [nucleoplasm] (R-HSA-8952538) NEDD8(77-88) [cytosol] (R-HSA-6782654) NEDD8(1-88) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) K720-CUL1-G76-NEDD8 [cytosol] (R-HSA-8952534) K712-CUL3-G76-NEDD8 [cytosol] (R-HSA-8952531) K689-CUL2-G76-NEDD8 [cytosol] (R-HSA-8952526) K724-CUL5-G76-NEDD8 [cytosol] (R-HSA-8952018) NEDD8 [cytosol] (R-HSA-416969) K567-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419906) K556-TGFBR2-G76-NEDD8 [cytosol] (R-HSA-4419907) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.527	7
UniProt:P11142 HSPA8	10	HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2

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