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NUS1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-6806946
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
fullName evidence="8"Dehydrodolichyl diphosphate syntase complex subunit NUS1 ecNumber evidence="4"2.5.1.87/ecNumber, NGBR_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosylation precursor biosynthesis (Homo sapiens)
Defective DHDDS causes RP59 (Homo sapiens)
Defective DHDDS does not elongate E,E-FPP (Homo sapiens)
DHDDS K42E:NUS1 [endoplasmic reticulum membrane] (Homo sapiens)
NUS1 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Synthesis of Dolichyl-phosphate (Homo sapiens)
DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP (Homo sapiens)
DHDDS:NUS1 [endoplasmic reticulum membrane] (Homo sapiens)
NUS1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96E22 NUS1
Gene Names
NUS1, C6orf68, NGBR
Chain
chain:1-293
Reference Genes
BioGPS Gene:116150 NUS1
COSMIC (genes):NUS1 NUS1
CTD Gene:116150 NUS1
dbSNP Gene:116150 NUS1
ENSEMBL:ENSG00000153989 NUS1
HGNC:21042 NUS1
KEGG:hsa:116150 NUS1
Monarch:116150 NUS1
NCBI Gene:116150 NUS1
OMIM:610463 NUS1
UCSC:Q96E22 NUS1
Reference Transcript
RefSeq:NM_138459.3 NUS1
Other Identifiers
116150
11721509_s_at
11721510_x_at
11721511_at
11756080_s_at
11758846_x_at
17012079
215207_PM_x_at
215207_x_at
225070_PM_at
225070_at
225071_PM_at
225071_at
229640_PM_x_at
229640_x_at
2923061
2923062
2923063
2923064
2923065
2923066
2923067
2923069
2923070
2923071
2923072
2923073
2923074
2923075
2923076
2923077
2923078
2923091
3481220
3481223
3481224
3481226
3481227
3481228
3481232
3481719
3481721
3481722
3481723
3543689
4007109
4007111
4007112
4007113
4007114
48804_r_at
49193_at
56355_at
69192_at
8121704
88783_at
A_14_P125570
A_23_P93082
A_24_P312058
GE477804
GE559488
GO:0001525
GO:0003824
GO:0004659
GO:0005515
GO:0005783
GO:0005789
GO:0006486
GO:0006489
GO:0006629
GO:0016020
GO:0016740
GO:0016765
GO:0019408
GO:0030154
GO:0032383
GO:0035268
GO:0038084
GO:0042632
GO:0043226
GO:0043536
GO:0045547
GO:0046872
GO:0051000
GO:0055092
GO:1904423
HMNXSV003019833
Hs.289008.0.A1_3p_a_at
Hs.289008.1.S1_3p_at
ILMN_1657022
ILMN_1675542
ILMN_1696946
ILMN_2089902
PH_hs_0034111
TC06000932.hg
Participates
as a component of
DHDDS K42E:NUS1 [endoplasmic reticulum membrane] (Homo sapiens)
DHDDS:NUS1 [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
nus1 [endoplasmic reticulum membrane]
(Danio rerio)
nus1 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
Tango14 [endoplasmic reticulum membrane]
(Drosophila melanogaster)
NUS1 [endoplasmic reticulum membrane]
(Bos taurus)
NUS1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
NUS1 [endoplasmic reticulum membrane]
(Canis familiaris)
NUS1 [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
NUS1 [endoplasmic reticulum membrane]
(Gallus gallus)
NUS1 [endoplasmic reticulum membrane]
(Mus musculus)
NUS1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
NUS1 [endoplasmic reticulum membrane]
(Sus scrofa)
Nus1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000368494
,
ENSP00000357480
OpenTargets
ENSG00000153989
HPA
ENSG00000153989-NUS1
PRO
Q96E22
Pharos - Targets
Q96E22
GlyGen
Q96E22
Orphanet
NUS1
HMDB Protein
HMDBP09222
PDB
7PAX
,
6Z1N
,
7PB1
,
7PB0
,
7PAY
,
6W2L
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.527
3
UniProt:P35414 APLNR
1
APLNR [plasma membrane]
(R-HSA-374259)
0.527
2
UniProt:Q9P296 C5AR2
1
C5AR2 [plasma membrane]
(R-HSA-964798)
0.527
2
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