Reactome | HBB [lysosomal lumen]

HBB [lysosomal lumen]

Stable Identifier

R-HSA-9625193

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Hemoglobin subunit beta, HBB_HUMAN

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Chaperone Mediated Autophagy (Homo sapiens)
  - HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal lumen] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        HBB [lysosomal lumen] (Homo sapiens)
  - HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal lumen] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        HBB [lysosomal lumen] (Homo sapiens)
    - HSPA8:Substrates for CMA [lysosomal lumen] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
        
        HBB [lysosomal lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P68871 HBB

Gene Names

HBB

Chain

initiator methionine:, chain:2-147, peptide:33-42, peptide:33-39

Reference Genes

BioGPS Gene:3043 HBB

COSMIC (genes):HBB HBB

CTD Gene:3043 HBB

dbSNP Gene:3043 HBB

ENSEMBL:ENSG00000244734 HBB

HGNC:4827 HBB

KEGG:hsa:3043 HBB

Monarch:3043 HBB

NCBI Gene:3043 HBB

OMIM:141900 HBB

UCSC:P68871 HBB

Reference Transcript

RefSeq:NM_000518.5 HBB

Other Identifiers

11715347_s_at

11715348_x_at

11753712_x_at

1562981_PM_at

1562981_at

16734838

16734840

209116_PM_x_at

209116_x_at

211696_PM_x_at

211696_x_at

217232_PM_x_at

217232_x_at

3043

31687_f_at

32052_at

3360402

3360403

3360404

3360405

3360406

3360407

3360408

3360409

3360410

3360411

3360412

3360413

3360414

3360422

7946033

A_23_P203558

A_33_P3289150

GE61327

GO:0003013

GO:0003014

GO:0003824

GO:0004601

GO:0005344

GO:0005515

GO:0005576

GO:0005615

GO:0005829

GO:0005833

GO:0007155

GO:0008217

GO:0015670

GO:0015671

GO:0016209

GO:0016491

GO:0019825

GO:0020037

GO:0030185

GO:0030492

GO:0031720

GO:0031721

GO:0031838

GO:0042542

GO:0042744

GO:0043226

GO:0045429

GO:0046872

GO:0070062

GO:0070293

GO:0070527

GO:0071682

GO:0072562

GO:0097746

GO:0098754

GO:0098869

GO:0140104

GO:1904724

GO:1904813

HMNXSV003004371

HMNXSV003017647

Hs.155376.1.A1_3p_s_at

Hs2.339844.1.S1_3p_at

ILMN_2100437

M25079_s_at

PH_hs_0029250

PH_hs_0031887

RNA146079|ribozyme_0_192

TC11001329.hg

TC11001330.hg

TC11003023.hg

U01317_cds6_at

g13549111_3p_at

g179408_3p_s_at

Participates

as a member of

Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

HBB [cytosol]

HBB [late endosome lumen]

HBB [extracellular region]

HBB [endocytic vesicle lumen]

HBB [ficolin-1-rich granule lumen]

HBB [tertiary granule lumen]

CO-H+-HBB [cytosol]

Cross References

RefSeq

NP_000509.1

ENSEMBL

ENSG00000244734, ENSP00000494175, ENST00000335295, ENSP00000333994, ENST00000647020

OpenTargets

ENSG00000244734

HPA

ENSG00000244734-HBB

GeneCards

HBB

PRO

P68871

Pharos - Targets

P68871

GlyGen

P68871

Orphanet

HBB

HMDB Protein

HMDBP01625

PDB

6LCX, 1ABY, 1YHE, 1QSH, 5SW7, 1M9P, 4FC3, 6KAQ, 8WJ2, 3HHB, 6BWU, 6BNR, 1Y5F, 1RQ4, 3KMF, 1Y4G, 6L5X, 7DY3, 2M6Z, 7AET, 4N7N, 2H35, 6KAE, 1Y0C, 1YVT, 1Y4Q, 1A01, 5UFJ, 4WJG, 4ROL, 7UF7, 1Y45, 1NEJ, 1HGC, 1XY0, 1BZZ, 1LFY, 1Y7Z, 1YGD, 1XZ2, 7VDE, 1Y85, 1QSI, 9AV9, 6BB5, 8WJ1, 1J40, 9FHB, 4XS0, 1O1O, 1RPS, 1O1L, 7DY4, 1YDZ, 1RQA, 1CBL, 1Y35, 3NL7, 1J3Y, 1YEQ, 6NBC, 1Y7G, 1Y0D, 1BZ0, 7JY1, 3DUT, 1Y4R, 1GLI, 7UF6, 1Y46, 1HHO, 1HAB, 3IC0, 6KA9, 1Y7C, 1Y0W, 3NMM, 1LFZ, 6KAO, 6KAT, 3ONZ, 2D5Z, 2D60, 1J41, 1VWT, 1Y31, 1Y5J, 6BWP, 7PCF, 3ODQ, 1COH, 1XYE, 1J7W, 1BAB, 1G9V, 1CBM, 2HBC, 7PCQ, 1J7S, 1BIJ, 4N8T, 2YRS, 3HXN, 6XE7, 1DKE, 5NI1, 3QJE, 1YFF, 1XZ7, 1DXU, 1LFL, 5E6E, 1HAC, 3OO5, 5X2U, 1DXT, 1Y7D, 1Y09, 3D7O, 1R1X, 8FDK, 9FMU, 5KDQ, 6KAU, 7K4M, 3OO4, 2DN1, 1K0Y, 1O1P, 6NQ5, 4M4B, 2HBD, 1K1K, 4L7Y, 1A3N, 6L5Y, 8VYL, 1CMY, 1RVW, 7UVB, 1YH9, 1BZ1, 1QXD, 3QJD, 1YE0, 5X2S, 9AYZ, 1FN3, 4MQG, 7JY0, 5E83, 1HDB, 1SDK, 7CUE, 6L5V, 2HHB, 1YIE, 1XZU, 7UD7, 3S66, 1DXV, 2DN2, 6HK2, 1Y5K, 5KSI, 7PCH, 4M4A, 1O1M, 2HBE, 1GZX, 2W6V, 1YEU, 1Y2Z, 5WOG, 1A3O, 1J3Z, 1AJ9, 2DXM, 7XGY, 5URC, 1CLS, 1GBU, 7AEU, 1YE1, 1LFQ, 4MQC, 1C7B, 4NI1, 2HBS, 1IRD, 1A0U, 1O1I, 1R1Y, 8FDM, 1XZV, 3P5Q, 5HU6, 1YIH, 7JJQ, 8DOV, 6KAR, 2HHD, 4HHB, 1Y4V, 5JDO, 3QJC, 6KYE, 1O1N, 3B75, 2HBF, 8FDN, 1O1K, 1HBA, 3D17, 1YEN, 1THB, 1QXE, 4N7P, 1GBV, 1KD2, 1MKO, 6NBD, 1YE2, 5X2T, 1C7C, 1HGA, 4IJ2, 5UCU, 1YGF, 3SZK, 1LFT, 1O1J, 1QI8, 6DI4, 6LCW, 1ABW, 8FDL, 1Y8W, 2HCO, 6KAS, 2HHE, 2DN3, 1UIW, 8WJ0, 6TB2, 3QJB, 1J7Y, 6XD9, 5E29, 2W72, 1B86, 5KSJ, 3WCP, 1HBB, 5WOH, 3W4U, 7JXZ, 5VMM, 1XXT, 1YEO, 1Y0A, 1HCO, 1A00, 3S65, 6XDT, 1LJW, 6KAH, 7AEV, 1Y4B, 1YHR, 1XZ4, 8WXZ, 1C7D, 4MQI, 1Y0T, 1JY7, 1SDL, 4NI0, 1CH4, 6KAV, 6FQF, 1NIH, 1BUW, 3WHM, 3R5I, 1Y83, 4X0L, 1YZI, 5X2R, 1Y22, 6KAP, 1RQ3, 1NQP, 7UD8, 6HBW, 8EGI, 1Y4F, 1YEV, 6L5W, 1YVQ, 5EE4, 7JY3, 5U3I, 1A0Z, 1YG5, 1Y4P, 1BBB, 5HY8, 4N7O, 6KAI, 4ROM, 1HBS, 1HGB, 1XZ5, 4MQH, 3IC2, 6HAL, 1LFV

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P69905 HBA1	4	HBA1 [extracellular region] (R-HSA-2168862) HBA1 [endocytic vesicle lumen] (R-HSA-2230966) HBA1 [cytosol] (R-HSA-1008268) CO-H+-HBA1 [cytosol] (R-HSA-1237026)	0.971	32
UniProt:P02008 HBAZ			0.857	7
UniProt:Q9ULK0 GRID1			0.589	2
UniProt:Q6B0K9 HBM			0.556	3
UniProt:P09105 HBAT			0.556	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	2
UniProt:Q16659 MAPK6 gene	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.527	2
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.527	2
UniProt:Q6DKK2 TTC19	1	TTC19 [mitochondrial inner membrane] (R-HSA-9906047)	0.527	3
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.527	2
UniProt:P20933 AGA	2	AGA [extracellular region] (R-HSA-6806212) AGA [azurophil granule lumen] (R-HSA-6798769)	0.527	2
UniProt:Q9UNS2 COPS3	2	COPS3 [nucleoplasm] (R-HSA-5697017) COPS3 [cytosol] (R-HSA-416973)	0.527	2
UniProt:Q02383 SEMG2			0.527	2
UniProt:A2RU67 F234B			0.527	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	2
UniProt:Q9HBW0 LPAR2	1	LPAR2 [plasma membrane] (R-HSA-419393)	0.527	2
UniProt:Q6UXU6 TMM92			0.527	2
UniProt:P06899 H2BC11	9	HIST1H2BJ [nucleoplasm] (R-HSA-181900) Ub-121-HIST1H2BJ [nucleoplasm] (R-HSA-3364017) AcK13-HIST1H2BJ [nucleoplasm] (R-HSA-4568662) AcK16-HIST1H2BJ [nucleoplasm] (R-HSA-4568704) AcK6-HIST1H2BJ [nucleoplasm] (R-HSA-4568668) AcK21-HIST1H2BJ [nucleoplasm] (R-HSA-4568671) HIST1H2BJ [extracellular region] (R-HSA-977565) AcK-HIST1H2BJ [nucleoplasm] (R-HSA-4549258) Ub-HIST1H2BJ [nucleoplasm] (R-HSA-6782566)	0.527	2
UniProt:Q9NXJ5 PGPI			0.527	2
UniProt:Q5TEU4 NDUFAF5	1	NDUFAF5 [mitochondrial inner membrane] (R-HSA-5689127)	0.527	2
UniProt:P22003 BMP5			0.527	2
UniProt:P30711 GSTT1	1	GSTT1 [cytosol] (R-HSA-3302044)	0.527	2
UniProt:O15151 MDM4	5	MDM4 [nucleoplasm] (R-HSA-349430) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502)	0.527	3
UniProt:Q8TAC2 JOSD2	1	JOSD2 [cytosol] (R-HSA-5688775)	0.527	2
UniProt:O60759 CYTIP			0.527	2
UniProt:Q9HCI7 MSL2	1	MSL2 [nucleoplasm] (R-HSA-3321821)	0.527	2

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