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HBB [lysosomal lumen]
Stable Identifier
R-HSA-9625193
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
Hemoglobin subunit beta, HBB_HUMAN
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Chaperone Mediated Autophagy (Homo sapiens)
HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)
HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex [lysosomal lumen] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
HBB [lysosomal lumen] (Homo sapiens)
HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)
HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
LAMP2a multimer complex [lysosomal lumen] (Homo sapiens)
Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
HBB [lysosomal lumen] (Homo sapiens)
HSPA8:Substrates for CMA [lysosomal lumen] (Homo sapiens)
Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
HBB [lysosomal lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68871 HBB
Gene Names
HBB
Chain
initiator methionine:1, chain:2-147, peptide:33-42, peptide:33-39
Reference Genes
BioGPS Gene:3043 HBB
COSMIC (genes):HBB HBB
CTD Gene:3043 HBB
dbSNP Gene:3043 HBB
ENSEMBL:ENSG00000244734.4 HBB
HGNC:4827 HBB
KEGG Gene (Homo sapiens):3043 HBB
Monarch:3043 HBB
NCBI Gene:3043 HBB
OMIM:141900 HBB
UCSC:P68871 HBB
Reference Transcript
RefSeq:NM_000518.4 HBB
Other Identifiers
11715347_s_at
11715348_x_at
11753712_x_at
209116_PM_x_at
209116_x_at
211696_PM_x_at
211696_x_at
217232_PM_x_at
217232_x_at
3043
31687_f_at
32052_at
3360403
3360404
3360405
3360408
3360409
3360410
3360411
3360413
3360414
3360422
7946033
A_23_P203558
GE61327
GO:0003013
GO:0003014
GO:0003824
GO:0004601
GO:0005344
GO:0005515
GO:0005576
GO:0005615
GO:0005829
GO:0005833
GO:0007155
GO:0008217
GO:0010942
GO:0015670
GO:0015671
GO:0016209
GO:0016491
GO:0019825
GO:0020037
GO:0030185
GO:0030492
GO:0031410
GO:0031720
GO:0031721
GO:0031838
GO:0042060
GO:0042542
GO:0042744
GO:0043177
GO:0043226
GO:0045429
GO:0046872
GO:0070062
GO:0070293
GO:0070527
GO:0071682
GO:0072562
GO:0097746
GO:0098754
GO:0098869
GO:0140104
GO:1904724
GO:1904813
HMNXSV003017647
Hs.155376.1.A1_3p_s_at
ILMN_2100437
M25079_s_at
PH_hs_0029250
PH_hs_0031887
TC11001330.hg
TC11003023.hg
g13549111_3p_at
g179408_3p_s_at
Participates
as a member of
Substrates for chaperone mediated autophagy [lysosomal lumen] (Homo sapiens)
Other forms of this molecule
CO-H+-HBB [cytosol]
HBB [endocytic vesicle lumen]
HBB [tertiary granule lumen]
HBB [extracellular region]
HBB [ficolin-1-rich granule lumen]
HBB [late endosome lumen]
HBB [cytosol]
Cross References
RefSeq
NP_000509.1
OpenTargets
ENSG00000244734
GeneCards
P68871
HPA
ENSG00000244734-HBB
Ensembl
ENSP00000333994
,
ENST00000335295
,
ENST00000647020
,
ENSP00000494175
,
ENSG00000244734
PRO
P68871
Pharos - Targets
P68871
Orphanet
16186
HMDB Protein
HMDBP01625
PDB
1O1P
,
6BNR
,
1BIJ
,
3S66
,
2HBC
,
1Y0C
,
1BAB
,
1C7D
,
1RVW
,
1O1O
,
6L5V
,
1BZZ
,
1XYE
,
2HBS
,
4WJG
,
3IC2
,
7CUE
,
1XY0
,
4N7N
,
6L5W
,
1J40
,
3W4U
,
4N8T
,
1A0U
,
2HHD
,
1K0Y
,
6LCX
,
6BWU
,
1HAB
,
1Y4Q
,
1XZ5
,
1J41
,
3ONZ
,
1JY7
,
1DXT
,
1Y0D
,
3WCP
,
1O1L
,
6TB2
,
1DXU
,
1Y4B
,
7PCQ
,
1Y83
,
1Y85
,
2DN1
,
5X2U
,
1Y4F
,
5HY8
,
1G9V
,
1O1I
,
6LCW
,
7K4M
,
1HGC
,
2YRS
,
7AEU
,
2D5Z
,
6KAT
,
4M4A
,
1YIH
,
4NI0
,
1YHE
,
7JY1
,
3QJC
,
6KAU
,
1ABY
,
7PCH
,
3QJB
,
7AEV
,
1GBV
,
6FQF
,
5X2R
,
1IRD
,
3HXN
,
5JDO
,
2HBD
,
4ROM
,
1GZX
,
1YH9
,
1NIH
,
1Y2Z
,
6HBW
,
6KAO
,
3KMF
,
1LFZ
,
1YVT
,
3SZK
,
1YEU
,
4HHB
,
1YDZ
,
6KA9
,
7UF7
,
1YEV
,
1BZ1
,
4IJ2
,
6KAR
,
5VMM
,
1CMY
,
1Y45
,
3NL7
,
3OO4
,
6KAI
,
1GLI
,
4L7Y
,
6HK2
,
3B75
,
3ODQ
,
1RQ4
,
1HGB
,
1QXD
,
1COH
,
1AJ9
,
1K1K
,
6XD9
,
7DY3
,
4MQC
,
2W6V
,
1ABW
,
1Y4R
,
6HAL
,
2W72
,
1RQ3
,
5E6E
,
1XZ7
,
5KSJ
,
1YE2
,
1CBM
,
7JJQ
,
5KSI
,
1A01
,
1Y5K
,
5WOG
,
1LFQ
,
6XDT
,
1O1K
,
1R1X
,
3D17
,
5URC
,
6NBC
,
1GBU
,
2DN2
,
7VDE
,
2HCO
,
1Y22
,
3P5Q
,
8EGI
,
1SDK
,
1C7C
,
2DN3
,
1YEN
,
1J7Y
,
1Y5J
,
4MQH
,
1LFT
,
1SDL
,
6NBD
,
6NQ5
,
1YZI
,
1Y0A
,
1A3O
,
4MQG
,
1FN3
,
3S65
,
5EE4
,
4N7O
,
1DKE
,
1Y8W
,
1Y09
,
6L5X
,
1YHR
,
3IC0
,
6BWP
,
3QJE
,
1Y4P
,
5NI1
,
7JXZ
,
7AET
,
7JY0
,
1A00
,
1Y0T
,
2H35
,
1XZ4
,
1YE0
,
1O1N
,
1Y4G
,
6XE7
,
1O1M
,
1XZ2
,
4N7P
,
4ROL
,
1Y7Z
,
1HBB
,
1YGF
,
1LJW
,
5UFJ
,
5X2T
,
1BZ0
,
1HGA
,
3D7O
,
1BUW
,
1Y46
,
2DXM
,
7UF6
,
1YGD
,
1CH4
,
1QSH
,
2HBF
,
4NI1
,
6KAS
,
4M4B
,
3QJD
,
3NMM
,
1HDB
,
7PCF
,
1CBL
,
1J3Z
,
1Y7G
,
6KAV
,
1NQP
,
1C7B
,
2HBE
,
2D60
,
1CLS
,
3HHB
,
5X2S
,
1YIE
,
1YVQ
,
4XS0
,
1Y35
,
6KAP
,
1VWT
,
1LFY
,
1HHO
,
6KYE
,
1R1Y
,
6KAQ
,
7UD7
,
1Y31
,
1J3Y
,
7UD8
,
5UCU
,
5SW7
,
5U3I
,
1BBB
,
1Y7D
,
1HBS
,
1MKO
,
1YG5
,
2HHB
,
6KAE
,
1QSI
,
2M6Z
,
3WHM
,
5E29
,
1J7S
,
1A0Z
,
4X0L
,
1QI8
,
6BB5
,
1HAC
,
1O1J
,
6KAH
,
1RQA
,
7JY3
,
5KDQ
,
3OO5
,
1YFF
,
1NEJ
,
1Y7C
,
1HBA
,
4FC3
,
1DXV
,
1HCO
,
7DY4
,
1QXE
,
1Y0W
,
1LFL
,
1YE1
,
2HHE
,
1B86
,
1XXT
,
1RPS
,
5HU6
,
3R5I
,
1Y4V
,
1XZV
,
3DUT
,
6DI4
,
6L5Y
,
1YEO
,
7XGY
,
5E83
,
1YEQ
,
5WOH
,
1KD2
,
1Y5F
,
1M9P
,
1UIW
,
1THB
,
1LFV
,
1XZU
,
4MQI
,
1A3N
,
1J7W
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P69905 HBA1
4
CO-H+-HBA1 [cytosol]
(R-HSA-1237026)
HBA1 [cytosol]
(R-HSA-1008268)
HBA1 [endocytic vesicle lumen]
(R-HSA-2230966)
HBA1 [extracellular region]
(R-HSA-2168862)
0.967
29
UniProt:P02008 HBAZ
0.857
7
UniProt:Q6B0K9 HBM
0.556
3
UniProt:P09105 HBAT
0.556
3
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