Reactome | K63polyUb-K30,K401-IKBKE [cytosol]

K63polyUb-K30,K401-IKBKE [cytosol]

Stable Identifier

R-HSA-9730436

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
        
        Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation (Homo sapiens)
        
        IKKε (IKBKE) is ubiquitinated within the activated TLR3 complex (Homo sapiens)
        
        K63pUb-IKBKE:K63pUb-TANK:K63pUb-TRAF3:TICAM1:TLR3:viral dsRNA [endosome membrane] (Homo sapiens)
        
        K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Homo sapiens)
        
        K63polyUb-K30,K401-IKBKE [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) (Homo sapiens)
        
        Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 (Homo sapiens)
        
        IKKε (IKBKE) is ubiquitinated within the activated TLR4 (Homo sapiens)
        
        K63polyUb-IKBKE:K63polyUb-TANK:K63polyUb-TRAF3:TICAM1:TRAM:TLR4:LY96:LPS:CD14 [endosome membrane] (Homo sapiens)
        
        K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Homo sapiens)
        
        K63polyUb-K30,K401-IKBKE [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
23453972	Structure and ubiquitination-dependent activation of TANK-binding kinase 1 Hahn, WC, Li, Y, Zhu, Z, Marto, JA, Lee, KE, Yun, CH, Jeon, H, Tu, D, Eck, MJ, Chan, E, Zhou, AY, Thai, T, Ficarro, SB, Dunn, GP, Barbie, DA, Yang, S, Toms, AV	Cell Rep	2013

External Reference Information

External Reference

UniProt:Q14164 IKBKE

Gene Names

IKBKE, IKKE, IKKI, KIAA0151

Chain

chain:1-716

Reference Genes

BioGPS Gene:9641 IKBKE

COSMIC (genes):IKBKE IKBKE

CTD Gene:9641 IKBKE

dbSNP Gene:9641 IKBKE

ENSEMBL:ENSG00000263528 IKBKE

ENSEMBL_homo_sapiens_GENE:ENSG00000263528.8 IKBKE

HGNC:14552 IKBKE

KEGG Gene (Homo sapiens):9641 IKBKE

Monarch:9641 IKBKE

NCBI Gene:9641 IKBKE

OMIM:605048 IKBKE

UCSC:Q14164 IKBKE

Reference Transcript

Other Identifiers

11720956_a_at

11720957_a_at

16676592

204549_PM_at

204549_at

214398_PM_s_at

214398_s_at

2376798

2376800

2376801

2376802

2376807

2376808

2376809

2376810

2376812

2376816

2376817

2376818

2376820

2376821

2376822

2376823

2376824

2376825

2376826

2376830

2376831

2376832

2376833

2376835

2376836

2376837

2376838

2376839

2376840

33281_at

7909188

9641

A_23_P887

D63485_at

GE61317

GO:0000166

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006351

GO:0006355

GO:0006468

GO:0006955

GO:0006974

GO:0008384

GO:0008630

GO:0009967

GO:0010467

GO:0010628

GO:0010884

GO:0012501

GO:0016071

GO:0016301

GO:0016310

GO:0016605

GO:0016740

GO:0019903

GO:0023052

GO:0031625

GO:0031966

GO:0032481

GO:0034340

GO:0035456

GO:0036211

GO:0036435

GO:0042802

GO:0043123

GO:0043226

GO:0043254

GO:0048255

GO:0050896

GO:0051091

GO:0051607

GO:0060337

GO:0060340

GO:0065003

GO:0097400

GO:0098542

GO:0098586

GO:0140096

GO:1902554

HMNXSV003030390

HMNXSV003051390

Hs.321045.1.S1_3p_a_at

ILMN_1755024

PH_hs_0016042

TC01001723.hg

g7661945_3p_at

Participates

as a component of

K63polyUb-K30,K401-IKBKE homodimer [cytosol] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]

IKBKE [cytosol]

p-S172-IKBKE [cytosol]

p-S172-IKBKE [nucleoplasm]

Inferred To

Ikbke [cytosol] (Rattus norvegicus)

K63polyUb-K30,K401-IKBKE [cytosol] (Bos taurus)

K63polyUb-K30,K401-IKBKE [cytosol] (Canis familiaris)

K63polyUb-K30,K401-IKBKE [cytosol] (Gallus gallus)

K63polyUb-K30,K401-IKBKE [cytosol] (Mus musculus)

K63polyUb-K30,K401-IKBKE [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at 30

Coordinate

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at 401

Coordinate

401

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_054721.1, NP_001180251.1, XP_005273413.1, NP_001180250.1

ZINC - World Drugs

IKKE_HUMAN

Guide to Pharmacology - Targets

2040

OpenTargets

ENSG00000263528

ZINC - FDA approved

IKKE_HUMAN

ZINC - Substances

IKKE_HUMAN

ZINC - Biogenic

IKKE_HUMAN

ZINC target

Q14164

PRO

Q14164

ZINC - Investigational

IKKE_HUMAN

IntEnz

2.7.11.10

GeneCards

Q14164

HPA

ENSG00000263528-IKBKE

Ensembl

ENSP00000462396, ENST00000581977, ENSP00000464030, ENST00000584998, ENSG00000263528

Pharos - Targets

Q14164

ZINC - Predictions - Purchasable

IKKE_HUMAN

HMDB Protein

HMDBP09508

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.829	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.77	4
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.77	4
UniProt:A7MCY6 TBKB1			0.723	4
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.697	4
UniProt:P09936 UCHL1	1	UCHL1 [cytosol] (R-HSA-5660679)	0.675	4
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.669	3
UniProt:Q9UHD2 TBK1	5	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379)	0.669	5
UniProt:Q05127 VP35			0.602	3
UniProt:P60660 MYL6	2	p-S20-MYL6 [cytosol] (R-HSA-445778) MYL6 [cytosol] (R-HSA-419186)	0.589	2
UniProt:P06753 TPM3	3	TPM3 [cytosol] (R-HSA-390543) TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710837) TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710848)	0.589	2
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.589	2
UniProt:P62158 CALM			0.589	2
UniProt:Q00610 CLTC	10	CLTC [trans-Golgi network membrane] (R-HSA-5333703) CLTC [cytosol] (R-HSA-8856820) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC [plasma membrane] (R-HSA-2980668) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710835)	0.589	2
UniProt:P35580 MYH10	1	MYH10 [cytosol] (R-HSA-419174)	0.589	2
UniProt:P19105 MYL12A	2	p-S19-MYL12A [cytosol] (R-HSA-390749) MYL12A [cytosol] (R-HSA-390735)	0.589	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.589	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.564	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.564	2
UniProt:Q14653 IRF3	6	p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) IRF3(272-427) [cytosol] (R-HSA-9729737) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3 [cytosol] (R-HSA-166251)	0.544	2
UniProt:P27958-PRO_0000037572			0.524	2
UniProt:K7Y1A2 K7Y1A2			0.524	2
UniProt:Q92624 APBP2			0.499	4
UniProt:Q9BYX4 IFIH1	3	IFIH1 [cytosol] (R-HSA-913536) K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) PolyUb-IFIH1 [cytosol] (R-HSA-6782812)	0.499	2
UniProt:W5VXH5 W5VXH5			0.463	4
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.463	2

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