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DPH1 [cytosol]
Stable Identifier
R-HSA-5358384
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
diphthamide biosynthesis protein 1
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
Synthesis of diphthamide-EEF2 (Homo sapiens)
DPH2 transfers a 3-amino-3-carboxypropyl group from AdoMet to residue 715 of nascent EEF2 (Homo sapiens)
DPH1:DPH2:DPH3 [cytosol] (Homo sapiens)
DPH1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BZG8 DPH1
Gene Names
DPH1, DPH2L, DPH2L1, OVCA1
Chain
chain:1-438
Reference Genes
BioGPS Gene:1801 DPH1
COSMIC (genes):DPH1 DPH1
CTD Gene:1801 DPH1
dbSNP Gene:1801 DPH1
ENSEMBL:ENSG00000108963 DPH1
HGNC:3003 DPH1
Monarch:1801 DPH1
NCBI Gene:1801 DPH1
OMIM:603527 DPH1
UCSC:Q9BZG8 DPH1
Reference Transcript
RefSeq:NM_001346576.1 DPH1
RefSeq:NM_001383.4 DPH1
Other Identifiers
11716952_a_at
11733730_x_at
11747240_x_at
11756964_x_at
16829602
1801
202632_PM_at
202632_at
222041_PM_at
222041_at
3706075
3706076
3706078
3706079
3706080
3706081
3706082
3706083
3706084
3706085
3706086
3706087
3706088
3706089
3706090
3706091
3706092
3706093
3706094
3706095
3706096
3706097
3706098
3706099
3706100
3706101
3706102
3706103
3706104
3706105
3706106
3706107
3706108
3706109
3706110
3706111
3706112
3706114
38477_at
45444_at
8003700
87259_at
A_14_P109496
A_23_P118462
A_24_P202306
GE59101
GE870940
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0016740
GO:0017183
GO:0030054
GO:0043226
GO:0046872
GO:0048144
GO:0051536
GO:0051539
GO:0090560
GO:0120513
HMNXSV003016608
Hs.26034.0.A1_3p_at
ILMN_1677610
ILMN_1735573
PH_hs_0039631
TC17000018.hg
U34880_at
g4503360_3p_at
Participates
as a component of
DPH1:DPH2:DPH3 [cytosol] (Homo sapiens)
Inferred To
OVCA2 [cytosol]
(Canis familiaris)
Dph1 [cytosol]
(Drosophila melanogaster)
DPH1 [cytosol]
(Bos taurus)
DPH1 [cytosol]
(Caenorhabditis elegans)
DPH1 [cytosol]
(Danio rerio)
DPH1 [cytosol]
(Dictyostelium discoideum)
DPH1 [cytosol]
(Gallus gallus)
DPH1 [cytosol]
(Mus musculus)
DPH1 [cytosol]
(Plasmodium falciparum)
DPH1 [cytosol]
(Saccharomyces cerevisiae)
DPH1 [cytosol]
(Schizosaccharomyces pombe)
DPH1 [cytosol]
(Sus scrofa)
dph1 [cytosol]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSP00000501368
,
ENSP00000458726
,
ENSP00000263083
,
ENST00000263083
,
ENST00000674200
,
ENST00000570477
OpenTargets
ENSG00000108963
HPA
ENSG00000108963-DPH1
PRO
Q9BZG8
Pharos - Targets
Q9BZG8
Orphanet
DPH1
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.569
4
UniProt:Q9Y2G2 CARD8
1
CARD8 [cytosol]
(R-HSA-6805447)
0.527
2
UniProt:O75386 TULP3
1
TULP3 [cilium]
(R-HSA-5610445)
0.527
2
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