Reactome | SF3A3 [nucleoplasm]

SF3A3 [nucleoplasm]

Stable Identifier

R-HSA-71966

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SAP 61 (Splicing factor 3A subunit 3), Splicing factor 3A subunit 3, Spliceosome associated protein 61, SAP 61, SF3a60

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q12874 SF3A3

Gene Names

SF3A3, SAP61

Chain

chain:1-501

Reference Genes

BioGPS Gene:10946 SF3A3

COSMIC (genes):SF3A3 SF3A3

CTD Gene:10946 SF3A3

dbSNP Gene:10946 SF3A3

ENSEMBL:ENSG00000183431 SF3A3

HGNC:10767 SF3A3

KEGG:hsa:10946 SF3A3

Monarch:10946 SF3A3

NCBI Gene:10946 SF3A3

OMIM:605596 SF3A3

UCSC:Q12874 SF3A3

Reference Transcript

RefSeq:NM_006802.3 SF3A3

Other Identifiers

10946

11718112_at

11718113_a_at

16685544

203818_PM_s_at

203818_s_at

2407440

2407441

2407442

2407443

2407444

2407445

2407446

2407447

2407448

2407449

2407450

2407451

2407452

2407453

2407454

2407455

2407456

2407457

2407459

2407460

2407461

2407462

2407465

2407466

2407468

2407469

2407470

2407471

3395675

3395676

37379_at

3895496

3895497

3895498

3895504

3895506

3895507

3895508

3895511

4044003

4044004

4044005

4044006

4044007

4044008

4044013

7915130

A_21_P0000193

A_32_P63913

GE60076

GO:0000375

GO:0000389

GO:0000398

GO:0003676

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005684

GO:0005686

GO:0006397

GO:0008270

GO:0008380

GO:0016071

GO:0016607

GO:0043226

GO:0046872

GO:0065003

GO:0071005

GO:0071013

GO:1903241

HMNXSV003038052

ILMN_1705151

PH_hs_0004499

PH_hs_0040561

TC01002529.hg

U08815_at

g5803166_3p_a_at

Participates

as a component of

SF3A [nucleoplasm] (Homo sapiens)

Inferred To

Sf3a3 [nucleoplasm] (Mus musculus)

Sf3a3 [nucleoplasm] (Rattus norvegicus)

sf3a3 [nucleoplasm] (Danio rerio)

sf3a3 [nucleoplasm] (Dictyostelium discoideum)

sf3a3 [nucleoplasm] (Xenopus tropicalis)

prp-9 [nucleoplasm] (Caenorhabditis elegans)

SF3A3 [nucleoplasm] (Bos taurus)

SF3A3 [nucleoplasm] (Canis familiaris)

SF3A3 [nucleoplasm] (Gallus gallus)

SF3A3 [nucleoplasm] (Plasmodium falciparum)

SF3A3 [nucleoplasm] (Sus scrofa)

noi [nucleoplasm] (Drosophila melanogaster)

sap61 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_006793.1

OpenTargets

ENSG00000183431

ENSEMBL

ENSP00000362110, ENST00000373019

HPA

ENSG00000183431-SF3A3

PRO

Q12874

Pharos - Targets

Q12874

GlyGen

Q12874

PDB

7Q4P, 8QZS, 8H6E, 6Y5Q, 7Q4O, 8HK1, 6FF7, 5Z56, 6AH0, 5Z57, 8CH6, 6Y53, 8H6K, 8H6J, 8R0B, 7EVO, 7QTT, 7ABG, 7Q3L, 8H6L, 7ONB, 6AHD, 8QXD, 7VPX, 6Y50, 6QX9, 8R0A, 7ABI, 7ABH, 8R09, 8QO9, 8RM5, 2DT7, 5Z58, 8R08

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.643	5
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.643	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.556	3
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	2
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.527	2
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.527	4
UniProt:Q15274 QPRT	1	QPRT [cytosol] (R-HSA-197212)	0.527	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	2
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.508	2