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TLE2 [nucleoplasm]
Stable Identifier
R-HSA-212354
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
HES1 binds TLE (Homo sapiens)
HES1:TLE [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Repression of WNT target genes (Homo sapiens)
TLE forms non-functional complexes with AES (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
TLE:AES [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
TLE oligomerizes (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
TLE recruits HDAC1 to WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
TLE tetramers bind TCF/LEF at WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
XIAP binds TLE (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
TLE:XIAP [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
XIAP monoubiquinates TLE (Homo sapiens)
TLE:XIAP [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Homo sapiens)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE2 tetramer [nucleoplasm] (Homo sapiens)
TLE2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04725 TLE2
Gene Names
TLE2
Chain
chain:1-743
Reference Genes
BioGPS Gene:7089 TLE2
COSMIC (genes):TLE2 TLE2
CTD Gene:7089 TLE2
dbSNP Gene:7089 TLE2
ENSEMBL:ENSG00000065717 TLE2
HGNC:11838 TLE2
KEGG:hsa:7089 TLE2
Monarch:7089 TLE2
NCBI Gene:7089 TLE2
OMIM:601041 TLE2
UCSC:Q04725 TLE2
Reference Transcript
RefSeq:NM_001300846.1 TLE2
RefSeq:NM_003260.4 TLE2
RefSeq:NM_001144762.1 TLE2
RefSeq:NM_001144761.1 TLE2
Other Identifiers
11722743_a_at
11742103_a_at
11750171_a_at
16867018
204431_PM_at
204431_at
3316108
3846077
3846078
3846081
3846082
3846083
3846084
3846085
3846086
3846087
3846088
3846090
3846091
3846092
3846095
3846096
3846097
3846098
3846099
3846103
3846104
3846105
3846107
3846108
3846109
3846110
3846111
3846112
3846113
40837_PM_at
40837_at
4886034_3p_at
4886034_3p_x_at
7089
8032553
GE58189
GO:0003714
GO:0005515
GO:0005615
GO:0005634
GO:0005654
GO:0005667
GO:0005925
GO:0006355
GO:0007165
GO:0009887
GO:0016055
GO:0016604
GO:0043226
GO:0045892
GO:0060090
GO:0090090
GO:0140110
HMNXSV003041548
ILMN_1814917
M99436_at
TC19001040.hg
g4507522_3p_at
g4507522_3p_s_at
Participates
as a member of
TLE [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
as a component of
TLE2 tetramer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ub-TLE2 [nucleoplasm]
Inferred To
gro [nucleoplasm]
(Drosophila melanogaster)
TLE2 [nucleoplasm]
(Bos taurus)
TLE2 [nucleoplasm]
(Canis familiaris)
TLE2 [nucleoplasm]
(Gallus gallus)
TLE2 [nucleoplasm]
(Sus scrofa)
tle2a [nucleoplasm]
(Danio rerio)
unc-37 [nucleoplasm]
(Caenorhabditis elegans)
tle2 [nucleoplasm]
(Xenopus tropicalis)
Tle2 [nucleoplasm]
(Mus musculus)
Tle2 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENST00000262953
,
ENST00000443826
,
ENSP00000262953
,
ENSP00000392427
,
ENSG00000065717
,
ENSP00000468279
,
ENST00000426948
,
ENSP00000392869
,
ENST00000591529
OpenTargets
ENSG00000065717
GeneCards
TLE2
HPA
ENSG00000065717-TLE2
PRO
Q04725
Pharos - Targets
Q04725
GlyGen
Q04725
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04726 TLE3
2
TLE3 [nucleoplasm]
(R-HSA-3322363)
Ub-TLE3 [nucleoplasm]
(R-HSA-3322374)
0.527
3
UniProt:Q5TAB7 RIPPLY2
1
RIPPLY2 [nucleoplasm]
(R-HSA-9825566)
0.527
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.527
3
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