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p-S345-NCF1 [cytosol]
Stable Identifier
R-HSA-9626824
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S345-p47phox
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Homo sapiens)
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
p-S345-NCF1 [cytosol] (Homo sapiens)
MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Homo sapiens)
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
p-S345-NCF1 [cytosol] (Homo sapiens)
PIN1 binds p-S345-NCF1 (Homo sapiens)
PIN1:p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
p-S345-NCF1 [cytosol] (Homo sapiens)
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
p-S345-NCF1 [cytosol] (Homo sapiens)
PKC phosphorylates NCF1 (Homo sapiens)
PIN1:p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
p-S345-NCF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14598 NCF1
Gene Names
NCF1, NOXO2, SH3PXD1A
Chain
chain:1-390
Reference Genes
BioGPS Gene:653361 NCF1
COSMIC (genes):NCF1 NCF1
CTD Gene:653361 NCF1
dbSNP Gene:653361 NCF1
ENSEMBL:ENSG00000158517 NCF1
HGNC:7660 NCF1
KEGG:hsa:653361 NCF1
Monarch:653361 NCF1
NCBI Gene:653361 NCF1
OMIM:608512 NCF1
UCSC:P14598 NCF1
Reference Transcript
RefSeq:NM_000265.5 NCF1
Other Identifiers
11746013_s_at
11746014_s_at
11747444_s_at
204961_3p_s_at
204961_PM_s_at
204961_s_at
214084_3p_x_at
214084_PM_x_at
214084_x_at
3007741
3007742
3007743
3007744
3007745
3007746
3007747
3007748
3007749
3007751
3007752
3007753
3007754
3007755
3007758
3007759
3007760
3007761
3007762
3007763
3007764
3007765
3007766
3007768
3008477
3008478
3008479
3008480
3008481
3008482
3008483
3008484
3008485
3008486
3008487
3008488
3008489
3008491
3008492
3008493
3008494
3008495
3008496
3008497
3008498
3008499
3008504
3008506
3056906
3056907
3056908
3056909
3056910
3056911
3056912
3056913
3056917
3056918
3056919
3056920
3056921
3056922
3056923
3056924
3056925
3056926
3056927
3056928
3056930
3056931
3056933
3056935
40159_r_at
653361
8133314
8133518
8140227
A_32_P116203
A_33_P3211432
A_33_P3224800
A_33_P3224803
A_33_P3369393
GE57968
GO:0002376
GO:0003824
GO:0005515
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005886
GO:0006355
GO:0006612
GO:0006801
GO:0006968
GO:0008289
GO:0009055
GO:0009898
GO:0016020
GO:0016175
GO:0016176
GO:0016491
GO:0017124
GO:0030425
GO:0031410
GO:0032010
GO:0034614
GO:0035091
GO:0042554
GO:0043020
GO:0043025
GO:0043226
GO:0043325
GO:0045087
GO:0045730
GO:0045741
GO:0045893
GO:0046330
GO:0051897
GO:0060264
GO:0071276
GO:0071333
GO:0071394
GO:0098542
GO:0098772
GO:1900745
GO:1903409
HMNXSV003039349
HMNXSV003051304
HMNXSV003055897
HMNXSV003058199
Hs.1583.1.S1_3p_at
Hs.1583.1.S1_3p_s_at
Hs.1583.1.S1_3p_x_at
ILMN_1697309
ILMN_1788768
M55067_at
PH_hs_0027532
PH_hs_0035298
TC07000438.hg
TC07000459.hg
TC07001516.hg
TC07002399.hg
TC07003026.hg
g4557784_3p_a_at
g4557784_3p_s_at
g4557784_3p_x_at
Participates
as a component of
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
PIN1:p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
Other forms of this molecule
p-6S-NCF1 [cytosol]
NCF1 [cytosol]
p-6S-NCF1 [phagolysosome]
Inferred To
phospho-Ncf1 [cytosol]
(Mus musculus)
phospho-Ncf1 [cytosol]
(Rattus norvegicus)
phospho-BEM1 [cytosol]
(Saccharomyces cerevisiae)
phospho-scd2 [cytosol]
(Schizosaccharomyces pombe)
phospho-p-S345-NCF1 [cytosol]
(Gallus gallus)
phospho-ncf1 [cytosol]
(Danio rerio)
phospho-ncf1 [cytosol]
(Xenopus tropicalis)
phospho-NCF1 [cytosol]
(Bos taurus)
phospho-NCF1 [cytosol]
(Canis familiaris)
phospho-NCF1 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 345
Coordinate
345
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_000256.4
OpenTargets
ENSG00000158517
ENSEMBL
ENSP00000289473
,
ENST00000289473
HPA
ENSG00000158517-NCF1
PRO
P14598
Pharos - Targets
P14598
Orphanet
NCF1
PDB
1WLP
,
1NG2
,
1OV3
,
1KQ6
,
8WEJ
,
1K4U
,
1UEC
,
1O7K
,
1W70
,
7YXW
,
1GD5
HMDB Protein
HMDBP02126
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.682
8
UniProt:P60709 ACTB
5
ACTB [plasma membrane]
(R-HSA-196016)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [cytosol]
(R-HSA-201861)
ACTB [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
0.558
3
UniProt:P78325 ADAM8
4
ADAM8 [tertiary granule membrane]
(R-HSA-6800884)
ADAM8 [specific granule membrane]
(R-HSA-6799563)
ADAM8 [plasma membrane]
(R-HSA-708331)
ADAM8 [ficolin-1-rich granule membrane]
(R-HSA-6801017)
0.558
2
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:Q05513 PRKCZ
5
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
PRKCZ [cytosol]
(R-HSA-58218)
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
PRKCZ [cell junction]
(R-HSA-2134483)
0.556
3
UniProt:P06396 GSN
7
GSN [cytosol]
(R-HSA-350275)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
0.556
3
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.499
2
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