Reactome | TRAF3IP1 [cilium]

TRAF3IP1 [cilium]

Stable Identifier

R-HSA-5617603

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cilium

Synonyms

IFT54, IFT B, MIPT3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TDR0 TRAF3IP1

Gene Names

TRAF3IP1, IFT54, MIPT3

Chain

chain:1-691

Reference Genes

BioGPS Gene:26146 TRAF3IP1

COSMIC (genes):TRAF3IP1 TRAF3IP1

CTD Gene:26146 TRAF3IP1

dbSNP Gene:26146 TRAF3IP1

ENSEMBL:ENSG00000204104 TRAF3IP1

ENSEMBL:ENSG00000204104.12 TRAF3IP1

HGNC:17861 TRAF3IP1

KEGG Gene (Homo sapiens):26146 TRAF3IP1

Monarch:26146 TRAF3IP1

NCBI Gene:26146 TRAF3IP1

OMIM:607380 TRAF3IP1

UCSC:Q8TDR0 TRAF3IP1

Reference Transcript

Other Identifiers

11731094_a_at

11731095_x_at

16893099

214458_PM_at

214458_at

238494_PM_at

238494_at

2534811

2534812

2534815

2534816

2534818

2534820

2534822

2534823

2534827

2534832

2534835

2534836

2534838

2534839

2534840

2534849

2534850

2534851

2534852

26146

40216_at

53119_at

8049635

A_23_P5359

A_32_P170003

GE82028

GE841904

GO:0001738

GO:0001822

GO:0001933

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0005929

GO:0005930

GO:0007010

GO:0007018

GO:0008017

GO:0008092

GO:0030030

GO:0030992

GO:0031333

GO:0032480

GO:0035720

GO:0035869

GO:0036064

GO:0036211

GO:0042073

GO:0042995

GO:0043226

GO:0044782

GO:0048856

GO:0050687

GO:0060271

GO:0065003

GO:0070507

GO:0097542

GO:0097546

GO:0098542

HMNXSV003031228

Hs.152701.0.S1_3p_at

Hs.43086.0.A1_3p_at

ILMN_1806728

ILMN_2067032

PH_hs_0035420

TC02001453.hg

Participates

as an input of

Assembly of IFT B complex (Homo sapiens)

as a component of

IFT B* [cilium] (Homo sapiens)

Other forms of this molecule

TRAF3IP1 [ciliary tip]

Inferred To

Traf3ip1 [cilium] (Mus musculus)

Traf3ip1 [cilium] (Rattus norvegicus)

dyf-11 [cilium] (Caenorhabditis elegans)

TRAF3IP1 [cilium] (Bos taurus)

TRAF3IP1 [cilium] (Canis familiaris)

TRAF3IP1 [cilium] (Gallus gallus)

TRAF3IP1 [cilium] (Sus scrofa)

traf3ip1 [cilium] (Danio rerio)

traf3ip1 [cilium] (Xenopus tropicalis)

Cross References

RefSeq

NP_056465.2, NP_001132962.1

OpenTargets

ENSG00000204104

GeneCards

Q8TDR0

HPA

ENSG00000204104-TRAF3IP1

Ensembl

ENSP00000362424, ENST00000373327, ENSP00000375851, ENST00000391993, ENSG00000204104

PRO

Q8TDR0

Pharos - Targets

Q8TDR0

Orphanet

23492

PDB

2EQO

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRI5 DISC1			0.736	9
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.664	5
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.639	8
UniProt:Q9UG01 IFT172	2	IFT172 [ciliary tip] (R-HSA-5625353) IFT172 [cilium] (R-HSA-5610383)	0.592	4
UniProt:Q13099 IFT88	8	IFT88 [ciliary tip] (R-HSA-5625371) PolyUb-Misfolded IFT88 [late endosome lumen] (R-HSA-9660031) IFT88 [cilium] (R-HSA-5610385) PolyUb-Misfolded IFT88 [lysosomal lumen] (R-HSA-9660026) PolyUb-Misfolded IFT88 [cytosol] (R-HSA-9641125) Ub-Misfolded IFT88 [cytosol] (R-HSA-9641114) Misfolded IFT88 [cytosol] (R-HSA-9640115) Misfolded IFT88 [cilium] (R-HSA-9640106)	0.592	4
UniProt:Q9P2H3 IFT80	2	IFT80 [cilium] (R-HSA-5617613) IFT80 [ciliary tip] (R-HSA-5625367)	0.508	3
UniProt:Q9NWB7 IFT57	2	IFT57 [cilium] (R-HSA-5610389) IFT57 [ciliary tip] (R-HSA-5625363)	0.508	2
UniProt:Q96LB3 IFT74	2	IFT74 [cilium] (R-HSA-5617616) IFT74 [ciliary tip] (R-HSA-5625364)	0.508	2
UniProt:P78552 IL13RA1	2	IL13RA1 [plasma membrane] (R-HSA-449671) p-Y-IL13RA1 [plasma membrane] (R-HSA-6786750)	0.508	3
UniProt:Q8IY31 IFT20	3	IFT20 [cilium] (R-HSA-5617624) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [ciliary tip] (R-HSA-5625355)	0.502	2

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