Reactome | WNK1 [cytosol]

WNK1 [cytosol]

Stable Identifier

R-HSA-2672391

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase WNK1 ecNumber2.7.11.1/ecNumber, WNK1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9H4A3 WNK1

Gene Names

WNK1, HSN2, KDP, KIAA0344, PRKWNK1

Chain

chain:1-2382

Reference Genes

BioGPS Gene:65125 WNK1

COSMIC (genes):WNK1 WNK1

CTD Gene:65125 WNK1

dbSNP Gene:65125 WNK1

ENSEMBL:ENSG00000060237 WNK1

HGNC:14540 WNK1

KEGG Gene (Homo sapiens):65125 WNK1

Monarch:65125 WNK1

NCBI Gene:65125 WNK1

OMIM:605232 WNK1

UCSC:Q9H4A3 WNK1

Reference Transcript

Other Identifiers

0000630091

11743278_at

11743279_x_at

11743280_a_at

11743281_a_at

16746591

211992_at

211993_at

211994_at

32185_at

3400052

3400053

3400054

3400055

3400056

3400079

3400080

3400083

3400090

3400100

3400101

3400103

3400105

3400106

3400115

3400122

3400123

3400124

3400125

3400126

3400127

3400129

3400130

3400131

3400135

3400136

3400137

3400138

3400139

3400140

3400142

3400143

3400144

3400145

3400146

3400147

3400148

3400149

3400150

3400153

3400154

3400156

3400157

3400158

3400162

3400163

3400164

3400166

3400177

3400178

3400180

3400181

3400182

3400183

3400184

3400185

3400186

3400187

3400188

3400189

3400388

3400390

54999_at

65125

7952953

86302_at

A_14_P102716

A_14_P128585

A_23_P250701

A_23_P84587

A_24_P769359

GE795264

GE82462

GE85853

GO:0000166

GO:0002028

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0004860

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006464

GO:0006468

GO:0006469

GO:0006810

GO:0006811

GO:0007155

GO:0007165

GO:0007267

GO:0008150

GO:0009790

GO:0010766

GO:0010820

GO:0010923

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0018107

GO:0019869

GO:0019870

GO:0019899

GO:0019901

GO:0019902

GO:0023016

GO:0030154

GO:0030234

GO:0030295

GO:0032147

GO:0032414

GO:0033633

GO:0034115

GO:0034260

GO:0035556

GO:0038116

GO:0040011

GO:0042592

GO:0043167

GO:0048666

GO:0048856

GO:0048870

GO:0050794

GO:0050801

GO:0050852

GO:0055085

GO:0090263

GO:0097022

GO:1903038

GO:1903288

GO:1904062

GO:1990869

GO:2000651

Hs.184592.0.S1_3p_at

Hs.184592.0.S3_3p_at

Hs.184592.0.S4_3p_at

Hs.184592.0.S4_3p_x_at

ILMN_1753165

ILMN_1876924

PH_hs_0032428

TC12000010.hg

TC12002169.hg

Participant Of

hasMember

WNKs [cytosol]

Inferred To

Wnk1 [cytosol] (Mus musculus)

Wnk1 [cytosol] (Rattus norvegicus)

wnk-1 [cytosol] (Caenorhabditis elegans)

WNK1 [cytosol] (Canis familiaris)

WNK1 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_061852.3, NP_055638.2, NP_001171914.1, NP_998820.3, XP_016875326.1, XP_016875327.1

OpenTargets

ENSG00000060237

GeneCards

Q9H4A3

HPA

ENSG00000060237-WNK1

ZINC target

Q9H4A3

Ensembl

ENSP00000313059, ENST00000315939, ENSG00000060237

PRO

Q9H4A3

Orphanet

15725

PDB

5WE8, 4PWN, 6FBK, 5WDY, 5TF9

HMDB Protein

HMDBP08231

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.544	2
UniProt:Q15149 PLEC	3	PLEC(1-2395) [cytosol] (R-HSA-350638) PLEC(2396-4684) [cytosol] (R-HSA-350618) PLEC [cytosol] (R-HSA-201575)	0.534	2
UniProt:P11142 HSPA8	10	HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.462	3

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