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WNK1 [cytosol]
Stable Identifier
R-HSA-2672391
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine/threonine-protein kinase WNK1 ecNumber2.7.11.1/ecNumber, WNK1_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Stimuli-sensing channels (Homo sapiens)
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Homo sapiens)
WNKs [cytosol] (Homo sapiens)
WNK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H4A3 WNK1
Gene Names
WNK1, HSN2, KDP, KIAA0344, PRKWNK1
Chain
chain:1-2382
Reference Genes
BioGPS Gene:65125 WNK1
COSMIC (genes):WNK1 WNK1
CTD Gene:65125 WNK1
dbSNP Gene:65125 WNK1
ENSEMBL:ENSG00000060237 WNK1
HGNC:14540 WNK1
KEGG Gene (Homo sapiens):65125 WNK1
Monarch:65125 WNK1
NCBI Gene:65125 WNK1
OMIM:605232 WNK1
UCSC:Q9H4A3 WNK1
Reference Transcript
RefSeq:NM_014823.2 WNK1
RefSeq:NM_001184985.1 WNK1
RefSeq:NM_213655.4 WNK1
RefSeq:NM_018979.3 WNK1
RefSeq:XM_017019838.1 WNK1
RefSeq:XM_017019837.1 WNK1
Other Identifiers
0000630091
11737175_at
11743278_at
11743279_x_at
11743280_a_at
11743281_a_at
16746591
211992_at
211993_at
211994_at
32185_at
3400052
3400053
3400054
3400055
3400056
3400079
3400080
3400083
3400090
3400100
3400101
3400103
3400105
3400106
3400108
3400109
3400110
3400115
3400122
3400123
3400124
3400125
3400126
3400127
3400129
3400130
3400131
3400135
3400136
3400137
3400138
3400139
3400140
3400142
3400143
3400144
3400145
3400146
3400147
3400148
3400149
3400150
3400153
3400154
3400156
3400157
3400158
3400162
3400163
3400164
3400166
3400168
3400177
3400178
3400180
3400181
3400182
3400183
3400184
3400185
3400186
3400187
3400188
3400189
3400386
3400388
3400390
54999_at
65125
73353_at
7952953
7952986
86302_at
A_14_P102716
A_14_P128585
A_23_P250701
A_23_P84587
A_24_P769359
A_33_P3510335
GE795264
GE82462
GE85853
GO:0000166
GO:0000287
GO:0002028
GO:0002376
GO:0003013
GO:0003084
GO:0003674
GO:0004672
GO:0004674
GO:0004860
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0006469
GO:0006810
GO:0006811
GO:0007155
GO:0007165
GO:0007267
GO:0008150
GO:0009790
GO:0010766
GO:0010820
GO:0010923
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0018107
GO:0019869
GO:0019870
GO:0019899
GO:0019901
GO:0019902
GO:0030154
GO:0030234
GO:0030291
GO:0030295
GO:0032147
GO:0033633
GO:0033673
GO:0034115
GO:0034260
GO:0035556
GO:0038116
GO:0040011
GO:0042592
GO:0043167
GO:0046777
GO:0048666
GO:0048856
GO:0048870
GO:0050794
GO:0050801
GO:0050852
GO:0055085
GO:0071277
GO:0090188
GO:0090263
GO:0097022
GO:0106310
GO:0106311
GO:1903038
GO:1903288
GO:1904062
GO:1990869
GO:2000651
HMNXSV003013350
HMNXSV003020758
Hs.184592.0.S1_3p_at
Hs.184592.0.S3_3p_at
Hs.184592.0.S4_3p_at
Hs.184592.0.S4_3p_x_at
ILMN_1753165
ILMN_1788711
ILMN_1876924
PH_hs_0032428
PH_hs_0032851
TC12000010.hg
TC12000012.hg
TC12002169.hg
Participates
as a member of
WNKs [cytosol] (Homo sapiens)
Inferred To
Wnk1 [cytosol]
(Mus musculus)
Wnk1 [cytosol]
(Rattus norvegicus)
wnk-1 [cytosol]
(Caenorhabditis elegans)
WNK1 [cytosol]
(Canis familiaris)
WNK1 [cytosol]
(Gallus gallus)
WNK1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_998820.3
,
XP_016875326.1
,
NP_001171914.1
,
NP_055638.2
,
NP_061852.3
,
XP_016875327.1
Guide to Pharmacology - Targets
2280
OpenTargets
ENSG00000060237
ZINC target
Q9H4A3
PRO
Q9H4A3
GlyGen
Q9H4A3
PDB
6FBK
,
5TF9
,
4PWN
,
5WDY
,
5WE8
IntEnz
2.7.11.1
HPA
ENSG00000060237-WNK1
GeneCards
Q9H4A3
Ensembl
ENST00000340908
,
ENST00000537687
,
ENSP00000313059
,
ENSP00000341292
,
ENSP00000444465
,
ENSP00000433548
,
ENST00000315939
,
ENST00000530271
,
ENSG00000060237
Pharos - Targets
Q9H4A3
Orphanet
15725
HMDB Protein
HMDBP08231
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.544
2
UniProt:Q15149 PLEC
3
PLEC(2396-4684) [cytosol]
(R-HSA-350618)
PLEC(1-2395) [cytosol]
(R-HSA-350638)
PLEC [cytosol]
(R-HSA-201575)
0.534
2
UniProt:Q2M2I8 AAK1
1
AAK1 [cytosol]
(R-HSA-8854795)
0.508
2
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