Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
WNK1 [cytosol]
Stable Identifier
R-HSA-2672391
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Serine/threonine-protein kinase WNK1 ecNumber2.7.11.1/ecNumber, WNK1_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Stimuli-sensing channels (Homo sapiens)
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Homo sapiens)
WNKs [cytosol] (Homo sapiens)
WNK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H4A3 WNK1
Gene Names
WNK1, HSN2, KDP, KIAA0344, PRKWNK1
Chain
chain:1-2382
Reference Genes
BioGPS Gene:65125 WNK1
COSMIC (genes):WNK1 WNK1
CTD Gene:65125 WNK1
dbSNP Gene:65125 WNK1
ENSEMBL:ENSG00000060237 WNK1
HGNC:14540 WNK1
KEGG:hsa:65125 WNK1
Monarch:65125 WNK1
NCBI Gene:65125 WNK1
OMIM:605232 WNK1
UCSC:Q9H4A3 WNK1
Reference Transcript
RefSeq:XM_017019837.1 WNK1
RefSeq:NM_213655.4 WNK1
RefSeq:XM_017019838.1 WNK1
RefSeq:NM_018979.3 WNK1
RefSeq:NM_014823.2 WNK1
RefSeq:NM_001184985.1 WNK1
Other Identifiers
11737175_at
11743278_at
11743279_x_at
11743280_a_at
11743281_a_at
1555068_PM_at
1555068_at
16746591
202940_PM_at
202940_at
211992_PM_at
211992_at
211993_PM_at
211993_at
211994_PM_at
211994_at
32185_at
3400052
3400053
3400054
3400055
3400056
3400079
3400080
3400083
3400084
3400085
3400088
3400089
3400090
3400098
3400100
3400101
3400103
3400104
3400105
3400106
3400108
3400109
3400110
3400113
3400114
3400115
3400120
3400121
3400122
3400123
3400124
3400125
3400126
3400127
3400129
3400130
3400131
3400132
3400133
3400134
3400135
3400136
3400137
3400138
3400139
3400140
3400141
3400142
3400143
3400144
3400145
3400146
3400147
3400148
3400149
3400150
3400153
3400154
3400156
3400157
3400158
3400162
3400163
3400164
3400166
3400167
3400168
3400169
3400170
3400176
3400177
3400178
3400179
3400180
3400181
3400182
3400183
3400184
3400185
3400186
3400187
3400188
3400189
3400386
3400388
3400390
39313_PM_at
39313_at
54999_at
58750_at
65125
73353_at
7952953
7952986
81271_at
86302_at
A_14_P102716
A_14_P105859
A_14_P128585
A_23_P250701
A_23_P84587
A_24_P51127
A_24_P769359
A_24_P943429
A_33_P3510335
GE795264
GE82462
GE85853
GO:0002028
GO:0002376
GO:0003084
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0006355
GO:0006468
GO:0006811
GO:0006884
GO:0007165
GO:0007507
GO:0008217
GO:0010507
GO:0010766
GO:0010793
GO:0010820
GO:0016020
GO:0016301
GO:0016740
GO:0018105
GO:0018107
GO:0019901
GO:0019902
GO:0030295
GO:0030644
GO:0031397
GO:0032991
GO:0033633
GO:0034115
GO:0034260
GO:0035556
GO:0035725
GO:0038116
GO:0042592
GO:0043226
GO:0043232
GO:0045050
GO:0045766
GO:0048666
GO:0048856
GO:0048870
GO:0050852
GO:0055075
GO:0055080
GO:0055085
GO:0060090
GO:0071474
GO:0072686
GO:0090188
GO:0090263
GO:0097022
GO:0098772
GO:0106310
GO:0140096
GO:0140693
GO:0140694
GO:1902305
GO:1903038
GO:1903077
GO:1903490
GO:1904062
GO:1904595
GO:1990869
HMNXSV003013350
HMNXSV003020758
Hs.184592.0.S1_3p_at
Hs.184592.0.S3_3p_at
Hs.184592.0.S4_3p_at
Hs.184592.0.S4_3p_x_at
Hs2.432900.2.S1_3p_at
ILMN_1753165
ILMN_1788711
ILMN_1876924
PH_hs_0032428
PH_hs_0032851
TC12000010.hg
TC12000012.hg
TC12002169.hg
g7662065_3p_s_at
Participates
as a member of
WNKs [cytosol] (Homo sapiens)
Cross References
Guide to Pharmacology - Targets
2280
OpenTargets
ENSG00000060237
ENSEMBL
ENST00000530271
,
ENST00000537687
,
ENSP00000341292
,
ENSP00000444465
,
ENSP00000433548
,
ENSP00000313059
,
ENST00000315939
,
ENSP00000502415
,
ENST00000675631
,
ENST00000340908
HPA
ENSG00000060237-WNK1
ZINC - Substances
WNK1_HUMAN
ZINC target
Q9H4A3
PRO
Q9H4A3
Pharos - Targets
Q9H4A3
Orphanet
WNK1
GlyGen
Q9H4A3
PDB
4PWN
,
5TF9
,
5WDY
,
6FBK
,
5WE8
HMDB Protein
HMDBP08231
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.707
7
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.706
5
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.64
3
UniProt:P11142 HSPA8
10
HSPA8 [cytosol]
(R-HSA-264476)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
0.569
5
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.544
2
UniProt:Q15149 PLEC
3
PLEC(2396-4684) [cytosol]
(R-HSA-350618)
PLEC(1-2395) [cytosol]
(R-HSA-350638)
PLEC [cytosol]
(R-HSA-201575)
0.534
2
UniProt:Q2M2I8 AAK1
1
AAK1 [cytosol]
(R-HSA-8854795)
0.508
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
4
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text