Reactome | BAG4 [cytosol]

BAG4 [cytosol]

Stable Identifier

R-HSA-5212670

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SODD, BAG family molecular chaperone regulator 4

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to heat stress (Homo sapiens)
    - Regulation of HSF1-mediated heat shock response (Homo sapiens)
      - HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
        
        HSP70 NEFs [cytosol] (Homo sapiens)
        
        BAG1-5 [cytosol] (Homo sapiens)
        
        BAG4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95429 BAG4

Gene Names

BAG4, SODD

Chain

chain:1-457

Reference Genes

COSMIC (genes):BAG4 BAG4

ENSEMBL:ENSG00000156735 BAG4

HGNC:940 BAG4

UCSC:O95429 BAG4

Other Identifiers

11743422_a_at

11747805_a_at

11759495_at

17068003

219624_PM_at

219624_at

222909_PM_s_at

222909_s_at

228189_PM_at

228189_at

2518866

3094495

3094496

3094502

3094503

3094504

3094505

3094506

3094507

3094508

3094509

47063_at

48414_at

55982_at

8145914

9530

A_14_P113907

A_23_P146217

A_24_P930926

GE61962

GE87904

GO:0000774

GO:0003723

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006457

GO:0010763

GO:0016020

GO:0030838

GO:0031625

GO:0033138

GO:0043066

GO:0043226

GO:0044877

GO:0045785

GO:0050821

GO:0051087

GO:0051496

GO:0051897

GO:0071356

GO:0071364

GO:0072659

GO:0090367

GO:0097178

GO:0098772

GO:1903215

HMNXSV003046383

Hs.7859.0.A1_3p_at

ILMN_1727996

ILMN_2221014

PH_hs_0011517

TC08000287.hg

g4160013_3p_a_at

g6631074_3p_at

Participates

as a member of

BAG1-5 [cytosol] (Homo sapiens)

as an output of

as a component of

TNFRSF1A:BAG4 [plasma membrane] (Homo sapiens)

Other forms of this molecule

BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane]

BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane]

Inferred To

Homologues of BAG4 [cytosol] (Schizosaccharomyces pombe)

bag102 [cytosol] (Schizosaccharomyces pombe)

Bag4 [cytosol] (Mus musculus)

Bag4 [cytosol] (Rattus norvegicus)

BAG4 [cytosol] (Bos taurus)

BAG4 [cytosol] (Sus scrofa)

bag101 [cytosol] (Schizosaccharomyces pombe)

Cross References

OpenTargets

ENSG00000156735

ENSEMBL

ENST00000287322, ENST00000432471, ENSP00000393298, ENSP00000287322

HPA

ENSG00000156735-BAG4

PRO

O95429

Pharos - Targets

O95429

GlyGen

O95429

Interactors (101)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.787	6
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.703	5
UniProt:Q9P0N9 TBC1D7	1	TBC1D7 [cytosol] (R-HSA-8854154)	0.696	5
UniProt:Q8IZD4 DCP1B	1	DCP1B [cytosol] (R-HSA-429834)	0.669	3
UniProt:P34931 HSPA1L	2	HSPA1L [nucleoplasm] (R-HSA-5082367) HSPA1L [cytosol] (R-HSA-3371410)	0.666	4
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.666	6
UniProt:Q5JPI3-2 C3ORF38			0.666	4
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.643	3
UniProt:Q99615 DNAJC7	2	DNAJC7 [nucleoplasm] (R-HSA-5255408) DNAJC7 [cytosol] (R-HSA-5252099)	0.623	3
UniProt:hspa1a_hspa1b_human-1 EBI-11820565			0.601	9
UniProt:Q9BTL3 RAMAC			0.601	6
UniProt:P02794 FTH1	5	FTH1 [cytosol] (R-HSA-434212) FTH1 [tertiary granule lumen] (R-HSA-6801508) FTH1 [extracellular region] (R-HSA-2187212) FTH1 [ficolin-1-rich granule lumen] (R-HSA-6801531) FTH1 [endocytic vesicle lumen] (R-HSA-2299670)	0.601	4
UniProt:Q03933 HSF2			0.564	2
UniProt:Q14990 ODFP1			0.556	3
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.556	3
UniProt:P28074 PSMB5	4	PSMB5 [cytosol] (R-HSA-68753) PSMB5 [nucleoplasm] (R-HSA-174344) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5(1-59) [cytosol] (R-HSA-9908134)	0.556	5
UniProt:Q9BYR2 KRTAP4-5	1	KRTAP4-5 [cytosol] (R-HSA-6809950)	0.556	3
UniProt:Q9BYR3 KRTAP4-4	1	KRTAP4-4 [cytosol] (R-HSA-6809966)	0.556	3
UniProt:O75865-2 TRAPPC6A			0.556	3
UniProt:O95988 TCL1B			0.556	3
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
UniProt:Q96MP8-2 KCTD7			0.556	3
UniProt:P17066 HSPA6	5	HSPA6 [cytosol] (R-HSA-3371521) HSPA6 [nucleoplasm] (R-HSA-5252088) HSPA6 [ficolin-1-rich granule lumen] (R-HSA-6801512) HSPA6 [extracellular region] (R-HSA-6806500) HSPA6 [secretory granule lumen] (R-HSA-6801472)	0.556	3
UniProt:Q9GZM7 TINAL			0.556	3
UniProt:Q9UBV8 PEF1			0.556	5
UniProt:Q7Z5V6-2 SAXO4			0.556	6
UniProt:O75340 PDCD6			0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:Q8IUQ4-2 SIAH1			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q8IXY8 PPIL6	1	PPIL6 [nucleoplasm] (R-HSA-8952111)	0.556	3
UniProt:Q99816 TSG101	1	TSG101 [endosome membrane] (R-HSA-2980549)	0.556	3
UniProt:Q8IXM7 CMA1C			0.556	3
UniProt:Q8WU58 F222B			0.556	3
UniProt:P14678-2 SNRPB			0.556	5
UniProt:Q14847-2 LASP1			0.556	3
UniProt:Q86VE0 MYPOP			0.556	3
IntAct:EBI-22432104 CCSB ORF ID			0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:P0DTC4 E	9	Ub-3xPalmC-E [virion membrane] (R-COV-9698416) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754)	0.556	3
UniProt:Q8IYX7 SAXO1			0.556	3
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.556	3
UniProt:Q9Y6H3 ATP23			0.556	3
UniProt:Q86Y13 DZIP3	1	DZIP3 [cytosol] (R-HSA-976002)	0.556	3
UniProt:O75177-5 SS18L1			0.556	3
IntAct:EBI-16435576 CCSB ORF ID			0.556	3
UniProt:P06241-3 FYN			0.556	3
UniProt:Q9UPT9-2 USP22			0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	5
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	5
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.556	3
UniProt:Q9BQ66 KR412			0.556	3
UniProt:Q96EJ4 Q96EJ4			0.556	3
UniProt:Q8TDC0 MYOZ3			0.556	3
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.556	3
UniProt:Q7Z4N8 P4HA3	1	P4HA3 [endoplasmic reticulum lumen] (R-HSA-2980915)	0.556	3
UniProt:Q7Z6R9 TFAP2D	1	TFAP2D [nucleoplasm] (R-HSA-5626817)	0.556	5
UniProt:Q96D03 DDT4L			0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:Q96K62 ZBT45			0.556	3
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
UniProt:Q12805 EFEMP1	1	EFEMP1 [extracellular region] (R-HSA-2161393)	0.556	3
UniProt:A8MW99 MEI4			0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	5
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:P42575 CASP2	3	CASP2(170-325) [cytosol] (R-HSA-2976746) CASP2(348-452) [cytosol] (R-HSA-2976745) CASP2(2-452) [cytosol] (R-HSA-622412)	0.556	3
UniProt:Q13227 GPS2	1	GPS2 [nucleoplasm] (R-HSA-351642)	0.556	3
UniProt:Q7L5A3 ATOSB			0.556	5
UniProt:Q96A10 Q96A10			0.556	3
UniProt:O95872 GPAN1			0.556	3
UniProt:A8KA13 A8KA13			0.556	3
UniProt:P33176 KIF5B	3	KIF5B [cytosol] (R-HSA-265181) KIF5B(2-575)-p-7Y-ALK(1063-1620) fusion [cytosol] (R-HSA-9711937) KIF5B(2-575)-ALK(1063-1620) fusion [cytosol] (R-HSA-9711964)	0.556	3
UniProt:O43439-4 CBFA2T2			0.556	3
UniProt:Q9H9P5-5 UNKL			0.556	3
UniProt:Q9NP73-4 ALG13			0.556	3
UniProt:Q9UPU9-3 SAMD4A			0.556	3
UniProt:Q53H96 PYCRL	1	PYCR3 [cytosol] (R-HSA-6783934)	0.556	3
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.556	3
UniProt:O00154-4 ACOT7			0.556	3
UniProt:Q8TEC5 SH3R2			0.556	3
UniProt:Q9NP98 MYOZ1			0.556	3
UniProt:P53990-3 IST1			0.556	3
UniProt:O15062 ZBTB5			0.556	3
UniProt:Q01196-8 RUNX1			0.556	3
UniProt:Q96M29 TEKT5			0.556	3
UniProt:Q6DHY5 TBC3G			0.556	3
UniProt:Q3LI77 KRTAP13-4	1	KRTAP13-4 [cytosol] (R-HSA-6810302)	0.556	3
UniProt:Q9NZV7 ZIM2	1	ZIM2 [nucleoplasm] (R-HSA-974996)	0.556	3
UniProt:P0DTD1-PRO_0000449622 REP			0.556	3
UniProt:Q9H7S9 ZNF703	1	ZNF703 [nucleoplasm] (R-HSA-2454149)	0.527	2
UniProt:O75165 DNAJC13	3	DNAJC13 [azurophil granule membrane] (R-HSA-6799140) DNAJC13 [plasma membrane] (R-HSA-6806255) DNAJC13 [secretory granule membrane] (R-HSA-6800951)	0.527	2
UniProt:Q2TAL8 QRIC1			0.527	2
UniProt:Q96CP2 FWCH2			0.527	2
UniProt:Q14249 NUCG			0.527	2
UniProt:Q5H9F3 BCORL			0.527	2
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.527	2
UniProt:P35268 RPL22	1	RPL22 [cytosol] (R-HSA-72428)	0.488	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	2

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