Reactome | TRIM33 [nucleoplasm]

TRIM33 [nucleoplasm]

Stable Identifier

R-HSA-870522

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase TRIM33, Ectodermin, TIF1-gamma

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UPN9 TRIM33

Gene Names

TRIM33, KIAA1113, RFG7, TIF1G

Chain

chain:1-1127

Reference Genes

BioGPS Gene:51592 TRIM33

COSMIC (genes):TRIM33 TRIM33

CTD Gene:51592 TRIM33

dbSNP Gene:51592 TRIM33

ENSEMBL:ENSG00000197323 TRIM33

ENSEMBL_homo_sapiens_GENE:ENSG00000197323.12 TRIM33

HGNC:16290 TRIM33

KEGG Gene (Homo sapiens):51592 TRIM33

Monarch:51592 TRIM33

NCBI Gene:51592 TRIM33

OMIM:605769 TRIM33

UCSC:Q9UPN9 TRIM33

Reference Transcript

Other Identifiers

11720259_a_at

11720260_a_at

11720261_a_at

16691177

210266_PM_s_at

210266_s_at

212435_PM_at

212435_at

212436_PM_at

212436_at

2429068

2429070

2429071

2429072

2429073

2429074

2429075

2429077

2429079

2429082

2429085

2429086

2429090

2429091

2429093

2429094

2429095

2429098

2429101

2429112

2429114

2429115

2429116

2429117

2429118

2429120

2429121

2429123

2429125

2429131

2429132

2429134

2429140

2429141

2429142

2429143

2429144

2429145

32635_at

35187_at

48845_at

51183_at

51592

7918725

A_23_P23526

A_24_P34344

A_33_P3257367

GE54829

GE56365

GE820633

GO:0000122

GO:0003677

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0008270

GO:0016567

GO:0016740

GO:0017015

GO:0023052

GO:0030514

GO:0036211

GO:0043226

GO:0045892

GO:0046872

GO:0070410

GO:0070412

GO:0140096

HMNXSV003040112

Hs.26837.0.S1_3p_at

Hs.26837.0.S2_3p_at

ILMN_1682316

ILMN_1738672

ILMN_2351930

PH_hs_0002373

PH_hs_0023549

TC01003011.hg

g12407442_3p_s_at

Participates

as a component of

as an input of

TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Homo sapiens)

as an output of

TRIM33 monoubiquitinates SMAD4 (Homo sapiens)

Inferred To

Trim33 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of TRIM33 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of TRIM33 [nucleoplasm] (Drosophila melanogaster)

TRIM33 [nucleoplasm] (Bos taurus)

TRIM33 [nucleoplasm] (Canis familiaris)

TRIM33 [nucleoplasm] (Danio rerio)

TRIM33 [nucleoplasm] (Gallus gallus)

TRIM33 [nucleoplasm] (Mus musculus)

TRIM33 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_056990.3, NP_148980.2

Guide to Pharmacology - Targets

2254

OpenTargets

ENSG00000197323

ZINC target

Q9UPN9

PRO

Q9UPN9

PDB

3U5M, 8BD8, 8BD9, 3U5N, 7ZDD, 3U5O, 5MR8, 3U5P, 8BDY

IntEnz

2.3.2.27

HPA

ENSG00000197323-TRIM33

GeneCards

Q9UPN9

Ensembl

ENST00000369543, ENST00000358465, ENSG00000197323, ENSP00000351250, ENSP00000358556

Pharos - Targets

Q9UPN9

Orphanet

15662

HMDB Protein

HMDBP09287

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15164 TRIM24	4	TRIM24(1-626)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614442) TRIM24(1-626)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839012) TRIM24(1-510)-BRAF(381-766) fusion [cytosol] (R-HSA-6802477) TRIM24(1-510)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802555)	0.794	6
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.748	6
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 D300V [cytosol] (R-HSA-3315067) SMAD2 S464* [cytosol] (R-HSA-3304362) SMAD2 W422* [cytosol] (R-HSA-9668736) SMAD2 S308* [cytosol] (R-HSA-9668732) SMAD2 R427* [cytosol] (R-HSA-9668733) SMAD2 W448* [cytosol] (R-HSA-9668734) SMAD2 S464L [cytosol] (R-HSA-3304383) SMAD2 C463* [cytosol] (R-HSA-9668735) SMAD2 R321* [cytosol] (R-HSA-9668728) SMAD2 S296* [cytosol] (R-HSA-9668729) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 L315* [cytosol] (R-HSA-9668725)	0.662	6
UniProt:Q13263 TRIM28	3	SUMO1-K554,575,676,750,779,804-TRIM28 [nucleoplasm] (R-HSA-3782600) TRIM28 [nucleoplasm] (R-HSA-974998) SUMO2-K554,K575,K676,K750,K779,K804-TRIM28 [nucleoplasm] (R-HSA-9842867)	0.643	4
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.597	4
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.527	3
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.527	2
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.462	3
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.462	3
IntAct:EBI-2902122 GATA1			0.462	2
IntAct:EBI-2902124 GATA2			0.462	2
UniProt:P17542 TAL1	1	TAL1 [nucleoplasm] (R-HSA-8956511)	0.462	3

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