Reactome | SF3A1 [nucleoplasm]

SF3A1 [nucleoplasm]

Stable Identifier

R-HSA-71962

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SAP 114 (Splicing factor 3A subunit 1), Splicing factor 3 subunit 1, Spliceosome associated protein 114, SAP 114, SF3a120

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15459 SF3A1

Gene Names

SF3A1, SAP114

Chain

initiator methionine:, chain:2-793

Reference Genes

BioGPS Gene:10291 SF3A1

COSMIC (genes):SF3A1 SF3A1

CTD Gene:10291 SF3A1

dbSNP Gene:10291 SF3A1

ENSEMBL:ENSG00000099995 SF3A1

HGNC:10765 SF3A1

KEGG:hsa:10291 SF3A1

Monarch:10291 SF3A1

NCBI Gene:10291 SF3A1

OMIM:605595 SF3A1

UCSC:Q15459 SF3A1

Reference Transcript

RefSeq:NM_005877.5 SF3A1

Other Identifiers

10291

11721072_a_at

11721073_a_at

11750638_a_at

16933818

201356_PM_at

201356_at

201357_PM_s_at

201357_s_at

216457_PM_s_at

216457_s_at

227516_PM_at

227516_at

34733_at

3957261

3957262

3957263

3957264

3957266

3957267

3957268

3957269

3957270

3957271

3957272

3957273

3957274

3957275

3957276

3957277

3957278

3957279

3957280

3957281

3957283

3957284

3957285

3957286

3957287

3957289

3957290

3957291

3957292

3957293

78615_at

8075343

91167_s_at

91508_at

A_23_P104676

A_23_P211436

A_24_P250614

A_24_P374154

A_33_P3210059

GE60099

GO:0000389

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005684

GO:0005686

GO:0006396

GO:0006397

GO:0008380

GO:0016071

GO:0016607

GO:0043226

GO:0045292

GO:0065003

GO:0071004

GO:0071005

GO:0071013

GO:1903241

HMNXSV003017445

Hs.288883.0.A2_3p_a_at

Hs.288883.0.A2_3p_at

Hs.288883.1.S1_3p_at

Hs.288883.2.A1_3p_a_at

ILMN_1655809

ILMN_1697286

PH_hs_0034193

TC22000650.hg

X85237_at

g5032086_3p_a_at

Participates

as a component of

SF3A [nucleoplasm] (Homo sapiens)

Inferred To

SF3A1 [nucleoplasm] (Bos taurus)

SF3A1 [nucleoplasm] (Canis familiaris)

SF3A1 [nucleoplasm] (Gallus gallus)

SF3A1 [nucleoplasm] (Plasmodium falciparum)

SF3A1 [nucleoplasm] (Sus scrofa)

Ghost homologue of SF3A1 [nucleoplasm] (Xenopus tropicalis)

sf3a1 [nucleoplasm] (Danio rerio)

sf3a1 [nucleoplasm] (Dictyostelium discoideum)

Sf3a1 [nucleoplasm] (Drosophila melanogaster)

Sf3a1 [nucleoplasm] (Mus musculus)

Sf3a1 [nucleoplasm] (Rattus norvegicus)

sap114 [nucleoplasm] (Schizosaccharomyces pombe)

prp-21 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_005868.1

OpenTargets

ENSG00000099995

ENSEMBL

ENST00000215793, ENSP00000215793

HPA

ENSG00000099995-SF3A1

PRO

Q15459

Pharos - Targets

Q15459

GlyGen

Q15459

PDB

8QPE, 8QXD, 7VPX, 8Q7N, 8QPK, 8QPB, 8QOZ, 8QZS, 8ID2, 6AHD, 8QP8, 7P08, 5Z56, 5Z57, 7ABG, 7EVO, 8QPA, 6AH0, 6Y53, 6FF7, 6QX9, 8R0B, 8H6J, 8H6K, 8CH6, 8QP9, 8HK1, 6Y5Q, 8H6E, 7P0V, 8R0A, 5Z58, 8H6L, 2DT6, 7VH9, 8RM5, 2DT7, 7ABI, 8QO9, 8R09, 8R08, 1ZKH

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.709	8
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.643	5
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.643	5
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.643	5
UniProt:O43143 DHX15	1	DHX15 [nucleoplasm] (R-HSA-5688097)	0.643	3
UniProt:O75400 PRPF40A	1	PRPF40A [nucleoplasm] (R-HSA-8867890)	0.632	3
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.615	3
UniProt:O75554 WBP4	1	WBP4 [nucleoplasm] (R-HSA-8867895)	0.573	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	3
UniProt:O75937 DNAJC8	1	DNAJC8 [nucleoplasm] (R-HSA-53703)	0.527	3
UniProt:P17900 GM2A	3	GM2A(32-193) [lysosomal lumen] (R-HSA-1605614) GM2A(32-193) [extracellular region] (R-HSA-6806181) GM2A(32-193) [azurophil granule lumen] (R-HSA-6799160)	0.527	2
UniProt:P02675 FGB	5	FGB [extracellular region] (R-HSA-140584) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [plasma membrane] (R-HSA-140917) FGB(31-491) [extracellular region] (R-HSA-140846) FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921)	0.527	2
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2
UniProt:Q15696 ZRSR2	1	ZRSR2 [nucleoplasm] (R-HSA-8865914)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	4
UniProt:Q15274 QPRT	1	QPRT [cytosol] (R-HSA-197212)	0.527	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.527	3
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.508	2
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.483	2

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