Reactome | PI(4,5)P2 [plasma membrane]

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PI(4,5)P2 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DDI-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] - Dictyostelium discoideum [Complex:R-DME-8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] - Drosophila melanogaster [Complex:R-CFA-418834] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] - Canis familiaris [Complex:R-DME-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-110453] Phosphorylation of PIP2 to PIP3 by Dp110 - Drosophila melanogaster [Reaction:R-SCE-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Saccharomyces cerevisiae [Reaction:R-SPO-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Schizosaccharomyces pombe [Reaction:R-DDI-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Dictyostelium discoideum [Reaction:R-CEL-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Caenorhabditis elegans [Reaction:R-DME-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Drosophila melanogaster [Reaction:R-GGA-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Gallus gallus [Reaction:R-SSC-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Sus scrofa [Reaction:R-BTA-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Bos taurus [Reaction:R-CFA-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Canis familiaris [Reaction:R-RNO-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Rattus norvegicus [Reaction:R-MMU-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Mus musculus [Reaction:R-HSA-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 - Homo sapiens [Reaction:R-HSA-9032478] EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Homo sapiens [Reaction:R-HSA-9680389] CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 - Homo sapiens [Reaction:R-HSA-434633] PIP2 binds inhibiting VAV - Homo sapiens [Reaction:R-HSA-5637801] Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII - Homo sapiens [Reaction:R-HSA-1226014] Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants - Homo sapiens [Reaction:R-HSA-9672162] PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers - Homo sapiens [Reaction:R-HSA-9672177] PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR - Homo sapiens [Reaction:R-HSA-2394007] PI3K gain of function mutants phosphorylate PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-2219536] AKT1 E17K mutant binds PIP2 - Homo sapiens [Reaction:R-HSA-9665407] PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-9664940] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-9664664] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-RNO-622387] PIP2 hydrolysis - Rattus norvegicus [Reaction:R-HSA-622382] PIP2 hydrolysis - Homo sapiens [Reaction:R-CEL-3928601] CDC42 and PIP2 bind WASL, activating it - Caenorhabditis elegans [Reaction:R-DME-3928601] CDC42 and PIP2 bind WASL, activating it - Drosophila melanogaster [Reaction:R-GGA-3928601] CDC42 and PIP2 bind WASL, activating it - Gallus gallus [Reaction:R-DRE-3928601] CDC42 and PIP2 bind WASL, activating it - Danio rerio [Reaction:R-SSC-3928601] CDC42 and PIP2 bind WASL, activating it - Sus scrofa [Reaction:R-BTA-3928601] CDC42 and PIP2 bind WASL, activating it - Bos taurus [Reaction:R-CFA-3928601] CDC42 and PIP2 bind WASL, activating it - Canis familiaris [Reaction:R-RNO-3928601] CDC42 and PIP2 bind WASL, activating it - Rattus norvegicus [Reaction:R-MMU-3928601] CDC42 and PIP2 bind WASL, activating it - Mus musculus [Reaction:R-HSA-3928601] CDC42 and PIP2 bind WASL, activating it - Homo sapiens [BlackBoxEvent:R-MMU-9031553] Activated Ntrk2 activates PI3K signaling - Mus musculus [BlackBoxEvent:R-HSA-9028519] NTRK2-activated PI3K generates PIP3 - Homo sapiens [BlackBoxEvent:R-NUL-9616944] Activated Ntrk3 stimulates PI3K activity - Mus musculus [BlackBoxEvent:R-HSA-9603445] Activated NTRK3 stimulates PI3K activity - Homo sapiens [Reaction:R-DME-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-DRE-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Danio rerio [Reaction:R-SSC-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Homo sapiens [Reaction:R-CEL-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Caenorhabditis elegans [Reaction:R-CEL-8852019] MET bound PI3K generates PIP3 - Caenorhabditis elegans [Reaction:R-XTR-8852019] MET bound PI3K generates PIP3 - Xenopus tropicalis [Reaction:R-SSC-8852019] MET bound PI3K generates PIP3 - Sus scrofa [Reaction:R-BTA-8852019] MET bound PI3K generates PIP3 - Bos taurus [Reaction:R-CFA-8852019] MET bound PI3K generates PIP3 - Canis familiaris [Reaction:R-RNO-8852019] MET bound PI3K generates PIP3 - Rattus norvegicus [Reaction:R-MMU-8852019] MET bound PI3K generates PIP3 - Mus musculus [Reaction:R-HSA-8852019] MET bound PI3K generates PIP3 - Homo sapiens [Reaction:R-GGA-8852019] MET bound PI3K generates PIP3 - Gallus gallus [Reaction:R-DME-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-RNO-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-CFA-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-DME-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-RNO-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-CFA-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-HSA-9670156] PtdIns(4,5)P2 binds WASP, N-WASP - Homo sapiens [Reaction:R-CEL-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Caenorhabditis elegans [Reaction:R-DME-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Drosophila melanogaster [Reaction:R-GGA-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Gallus gallus [Reaction:R-XTR-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Xenopus tropicalis [Reaction:R-SSC-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Sus scrofa [Reaction:R-BTA-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Bos taurus [Reaction:R-CFA-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Canis familiaris [Reaction:R-RNO-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Rattus norvegicus [Reaction:R-MMU-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Mus musculus [Reaction:R-HSA-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Homo sapiens [Reaction:R-CEL-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Caenorhabditis elegans [Reaction:R-DME-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Drosophila melanogaster [Reaction:R-GGA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Gallus gallus [Reaction:R-DRE-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Danio rerio [Reaction:R-SSC-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Sus scrofa [Reaction:R-BTA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Bos taurus [Reaction:R-CFA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Canis familiaris [Reaction:R-RNO-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Rattus norvegicus [Reaction:R-MMU-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Mus musculus [Reaction:R-HSA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Homo sapiens [Reaction:R-CEL-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Caenorhabditis elegans [Reaction:R-DME-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Drosophila melanogaster [Reaction:R-GGA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Gallus gallus [Reaction:R-XTR-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Xenopus tropicalis [Reaction:R-DRE-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Danio rerio [Reaction:R-SSC-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Sus scrofa [Reaction:R-BTA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Bos taurus [Reaction:R-CFA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Canis familiaris [Reaction:R-RNO-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Rattus norvegicus [Reaction:R-MMU-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Mus musculus [Reaction:R-HSA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 - Homo sapiens [Reaction:R-GGA-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Gallus gallus [Reaction:R-XTR-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Xenopus tropicalis [Reaction:R-SSC-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Sus scrofa [Reaction:R-BTA-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Bos taurus [Reaction:R-CFA-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Canis familiaris [Reaction:R-RNO-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Rattus norvegicus [Reaction:R-HSA-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Homo sapiens [Reaction:R-MMU-2559456] TIRAP binds PIP2-rich regions in the plasma membrane - Mus musculus [Reaction:R-GGA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-SSC-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-DDI-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Dictyostelium discoideum [Reaction:R-CEL-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Caenorhabditis elegans [Reaction:R-DME-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-DRE-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Danio rerio [Reaction:R-SSC-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 - Homo sapiens [Reaction:R-DME-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Drosophila melanogaster [Reaction:R-GGA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Gallus gallus [Reaction:R-DRE-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Danio rerio [Reaction:R-SSC-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Sus scrofa [Reaction:R-BTA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Bos taurus [Reaction:R-CFA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Canis familiaris [Reaction:R-RNO-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Rattus norvegicus [Reaction:R-MMU-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Mus musculus [Reaction:R-HSA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Homo sapiens [Reaction:R-DME-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Drosophila melanogaster [Reaction:R-SSC-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Sus scrofa [Reaction:R-BTA-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Bos taurus [Reaction:R-CFA-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Canis familiaris [Reaction:R-RNO-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Rattus norvegicus [Reaction:R-MMU-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Mus musculus [Reaction:R-HSA-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Homo sapiens [Reaction:R-GGA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-GGA-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate - Gallus gallus [Reaction:R-SSC-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate - Sus scrofa [Reaction:R-BTA-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate - Bos taurus [Reaction:R-CFA-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate - Canis familiaris [Reaction:R-RNO-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate - Rattus norvegicus [Reaction:R-MMU-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate - Mus musculus [Reaction:R-HSA-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate - Homo sapiens [Reaction:R-PFA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Plasmodium falciparum [Reaction:R-SCE-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Saccharomyces cerevisiae [Reaction:R-SPO-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Schizosaccharomyces pombe [Reaction:R-DDI-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Dictyostelium discoideum [Reaction:R-CEL-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Caenorhabditis elegans [Reaction:R-DME-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Drosophila melanogaster [Reaction:R-GGA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Gallus gallus [Reaction:R-XTR-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Xenopus tropicalis [Reaction:R-DRE-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Danio rerio [Reaction:R-SSC-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Sus scrofa [Reaction:R-BTA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Bos taurus [Reaction:R-CFA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Canis familiaris [Reaction:R-RNO-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Rattus norvegicus [Reaction:R-MMU-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Mus musculus [Reaction:R-HSA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Homo sapiens [Reaction:R-SCE-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Saccharomyces cerevisiae [Reaction:R-SPO-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Schizosaccharomyces pombe [Reaction:R-DDI-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Dictyostelium discoideum [Reaction:R-DME-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Drosophila melanogaster [Reaction:R-GGA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Gallus gallus [Reaction:R-SSC-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Sus scrofa [Reaction:R-BTA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Bos taurus [Reaction:R-CFA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Canis familiaris [Reaction:R-RNO-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Rattus norvegicus [Reaction:R-MMU-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Mus musculus [Reaction:R-HSA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Homo sapiens [Reaction:R-DME-398193] PLC beta-mediated PIP2 hydrolysis - Drosophila melanogaster [Reaction:R-GGA-398193] PLC beta-mediated PIP2 hydrolysis - Gallus gallus [Reaction:R-XTR-398193] PLC beta-mediated PIP2 hydrolysis - Xenopus tropicalis [Reaction:R-SSC-398193] PLC beta-mediated PIP2 hydrolysis - Sus scrofa [Reaction:R-BTA-398193] PLC beta-mediated PIP2 hydrolysis - Bos taurus [Reaction:R-CFA-398193] PLC beta-mediated PIP2 hydrolysis - Canis familiaris [Reaction:R-MMU-398193] PLC beta-mediated PIP2 hydrolysis - Mus musculus [Reaction:R-HSA-398193] PLC beta-mediated PIP2 hydrolysis - Homo sapiens [Reaction:R-SCE-111879] PIP2 hydrolysis - Saccharomyces cerevisiae [Reaction:R-SPO-111879] PIP2 hydrolysis - Schizosaccharomyces pombe [Reaction:R-DDI-111879] PIP2 hydrolysis - Dictyostelium discoideum [Reaction:R-CEL-111879] PIP2 hydrolysis - Caenorhabditis elegans [Reaction:R-DME-111879] PIP2 hydrolysis - Drosophila melanogaster [Reaction:R-GGA-111879] PIP2 hydrolysis - Gallus gallus [Reaction:R-XTR-111879] PIP2 hydrolysis - Xenopus tropicalis [Reaction:R-SSC-111879] PIP2 hydrolysis - Sus scrofa [Reaction:R-BTA-111879] PIP2 hydrolysis - Bos taurus [Reaction:R-CFA-111879] PIP2 hydrolysis - Canis familiaris [Reaction:R-RNO-111879] PIP2 hydrolysis - Rattus norvegicus [Reaction:R-MMU-111879] PIP2 hydrolysis - Mus musculus [Reaction:R-HSA-111879] PIP2 hydrolysis - Homo sapiens [Reaction:R-PFA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Plasmodium falciparum [Reaction:R-SCE-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Saccharomyces cerevisiae [Reaction:R-SPO-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Schizosaccharomyces pombe [Reaction:R-DDI-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Dictyostelium discoideum [Reaction:R-CEL-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Caenorhabditis elegans [Reaction:R-DME-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Drosophila melanogaster [Reaction:R-GGA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Gallus gallus [Reaction:R-XTR-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Xenopus tropicalis [Reaction:R-SSC-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Sus scrofa [Reaction:R-BTA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Bos taurus [Reaction:R-CFA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Canis familiaris [Reaction:R-RNO-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Rattus norvegicus [Reaction:R-MMU-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Mus musculus [Reaction:R-RNO-2316434] PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-CFA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Canis familiaris [Reaction:R-PFA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Plasmodium falciparum [Reaction:R-SCE-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Saccharomyces cerevisiae [Reaction:R-SPO-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Schizosaccharomyces pombe [Reaction:R-DDI-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Dictyostelium discoideum [Reaction:R-DDI-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Dictyostelium discoideum [Reaction:R-CEL-2316434] PI3K phosphorylates PIP2 to PIP3 - Caenorhabditis elegans [Reaction:R-CEL-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Caenorhabditis elegans [Reaction:R-DME-198266] PI3K produces PIP3 and other phosphatidyl inositides - Drosophila melanogaster [Reaction:R-DME-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Drosophila melanogaster [Reaction:R-DME-2316434] PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-DME-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Drosophila melanogaster [Reaction:R-GGA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Gallus gallus [Reaction:R-GGA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Gallus gallus [Reaction:R-GGA-2316434] PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-GGA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Gallus gallus [Reaction:R-XTR-198266] PI3K produces PIP3 and other phosphatidyl inositides - Xenopus tropicalis [Reaction:R-XTR-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Xenopus tropicalis [Reaction:R-XTR-2316434] PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-XTR-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Xenopus tropicalis [Reaction:R-DRE-2316434] PI3K phosphorylates PIP2 to PIP3 - Danio rerio [Reaction:R-DRE-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Danio rerio [Reaction:R-SSC-198266] PI3K produces PIP3 and other phosphatidyl inositides - Sus scrofa [Reaction:R-SSC-2316434] PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-SSC-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Sus scrofa [Reaction:R-SSC-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Sus scrofa [Reaction:R-MMU-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Mus musculus [Reaction:R-HSA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Homo sapiens [Reaction:R-BTA-2316434] PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-BTA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Bos taurus [Reaction:R-BTA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Bos taurus [Reaction:R-BTA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Bos taurus [Reaction:R-RNO-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Rattus norvegicus [Reaction:R-CFA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Canis familiaris [Reaction:R-CFA-2316434] PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-CFA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Canis familiaris [Reaction:R-MMU-2316434] PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-198266] PI3K produces PIP3 and other phosphatidyl inositides - Mus musculus [Reaction:R-HSA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Homo sapiens [Reaction:R-RNO-198266] PI3K produces PIP3 and other phosphatidyl inositides - Rattus norvegicus [Reaction:R-RNO-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Rattus norvegicus [Reaction:R-MMU-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Mus musculus [Reaction:R-HSA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Homo sapiens [Reaction:R-PFA-202354] Translocation of PLC-gamma1 to PIP2 - Plasmodium falciparum [Reaction:R-SCE-202354] Translocation of PLC-gamma1 to PIP2 - Saccharomyces cerevisiae [Reaction:R-SPO-202354] Translocation of PLC-gamma1 to PIP2 - Schizosaccharomyces pombe [Reaction:R-DDI-202354] Translocation of PLC-gamma1 to PIP2 - Dictyostelium discoideum [Reaction:R-DME-202354] Translocation of PLC-gamma1 to PIP2 - Drosophila melanogaster [Reaction:R-GGA-202354] Translocation of PLC-gamma1 to PIP2 - Gallus gallus [Reaction:R-XTR-202354] Translocation of PLC-gamma1 to PIP2 - Xenopus tropicalis [Reaction:R-DRE-202354] Translocation of PLC-gamma1 to PIP2 - Danio rerio [Reaction:R-SSC-202354] Translocation of PLC-gamma1 to PIP2 - Sus scrofa [Reaction:R-BTA-202354] Translocation of PLC-gamma1 to PIP2 - Bos taurus [Reaction:R-CFA-202354] Translocation of PLC-gamma1 to PIP2 - Canis familiaris [Reaction:R-RNO-202354] Translocation of PLC-gamma1 to PIP2 - Rattus norvegicus [Reaction:R-MMU-202354] Translocation of PLC-gamma1 to PIP2 - Mus musculus [Reaction:R-HSA-202354] Translocation of PLC-gamma1 to PIP2 - Homo sapiens [Reaction:R-RNO-182061] Active Plcg1 hydrolyses PIP2 - Rattus norvegicus [Reaction:R-HSA-167686] Active PLCG1 hydrolyses PIP2 - Homo sapiens [Reaction:R-PFA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Plasmodium falciparum [Reaction:R-SCE-114689] PLC gamma 2-mediated PIP2 hydrolysis - Saccharomyces cerevisiae [Reaction:R-SPO-114689] PLC gamma 2-mediated PIP2 hydrolysis - Schizosaccharomyces pombe [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Homo sapiens [Reaction:R-MMU-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Mus musculus [Reaction:R-RNO-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Rattus norvegicus [Reaction:R-CFA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Canis familiaris [Reaction:R-BTA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Bos taurus [Reaction:R-SSC-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Sus scrofa [Reaction:R-DRE-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Danio rerio [Reaction:R-XTR-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Xenopus tropicalis [Reaction:R-GGA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Gallus gallus [Reaction:R-DME-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Drosophila melanogaster [Reaction:R-CEL-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) - Caenorhabditis elegans [Reaction:R-HSA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Homo sapiens [Reaction:R-HSA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Homo sapiens [Reaction:R-MMU-114689] PLC gamma 2-mediated PIP2 hydrolysis - Mus musculus [Reaction:R-RNO-114689] PLC gamma 2-mediated PIP2 hydrolysis - Rattus norvegicus [Reaction:R-CFA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Canis familiaris [Reaction:R-BTA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Bos taurus [Reaction:R-SSC-114689] PLC gamma 2-mediated PIP2 hydrolysis - Sus scrofa [Reaction:R-XTR-114689] PLC gamma 2-mediated PIP2 hydrolysis - Xenopus tropicalis [Reaction:R-GGA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Gallus gallus [Reaction:R-DME-114689] PLC gamma 2-mediated PIP2 hydrolysis - Drosophila melanogaster [Reaction:R-DDI-114689] PLC gamma 2-mediated PIP2 hydrolysis - Dictyostelium discoideum [Reaction:R-DME-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-XTR-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-MMU-9032476] Epor-associated Plcg hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Mus musculus [Reaction:R-NUL-9717576] Gnb1:GNG2:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG - Bos taurus [Reaction:R-HSA-9717205] GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG - Homo sapiens [Reaction:R-MMU-9682182] Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate - Mus musculus [Reaction:R-MMU-434634] PIP2 inhibits Vav1 - Mus musculus [Reaction:R-DRE-2731138] Syndecan-4 binds PI(4,5)P2 - Danio rerio [Reaction:R-HSA-2731147] Syndecan-4 binds PI(4,5)P2 - Homo sapiens [Reaction:R-HSA-9712084] PI3K synthesizes PIP3 downstream of ALK mutants - Homo sapiens [Reaction:R-CEL-201510] PI3K synthesizes PIP3 downstream of ALK - Caenorhabditis elegans [Reaction:R-DME-201510] PI3K synthesizes PIP3 downstream of ALK - Drosophila melanogaster [Reaction:R-GGA-201510] PI3K synthesizes PIP3 downstream of ALK - Gallus gallus [Reaction:R-XTR-201510] PI3K synthesizes PIP3 downstream of ALK - Xenopus tropicalis [Reaction:R-DRE-201510] PI3K synthesizes PIP3 downstream of ALK - Danio rerio [Reaction:R-SSC-201510] PI3K synthesizes PIP3 downstream of ALK - Sus scrofa [Reaction:R-BTA-201510] PI3K synthesizes PIP3 downstream of ALK - Bos taurus [Reaction:R-CFA-201510] PI3K synthesizes PIP3 downstream of ALK - Canis familiaris [Reaction:R-RNO-201510] PI3K synthesizes PIP3 downstream of ALK - Rattus norvegicus [Reaction:R-MMU-201510] PI3K synthesizes PIP3 downstream of ALK - Mus musculus [Reaction:R-HSA-201510] PI3K synthesizes PIP3 downstream of ALK - Homo sapiens [Reaction:R-HSA-9670433] KIT mutants:PI3K catalyze synthesis of PIP3 - Homo sapiens [Reaction:R-HSA-5655235] Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-5655323] Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-5655289] Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-5655290] Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-HSA-1839107] BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. - Homo sapiens [Reaction:R-CEL-374662] Translocation of Ezrin to plasma membrane - Caenorhabditis elegans [Reaction:R-DME-374662] Translocation of Ezrin to plasma membrane - Drosophila melanogaster [Reaction:R-GGA-374662] Translocation of Ezrin to plasma membrane - Gallus gallus [Reaction:R-XTR-374662] Translocation of Ezrin to plasma membrane - Xenopus tropicalis [Reaction:R-DRE-374662] Translocation of Ezrin to plasma membrane - Danio rerio [Reaction:R-SSC-374662] Translocation of Ezrin to plasma membrane - Sus scrofa [Reaction:R-BTA-374662] Translocation of Ezrin to plasma membrane - Bos taurus [Reaction:R-CFA-374662] Translocation of Ezrin to plasma membrane - Canis familiaris [Reaction:R-RNO-374662] Translocation of Ezrin to plasma membrane - Rattus norvegicus [Reaction:R-MMU-374662] Translocation of Ezrin to plasma membrane - Mus musculus [Reaction:R-HSA-374662] Translocation of Ezrin to plasma membrane - Homo sapiens [Reaction:R-DME-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-DME-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-CEL-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 - Caenorhabditis elegans [Reaction:R-DME-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-DME-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-DME-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Drosophila melanogaster [Reaction:R-GGA-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Gallus gallus [Reaction:R-XTR-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Xenopus tropicalis [Reaction:R-DRE-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Danio rerio [Reaction:R-SSC-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Sus scrofa [Reaction:R-BTA-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Bos taurus [Reaction:R-CFA-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Canis familiaris [Reaction:R-RNO-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Rattus norvegicus [Reaction:R-MMU-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Mus musculus [Reaction:R-HSA-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Homo sapiens [Reaction:R-CEL-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers - Caenorhabditis elegans [Reaction:R-GGA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-DME-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-CEL-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Caenorhabditis elegans [Reaction:R-GGA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-DRE-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Danio rerio [Reaction:R-SSC-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-DME-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-CEL-1433514] Synthesis of PIP3 from PIP2 by PI3K - Caenorhabditis elegans [Reaction:R-GGA-1433514] Synthesis of PIP3 from PIP2 by PI3K - Gallus gallus [Reaction:R-XTR-1433514] Synthesis of PIP3 from PIP2 by PI3K - Xenopus tropicalis [Reaction:R-SSC-1433514] Synthesis of PIP3 from PIP2 by PI3K - Sus scrofa [Reaction:R-BTA-1433514] Synthesis of PIP3 from PIP2 by PI3K - Bos taurus [Reaction:R-CFA-1433514] Synthesis of PIP3 from PIP2 by PI3K - Canis familiaris [Reaction:R-RNO-1433514] Synthesis of PIP3 from PIP2 by PI3K - Rattus norvegicus [Reaction:R-MMU-1433514] Synthesis of PIP3 from PIP2 by PI3K - Mus musculus [Reaction:R-HSA-1433514] Synthesis of PIP3 from PIP2 by PI3K - Homo sapiens [Reaction:R-DRE-1433514] Synthesis of PIP3 from PIP2 by PI3K - Danio rerio [Reaction:R-GGA-2424480] PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-SSC-2424480] PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-2424480] PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-2424480] PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-MMU-2424480] PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-2424480] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-RNO-2424480] PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-DME-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Rattus norvegicus [Reaction:R-HSA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Homo sapiens [Reaction:R-MMU-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 - Mus musculus [Reaction:R-MMU-442572] Activation of WASP and N-WASP by CDC42 - Mus musculus [Reaction:R-HSA-442586] Activation of WASP and N-WASP by CDC42 - Homo sapiens [Reaction:R-CEL-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Caenorhabditis elegans [Reaction:R-DME-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-DRE-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Danio rerio [Reaction:R-SSC-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-PFA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Plasmodium falciparum [Reaction:R-SCE-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Saccharomyces cerevisiae [Reaction:R-SPO-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Schizosaccharomyces pombe [Reaction:R-DDI-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Dictyostelium discoideum [Reaction:R-DME-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Drosophila melanogaster [Reaction:R-GGA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Gallus gallus [Reaction:R-XTR-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Xenopus tropicalis [Reaction:R-SSC-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Sus scrofa [Reaction:R-BTA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Bos taurus [Reaction:R-CFA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Canis familiaris [Reaction:R-RNO-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Rattus norvegicus [Reaction:R-MMU-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Mus musculus [Reaction:R-HSA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Homo sapiens [Reaction:R-PFA-2219524] PDPK1 binds PIP2 - Plasmodium falciparum [Reaction:R-SCE-2219524] PDPK1 binds PIP2 - Saccharomyces cerevisiae [Reaction:R-SPO-2219524] PDPK1 binds PIP2 - Schizosaccharomyces pombe [Reaction:R-DDI-2219524] PDPK1 binds PIP2 - Dictyostelium discoideum [Reaction:R-CEL-2219524] PDPK1 binds PIP2 - Caenorhabditis elegans [Reaction:R-DME-2219524] PDPK1 binds PIP2 - Drosophila melanogaster [Reaction:R-GGA-2219524] PDPK1 binds PIP2 - Gallus gallus [Reaction:R-XTR-2219524] PDPK1 binds PIP2 - Xenopus tropicalis [Reaction:R-DRE-2219524] PDPK1 binds PIP2 - Danio rerio [Reaction:R-SSC-2219524] PDPK1 binds PIP2 - Sus scrofa [Reaction:R-BTA-2219524] PDPK1 binds PIP2 - Bos taurus [Reaction:R-CFA-2219524] PDPK1 binds PIP2 - Canis familiaris [Reaction:R-RNO-2219524] PDPK1 binds PIP2 - Rattus norvegicus [Reaction:R-MMU-2219524] PDPK1 binds PIP2 - Mus musculus [Reaction:R-HSA-2219524] PDPK1 binds PIP2 - Homo sapiens [Reaction:R-DME-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Drosophila melanogaster [Reaction:R-GGA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Gallus gallus [Reaction:R-XTR-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Xenopus tropicalis [Reaction:R-SSC-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Sus scrofa [Reaction:R-BTA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Bos taurus [Reaction:R-CFA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Canis familiaris [Reaction:R-RNO-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Rattus norvegicus [Reaction:R-MMU-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Mus musculus [Reaction:R-HSA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Homo sapiens [Reaction:R-DME-2730847] Hydrolysis of PIP2 by PLCG - Drosophila melanogaster [Reaction:R-GGA-2730847] Hydrolysis of PIP2 by PLCG - Gallus gallus [Reaction:R-XTR-2730847] Hydrolysis of PIP2 by PLCG - Xenopus tropicalis [Reaction:R-SSC-2730847] Hydrolysis of PIP2 by PLCG - Sus scrofa [Reaction:R-BTA-2730847] Hydrolysis of PIP2 by PLCG - Bos taurus [Reaction:R-CFA-2730847] Hydrolysis of PIP2 by PLCG - Canis familiaris [Reaction:R-RNO-2730847] Hydrolysis of PIP2 by PLCG - Rattus norvegicus [Reaction:R-MMU-2730847] Hydrolysis of PIP2 by PLCG - Mus musculus [Reaction:R-HSA-2730847] Hydrolysis of PIP2 by PLCG - Homo sapiens [Reaction:R-DDI-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Dictyostelium discoideum [Reaction:R-DME-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Homo sapiens [Reaction:R-PFA-202407] PLC-gamma1 hydrolyses PIP2 - Plasmodium falciparum [Reaction:R-SCE-202407] PLC-gamma1 hydrolyses PIP2 - Saccharomyces cerevisiae [Reaction:R-SPO-202407] PLC-gamma1 hydrolyses PIP2 - Schizosaccharomyces pombe [Reaction:R-DDI-202407] PLC-gamma1 hydrolyses PIP2 - Dictyostelium discoideum [Reaction:R-DME-202407] PLC-gamma1 hydrolyses PIP2 - Drosophila melanogaster [Reaction:R-GGA-202407] PLC-gamma1 hydrolyses PIP2 - Gallus gallus [Reaction:R-XTR-202407] PLC-gamma1 hydrolyses PIP2 - Xenopus tropicalis [Reaction:R-DRE-202407] PLC-gamma1 hydrolyses PIP2 - Danio rerio [Reaction:R-SSC-202407] PLC-gamma1 hydrolyses PIP2 - Sus scrofa [Reaction:R-BTA-202407] PLC-gamma1 hydrolyses PIP2 - Bos taurus [Reaction:R-CFA-202407] PLC-gamma1 hydrolyses PIP2 - Canis familiaris [Reaction:R-RNO-202407] PLC-gamma1 hydrolyses PIP2 - Rattus norvegicus [Reaction:R-MMU-202407] PLC-gamma1 hydrolyses PIP2 - Mus musculus [Reaction:R-HSA-202407] PLC-gamma1 hydrolyses PIP2 - Homo sapiens [Reaction:R-GGA-2029271] PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-SSC-2029271] PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-2029271] PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-2029271] PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-2029271] PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-2029271] PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-HSA-2029271] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [Reaction:R-CEL-354060] Translocation of RIAM to plasma membrane - Caenorhabditis elegans [Reaction:R-DME-354060] Translocation of RIAM to plasma membrane - Drosophila melanogaster [Reaction:R-GGA-354060] Translocation of RIAM to plasma membrane - Gallus gallus [Reaction:R-XTR-354060] Translocation of RIAM to plasma membrane - Xenopus tropicalis [Reaction:R-DRE-354060] Translocation of RIAM to plasma membrane - Danio rerio [Reaction:R-SSC-354060] Translocation of RIAM to plasma membrane - Sus scrofa [Reaction:R-BTA-354060] Translocation of RIAM to plasma membrane - Bos taurus [Reaction:R-CFA-354060] Translocation of RIAM to plasma membrane - Canis familiaris [Reaction:R-RNO-354060] Translocation of RIAM to plasma membrane - Rattus norvegicus [Reaction:R-MMU-354060] Translocation of RIAM to plasma membrane - Mus musculus [Reaction:R-HSA-354060] Translocation of RIAM to plasma membrane - Homo sapiens [Reaction:R-DRE-418874] Recruitment and activation of N-WASP by Cdc42 - Danio rerio [Reaction:R-BTA-418874] Recruitment and activation of N-WASP by Cdc42 - Bos taurus [Reaction:R-CFA-418874] Recruitment and activation of N-WASP by Cdc42 - Canis familiaris [Reaction:R-HSA-418874] Recruitment and activation of N-WASP by Cdc42 - Homo sapiens [Reaction:R-CEL-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Caenorhabditis elegans [Reaction:R-DME-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Drosophila melanogaster [Reaction:R-SSC-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Sus scrofa [Reaction:R-BTA-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Bos taurus [Reaction:R-CFA-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Canis familiaris [Reaction:R-RNO-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Rattus norvegicus [Reaction:R-MMU-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Mus musculus [Reaction:R-HSA-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Homo sapiens
created	[InstanceEdit:179808] Jassal, Bijay, 2006-05-09
crossReference	[DatabaseIdentifier:36380] COMPOUND:C04637
dbId	179856
displayName	PI(4,5)P2 [plasma membrane]
inDisease	false
memberOf	[DefinedSet:R-ALL-8874460] PI(4,5)P2, PI(3,4,5)P3 [plasma membrane] [DefinedSet:R-ALL-5620974] PI4P,PI(4,5)P2,PIP3 [plasma membrane]
modified	[InstanceEdit:9760900] D'Eustachio, Peter, 2022-01-05
name	PI(4,5)P2 PIP2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Phosphatidylinositol-4,5-bisphosphate 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate
producedByEvent	[Reaction:R-DME-110459] PIP3 dephosphorylated to PIP2 by DPTEN - Drosophila melanogaster [Reaction:R-PFA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Plasmodium falciparum [Reaction:R-SCE-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Saccharomyces cerevisiae [Reaction:R-SPO-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Schizosaccharomyces pombe [Reaction:R-DDI-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Dictyostelium discoideum [Reaction:R-CEL-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Caenorhabditis elegans [Reaction:R-DME-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Drosophila melanogaster [Reaction:R-GGA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Gallus gallus [Reaction:R-XTR-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Xenopus tropicalis [Reaction:R-SSC-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Sus scrofa [Reaction:R-BTA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Bos taurus [Reaction:R-CFA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Canis familiaris [Reaction:R-RNO-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Rattus norvegicus [Reaction:R-MMU-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Mus musculus [Reaction:R-HSA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Homo sapiens [Reaction:R-PFA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Plasmodium falciparum [Reaction:R-PFA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Plasmodium falciparum [Reaction:R-SCE-199456] PTEN dephosphorylates PIP3 - Saccharomyces cerevisiae [Reaction:R-SCE-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Saccharomyces cerevisiae [Reaction:R-SCE-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Saccharomyces cerevisiae [Reaction:R-SPO-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Schizosaccharomyces pombe [Reaction:R-SPO-199456] PTEN dephosphorylates PIP3 - Schizosaccharomyces pombe [Reaction:R-SPO-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Schizosaccharomyces pombe [Reaction:R-DDI-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Dictyostelium discoideum [Reaction:R-DDI-199456] PTEN dephosphorylates PIP3 - Dictyostelium discoideum [Reaction:R-DDI-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Dictyostelium discoideum [Reaction:R-CEL-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-199456] PTEN dephosphorylates PIP3 - Caenorhabditis elegans [Reaction:R-CEL-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Caenorhabditis elegans [Reaction:R-DME-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Drosophila melanogaster [Reaction:R-DME-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Drosophila melanogaster [Reaction:R-DME-199456] PTEN dephosphorylates PIP3 - Drosophila melanogaster [Reaction:R-GGA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Gallus gallus [Reaction:R-GGA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Gallus gallus [Reaction:R-GGA-199456] PTEN dephosphorylates PIP3 - Gallus gallus [Reaction:R-XTR-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Xenopus tropicalis [Reaction:R-XTR-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Xenopus tropicalis [Reaction:R-XTR-199456] PTEN dephosphorylates PIP3 - Xenopus tropicalis [Reaction:R-DRE-199456] PTEN dephosphorylates PIP3 - Danio rerio [Reaction:R-DRE-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Danio rerio [Reaction:R-DRE-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Danio rerio [Reaction:R-SSC-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Sus scrofa [Reaction:R-SSC-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Sus scrofa [Reaction:R-SSC-199456] PTEN dephosphorylates PIP3 - Sus scrofa [Reaction:R-BTA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Bos taurus [Reaction:R-BTA-199456] PTEN dephosphorylates PIP3 - Bos taurus [Reaction:R-BTA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Bos taurus [Reaction:R-RNO-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Rattus norvegicus [Reaction:R-RNO-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Rattus norvegicus [Reaction:R-CFA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Canis familiaris [Reaction:R-CFA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Canis familiaris [Reaction:R-CFA-199456] PTEN dephosphorylates PIP3 - Canis familiaris [Reaction:R-MMU-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Mus musculus [Reaction:R-MMU-199456] PTEN dephosphorylates PIP3 - Mus musculus [Reaction:R-RNO-199456] PTEN dephosphorylates PIP3 - Rattus norvegicus [Reaction:R-MMU-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Mus musculus [Reaction:R-HSA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Homo sapiens [Reaction:R-HSA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Homo sapiens [Reaction:R-HSA-199456] PTEN dephosphorylates PIP3 - Homo sapiens [Reaction:R-CEL-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Caenorhabditis elegans [Reaction:R-DME-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Drosophila melanogaster [Reaction:R-GGA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Gallus gallus [Reaction:R-SSC-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Sus scrofa [Reaction:R-BTA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Bos taurus [Reaction:R-CFA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Canis familiaris [Reaction:R-RNO-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Rattus norvegicus [Reaction:R-MMU-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Mus musculus [Reaction:R-HSA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Homo sapiens
referenceEntity	[ReferenceMolecule:9760917] 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-) [ChEBI:58456]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-179856

Referrals

(hasComponent)	[Complex:R-DME-8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] [Complex:R-SSC-8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] [Complex:R-BTA-8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] [Complex:R-GGA-8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] [Complex:R-CFA-8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] [Complex:R-MMU-8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] [Complex:R-RNO-8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] [Complex:R-SPO-8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] [Complex:R-CEL-8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] [Complex:R-HSA-8868632] PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] [Complex:R-DDI-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-GGA-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-CEL-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-RNO-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-MMU-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-SPO-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-SSC-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-DME-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-CFA-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-SCE-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-BTA-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-HSA-8871153] PI(4,5)P2:AP-2:clathrin [plasma membrane] [Complex:R-DME-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-CFA-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-SPO-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-GGA-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-CEL-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-MMU-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-SSC-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-BTA-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-RNO-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-SCE-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-DDI-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-HSA-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] [Complex:R-MMU-434630] Vav1:PIP2 [cytosol] [Complex:R-RNO-434632] VAV family:PIP2 [plasma membrane] [Complex:R-MMU-434632] VAV family:PIP2 [plasma membrane] [Complex:R-SSC-434632] VAV family:PIP2 [plasma membrane] [Complex:R-DME-434632] VAV family:PIP2 [plasma membrane] [Complex:R-BTA-434632] VAV family:PIP2 [plasma membrane] [Complex:R-CEL-434632] VAV family:PIP2 [plasma membrane] [Complex:R-CFA-434632] VAV family:PIP2 [plasma membrane] [Complex:R-XTR-434632] VAV family:PIP2 [plasma membrane] [Complex:R-HSA-434632] VAV family:PIP2 [plasma membrane] [Complex:R-DRE-2731131] Sdc4:PI(4,5)P2 [plasma membrane] [Complex:R-DRE-2731080] Syndecan-4:PI(4,5)P2 [plasma membrane] [Complex:R-CFA-2731080] Syndecan-4:PI(4,5)P2 [plasma membrane] [Complex:R-SSC-2731080] Syndecan-4:PI(4,5)P2 [plasma membrane] [Complex:R-MMU-2731080] Syndecan-4:PI(4,5)P2 [plasma membrane] [Complex:R-BTA-2731080] Syndecan-4:PI(4,5)P2 [plasma membrane] [Complex:R-CEL-2731080] Syndecan-4:PI(4,5)P2 [plasma membrane] [Complex:R-DME-2731080] Syndecan-4:PI(4,5)P2 [plasma membrane] [Complex:R-GGA-2731080] Syndecan-4:PI(4,5)P2 [plasma membrane] [Complex:R-RNO-2731080] Syndecan-4:PI(4,5)P2 [plasma membrane] [Complex:R-HSA-2731080] Syndecan-4:PI(4,5)P2 [plasma membrane] [Complex:R-HSA-2243943] p-S473-AKT1 E17K mutant:PIP2 [plasma membrane] [Complex:R-HSA-2219527] AKT1 E17K mutant:PIP2 [plasma membrane] [Complex:R-CFA-418834] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] [Complex:R-BTA-418834] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] [Complex:R-DRE-418834] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] [Complex:R-HSA-418834] NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] [Complex:R-DRE-374570] EZR:PIP2 [plasma membrane] [Complex:R-SSC-374570] EZR:PIP2 [plasma membrane] [Complex:R-RNO-374570] EZR:PIP2 [plasma membrane] [Complex:R-MMU-374570] EZR:PIP2 [plasma membrane] [Complex:R-GGA-374570] EZR:PIP2 [plasma membrane] [Complex:R-CFA-374570] EZR:PIP2 [plasma membrane] [Complex:R-BTA-374570] EZR:PIP2 [plasma membrane] [Complex:R-DME-374570] EZR:PIP2 [plasma membrane] [Complex:R-XTR-374570] EZR:PIP2 [plasma membrane] [Complex:R-CEL-374570] EZR:PIP2 [plasma membrane] [Complex:R-HSA-374570] EZR:PIP2 [plasma membrane] [Complex:R-DME-374558] p-T567-EZR:PIP2 [plasma membrane] [Complex:R-GGA-374558] p-T567-EZR:PIP2 [plasma membrane] [Complex:R-XTR-374558] p-T567-EZR:PIP2 [plasma membrane] [Complex:R-CEL-374558] p-T567-EZR:PIP2 [plasma membrane] [Complex:R-DRE-374558] p-T567-EZR:PIP2 [plasma membrane] [Complex:R-SSC-374558] p-T567-EZR:PIP2 [plasma membrane] [Complex:R-BTA-374558] p-T567-EZR:PIP2 [plasma membrane] [Complex:R-MMU-374558] p-T567-EZR:PIP2 [plasma membrane] [Complex:R-RNO-374558] p-T567-EZR:PIP2 [plasma membrane] [Complex:R-CFA-374558] p-T567-EZR:PIP2 [plasma membrane] [Complex:R-HSA-374558] p-T567-EZR:PIP2 [plasma membrane] [Complex:R-CEL-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] [Complex:R-CFA-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] [Complex:R-SSC-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] [Complex:R-DRE-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] [Complex:R-DME-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] [Complex:R-BTA-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] [Complex:R-MMU-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] [Complex:R-GGA-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] [Complex:R-RNO-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] [Complex:R-HSA-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] [Complex:R-RNO-443665] ERM:PIP2 [plasma membrane] [Complex:R-RNO-443660] ERM:PIP2 [plasma membrane] [Complex:R-CEL-443660] ERM:PIP2 [plasma membrane] [Complex:R-XTR-443660] ERM:PIP2 [plasma membrane] [Complex:R-MMU-443660] ERM:PIP2 [plasma membrane] [Complex:R-HSA-443660] ERM:PIP2 [plasma membrane] [Complex:R-CFA-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Complex:R-BTA-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Complex:R-MMU-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Complex:R-DME-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Complex:R-GGA-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Complex:R-CEL-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Complex:R-RNO-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Complex:R-SSC-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Complex:R-HSA-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] [Complex:R-DME-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] [Complex:R-BTA-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] [Complex:R-SSC-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] [Complex:R-CEL-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] [Complex:R-CFA-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] [Complex:R-MMU-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] [Complex:R-RNO-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] [Complex:R-GGA-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] [Complex:R-HSA-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] [Complex:R-MMU-2029162] Cdc42-GTP:Wasp/N-Wasp [cytosol] [Complex:R-HSA-9667225] PI(4,5)P2:WASP/N-WASP [plasma membrane] [Complex:R-SSC-442584] CDC42:GTP:WASP/N-WASP [plasma membrane] [Complex:R-BTA-442584] CDC42:GTP:WASP/N-WASP [plasma membrane] [Complex:R-DRE-442584] CDC42:GTP:WASP/N-WASP [plasma membrane] [Complex:R-GGA-442584] CDC42:GTP:WASP/N-WASP [plasma membrane] [Complex:R-CFA-442584] CDC42:GTP:WASP/N-WASP [plasma membrane] [Complex:R-HSA-442584] CDC42:GTP:WASP/N-WASP [plasma membrane] [Complex:R-GGA-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] [Complex:R-DDI-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] [Complex:R-DME-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] [Complex:R-CEL-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] [Complex:R-RNO-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] [Complex:R-DRE-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] [Complex:R-MMU-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] [Complex:R-CFA-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] [Complex:R-SSC-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] [Complex:R-BTA-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] [Complex:R-HSA-2197680] CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] [Complex:R-CEL-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-SSC-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-DME-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-GGA-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-RNO-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-DRE-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-BTA-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-DDI-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-CFA-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-MMU-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-HSA-2197683] CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] [Complex:R-CEL-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-SCE-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-BTA-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-PFA-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-CFA-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-SSC-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-SPO-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-XTR-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-GGA-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-RNO-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-DRE-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-MMU-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-DDI-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-DME-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-HSA-2219520] PDPK1:PIP2 [plasma membrane] [Complex:R-GGA-2559415] TIRAP:PI(4,5)P2 [plasma membrane] [Complex:R-SSC-2559415] TIRAP:PI(4,5)P2 [plasma membrane] [Complex:R-RNO-2559415] TIRAP:PI(4,5)P2 [plasma membrane] [Complex:R-BTA-2559415] TIRAP:PI(4,5)P2 [plasma membrane] [Complex:R-XTR-2559415] TIRAP:PI(4,5)P2 [plasma membrane] [Complex:R-CFA-2559415] TIRAP:PI(4,5)P2 [plasma membrane] [Complex:R-MMU-2559415] TIRAP:PI(4,5)P2 [plasma membrane] [Complex:R-HSA-2559415] TIRAP:PI(4,5)P2 [plasma membrane] [Complex:R-HSA-5365824] p-4Y-TIRAP:PI(4,5)P2 [plasma membrane] [Complex:R-MMU-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-XTR-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-BTA-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-DDI-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-SPO-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-CEL-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-GGA-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-SSC-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-SCE-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-CFA-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-DME-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-RNO-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-HSA-8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Complex:R-DDI-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-SCE-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-MMU-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-SSC-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-XTR-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-RNO-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-BTA-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-DRE-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-PFA-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-CFA-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-GGA-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-SPO-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-DME-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-HSA-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane] [Complex:R-HSA-354132] Vinculin bound to PIP2 [plasma membrane] [Complex:R-BTA-354132] Vinculin bound to PIP2 [plasma membrane] [Complex:R-GGA-354132] Vinculin bound to PIP2 [plasma membrane] [Complex:R-RNO-354132] Vinculin bound to PIP2 [plasma membrane] [Complex:R-CEL-354132] Vinculin bound to PIP2 [plasma membrane] [Complex:R-CFA-354132] Vinculin bound to PIP2 [plasma membrane] [Complex:R-DME-354132] Vinculin bound to PIP2 [plasma membrane] [Complex:R-MMU-354132] Vinculin bound to PIP2 [plasma membrane] [Complex:R-SSC-354132] Vinculin bound to PIP2 [plasma membrane] [Complex:R-HSA-354110] Rap1-GTP:PIP2:RIAM [plasma membrane] [Complex:R-SSC-354110] Rap1-GTP:PIP2:RIAM [plasma membrane] [Complex:R-DME-354110] Rap1-GTP:PIP2:RIAM [plasma membrane] [Complex:R-GGA-354110] Rap1-GTP:PIP2:RIAM [plasma membrane] [Complex:R-XTR-354110] Rap1-GTP:PIP2:RIAM [plasma membrane] [Complex:R-RNO-354110] Rap1-GTP:PIP2:RIAM [plasma membrane] [Complex:R-DRE-354110] Rap1-GTP:PIP2:RIAM [plasma membrane] [Complex:R-CEL-354110] Rap1-GTP:PIP2:RIAM [plasma membrane] [Complex:R-MMU-354110] Rap1-GTP:PIP2:RIAM [plasma membrane] [Complex:R-BTA-354110] Rap1-GTP:PIP2:RIAM [plasma membrane] [Complex:R-CFA-354110] Rap1-GTP:PIP2:RIAM [plasma membrane]
(input)	[Reaction:R-DME-110453] Phosphorylation of PIP2 to PIP3 by Dp110 [Reaction:R-SCE-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-SPO-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-DDI-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-CEL-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-DME-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-GGA-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-SSC-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-BTA-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-CFA-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-RNO-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-MMU-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-HSA-8871196] Initial binding of AP-2 and clathrin to PI(4,5)P2 [Reaction:R-DME-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-9021627] EPOR-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-9032476] Epor-associated Plcg hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [Reaction:R-HSA-9032478] EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate [Reaction:R-NUL-9717576] Gnb1:GNG2:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG [Reaction:R-HSA-9717205] GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG [Reaction:R-MMU-9682182] Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate [Reaction:R-HSA-9680389] CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 [Reaction:R-MMU-434634] PIP2 inhibits Vav1 [Reaction:R-HSA-434633] PIP2 binds inhibiting VAV [Reaction:R-CEL-354060] Translocation of RIAM to plasma membrane [Reaction:R-DME-354060] Translocation of RIAM to plasma membrane [Reaction:R-GGA-354060] Translocation of RIAM to plasma membrane [Reaction:R-XTR-354060] Translocation of RIAM to plasma membrane [Reaction:R-DRE-354060] Translocation of RIAM to plasma membrane [Reaction:R-SSC-354060] Translocation of RIAM to plasma membrane [Reaction:R-BTA-354060] Translocation of RIAM to plasma membrane [Reaction:R-CFA-354060] Translocation of RIAM to plasma membrane [Reaction:R-RNO-354060] Translocation of RIAM to plasma membrane [Reaction:R-MMU-354060] Translocation of RIAM to plasma membrane [Reaction:R-HSA-354060] Translocation of RIAM to plasma membrane [Reaction:R-DRE-2731138] Syndecan-4 binds PI(4,5)P2 [Reaction:R-HSA-2731147] Syndecan-4 binds PI(4,5)P2 [Reaction:R-HSA-9712084] PI3K synthesizes PIP3 downstream of ALK mutants [Reaction:R-CEL-201510] PI3K synthesizes PIP3 downstream of ALK [Reaction:R-DME-201510] PI3K synthesizes PIP3 downstream of ALK [Reaction:R-GGA-201510] PI3K synthesizes PIP3 downstream of ALK [Reaction:R-XTR-201510] PI3K synthesizes PIP3 downstream of ALK [Reaction:R-DRE-201510] PI3K synthesizes PIP3 downstream of ALK [Reaction:R-SSC-201510] PI3K synthesizes PIP3 downstream of ALK [Reaction:R-BTA-201510] PI3K synthesizes PIP3 downstream of ALK [Reaction:R-CFA-201510] PI3K synthesizes PIP3 downstream of ALK [Reaction:R-RNO-201510] PI3K synthesizes PIP3 downstream of ALK [Reaction:R-MMU-201510] PI3K synthesizes PIP3 downstream of ALK [Reaction:R-HSA-201510] PI3K synthesizes PIP3 downstream of ALK [Reaction:R-HSA-5637801] Conversion of PIP2 to PIP3 by PI3K bound to phosphorylated EGFRvIII [Reaction:R-HSA-1226014] Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants [Reaction:R-HSA-9672162] PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers [Reaction:R-HSA-9672177] PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR [Reaction:R-HSA-2394007] PI3K gain of function mutants phosphorylate PIP2 to PIP3 [Reaction:R-HSA-2219536] AKT1 E17K mutant binds PIP2 [Reaction:R-HSA-9665407] PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3 [Reaction:R-HSA-9664940] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 [Reaction:R-HSA-9664664] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 [Reaction:R-HSA-9670433] KIT mutants:PI3K catalyze synthesis of PIP3 [Reaction:R-HSA-5655235] Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5655323] Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5655289] Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5655290] Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-1839107] BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3. [Reaction:R-HSA-1839091] Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-622387] PIP2 hydrolysis [Reaction:R-HSA-622382] PIP2 hydrolysis [Reaction:R-DRE-418874] Recruitment and activation of N-WASP by Cdc42 [Reaction:R-BTA-418874] Recruitment and activation of N-WASP by Cdc42 [Reaction:R-CFA-418874] Recruitment and activation of N-WASP by Cdc42 [Reaction:R-HSA-418874] Recruitment and activation of N-WASP by Cdc42 [Reaction:R-CEL-374662] Translocation of Ezrin to plasma membrane [Reaction:R-DME-374662] Translocation of Ezrin to plasma membrane [Reaction:R-GGA-374662] Translocation of Ezrin to plasma membrane [Reaction:R-XTR-374662] Translocation of Ezrin to plasma membrane [Reaction:R-DRE-374662] Translocation of Ezrin to plasma membrane [Reaction:R-SSC-374662] Translocation of Ezrin to plasma membrane [Reaction:R-BTA-374662] Translocation of Ezrin to plasma membrane [Reaction:R-CFA-374662] Translocation of Ezrin to plasma membrane [Reaction:R-RNO-374662] Translocation of Ezrin to plasma membrane [Reaction:R-MMU-374662] Translocation of Ezrin to plasma membrane [Reaction:R-HSA-374662] Translocation of Ezrin to plasma membrane [Reaction:R-CEL-3928601] CDC42 and PIP2 bind WASL, activating it [Reaction:R-DME-3928601] CDC42 and PIP2 bind WASL, activating it [Reaction:R-GGA-3928601] CDC42 and PIP2 bind WASL, activating it [Reaction:R-DRE-3928601] CDC42 and PIP2 bind WASL, activating it [Reaction:R-SSC-3928601] CDC42 and PIP2 bind WASL, activating it [Reaction:R-BTA-3928601] CDC42 and PIP2 bind WASL, activating it [Reaction:R-CFA-3928601] CDC42 and PIP2 bind WASL, activating it [Reaction:R-RNO-3928601] CDC42 and PIP2 bind WASL, activating it [Reaction:R-MMU-3928601] CDC42 and PIP2 bind WASL, activating it [Reaction:R-HSA-3928601] CDC42 and PIP2 bind WASL, activating it [Reaction:R-DME-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-GGA-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5654714] FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DME-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-GGA-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CEL-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DME-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-GGA-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5654697] FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DME-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-GGA-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5654701] FGFR2-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DME-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [Reaction:R-GGA-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [Reaction:R-XTR-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [Reaction:R-DRE-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [Reaction:R-SSC-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [Reaction:R-BTA-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [Reaction:R-CFA-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [Reaction:R-RNO-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [Reaction:R-MMU-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [Reaction:R-HSA-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [Reaction:R-CEL-1250370] Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers [BlackBoxEvent:R-MMU-9031553] Activated Ntrk2 activates PI3K signaling [BlackBoxEvent:R-HSA-9028519] NTRK2-activated PI3K generates PIP3 [BlackBoxEvent:R-NUL-9616944] Activated Ntrk3 stimulates PI3K activity [BlackBoxEvent:R-HSA-9603445] Activated NTRK3 stimulates PI3K activity [Reaction:R-DME-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Reaction:R-GGA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Reaction:R-XTR-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Reaction:R-DRE-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Reaction:R-SSC-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Reaction:R-BTA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Reaction:R-CFA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Reaction:R-RNO-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Reaction:R-MMU-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Reaction:R-HSA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Reaction:R-CEL-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 [Reaction:R-CEL-8852019] MET bound PI3K generates PIP3 [Reaction:R-XTR-8852019] MET bound PI3K generates PIP3 [Reaction:R-SSC-8852019] MET bound PI3K generates PIP3 [Reaction:R-BTA-8852019] MET bound PI3K generates PIP3 [Reaction:R-CFA-8852019] MET bound PI3K generates PIP3 [Reaction:R-RNO-8852019] MET bound PI3K generates PIP3 [Reaction:R-MMU-8852019] MET bound PI3K generates PIP3 [Reaction:R-HSA-8852019] MET bound PI3K generates PIP3 [Reaction:R-GGA-8852019] MET bound PI3K generates PIP3 [Reaction:R-GGA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DME-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CEL-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-GGA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DRE-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DME-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CEL-1433514] Synthesis of PIP3 from PIP2 by PI3K [Reaction:R-GGA-1433514] Synthesis of PIP3 from PIP2 by PI3K [Reaction:R-XTR-1433514] Synthesis of PIP3 from PIP2 by PI3K [Reaction:R-SSC-1433514] Synthesis of PIP3 from PIP2 by PI3K [Reaction:R-BTA-1433514] Synthesis of PIP3 from PIP2 by PI3K [Reaction:R-CFA-1433514] Synthesis of PIP3 from PIP2 by PI3K [Reaction:R-RNO-1433514] Synthesis of PIP3 from PIP2 by PI3K [Reaction:R-MMU-1433514] Synthesis of PIP3 from PIP2 by PI3K [Reaction:R-HSA-1433514] Synthesis of PIP3 from PIP2 by PI3K [Reaction:R-DRE-1433514] Synthesis of PIP3 from PIP2 by PI3K [Reaction:R-DME-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-GGA-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-5654705] FGFR3-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DME-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-GGA-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-5654709] FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 [Reaction:R-GGA-2424480] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-2424480] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-2424480] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-2424480] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-2424480] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-2424480] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-2424480] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DME-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Reaction:R-GGA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Reaction:R-XTR-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Reaction:R-SSC-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Reaction:R-BTA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Reaction:R-CFA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Reaction:R-RNO-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Reaction:R-HSA-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Reaction:R-MMU-109699] PI3K-containing complexes phosphorylate PIP2 to PIP3 [Reaction:R-CEL-8867044] EGFR binds EPS15, EPN1, EPS15L1 [Reaction:R-DME-8867044] EGFR binds EPS15, EPN1, EPS15L1 [Reaction:R-SSC-8867044] EGFR binds EPS15, EPN1, EPS15L1 [Reaction:R-BTA-8867044] EGFR binds EPS15, EPN1, EPS15L1 [Reaction:R-CFA-8867044] EGFR binds EPS15, EPN1, EPS15L1 [Reaction:R-RNO-8867044] EGFR binds EPS15, EPN1, EPS15L1 [Reaction:R-MMU-8867044] EGFR binds EPS15, EPN1, EPS15L1 [Reaction:R-HSA-8867044] EGFR binds EPS15, EPN1, EPS15L1 [Reaction:R-MMU-442572] Activation of WASP and N-WASP by CDC42 [Reaction:R-HSA-442586] Activation of WASP and N-WASP by CDC42 [Reaction:R-HSA-9670156] PtdIns(4,5)P2 binds WASP, N-WASP [Reaction:R-CEL-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DME-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Reaction:R-GGA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DRE-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CEL-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-DME-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-GGA-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-XTR-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-SSC-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-BTA-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-CFA-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-RNO-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-MMU-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-HSA-1306957] PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR [Reaction:R-CEL-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-DME-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-GGA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-DRE-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-SSC-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-BTA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-CFA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-RNO-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-MMU-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-HSA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 [Reaction:R-CEL-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-DME-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-GGA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-XTR-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-DRE-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-SSC-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-BTA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-CFA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-RNO-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-MMU-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-HSA-1306979] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 [Reaction:R-GGA-2559456] TIRAP binds PIP2-rich regions in the plasma membrane [Reaction:R-XTR-2559456] TIRAP binds PIP2-rich regions in the plasma membrane [Reaction:R-SSC-2559456] TIRAP binds PIP2-rich regions in the plasma membrane [Reaction:R-BTA-2559456] TIRAP binds PIP2-rich regions in the plasma membrane [Reaction:R-CFA-2559456] TIRAP binds PIP2-rich regions in the plasma membrane [Reaction:R-RNO-2559456] TIRAP binds PIP2-rich regions in the plasma membrane [Reaction:R-HSA-2559456] TIRAP binds PIP2-rich regions in the plasma membrane [Reaction:R-MMU-2559456] TIRAP binds PIP2-rich regions in the plasma membrane [Reaction:R-PFA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-SCE-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-SPO-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-DDI-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-DME-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-GGA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-XTR-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-SSC-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-BTA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-CFA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-RNO-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-MMU-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-HSA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 [Reaction:R-PFA-2219524] PDPK1 binds PIP2 [Reaction:R-SCE-2219524] PDPK1 binds PIP2 [Reaction:R-SPO-2219524] PDPK1 binds PIP2 [Reaction:R-DDI-2219524] PDPK1 binds PIP2 [Reaction:R-CEL-2219524] PDPK1 binds PIP2 [Reaction:R-DME-2219524] PDPK1 binds PIP2 [Reaction:R-GGA-2219524] PDPK1 binds PIP2 [Reaction:R-XTR-2219524] PDPK1 binds PIP2 [Reaction:R-DRE-2219524] PDPK1 binds PIP2 [Reaction:R-SSC-2219524] PDPK1 binds PIP2 [Reaction:R-BTA-2219524] PDPK1 binds PIP2 [Reaction:R-CFA-2219524] PDPK1 binds PIP2 [Reaction:R-RNO-2219524] PDPK1 binds PIP2 [Reaction:R-MMU-2219524] PDPK1 binds PIP2 [Reaction:R-HSA-2219524] PDPK1 binds PIP2 [Reaction:R-DME-2730870] Phosphorylation of PIP2 to PIP3 by PI3K [Reaction:R-GGA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K [Reaction:R-XTR-2730870] Phosphorylation of PIP2 to PIP3 by PI3K [Reaction:R-SSC-2730870] Phosphorylation of PIP2 to PIP3 by PI3K [Reaction:R-BTA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K [Reaction:R-CFA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K [Reaction:R-RNO-2730870] Phosphorylation of PIP2 to PIP3 by PI3K [Reaction:R-MMU-2730870] Phosphorylation of PIP2 to PIP3 by PI3K [Reaction:R-HSA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K [Reaction:R-DME-2730847] Hydrolysis of PIP2 by PLCG [Reaction:R-GGA-2730847] Hydrolysis of PIP2 by PLCG [Reaction:R-XTR-2730847] Hydrolysis of PIP2 by PLCG [Reaction:R-SSC-2730847] Hydrolysis of PIP2 by PLCG [Reaction:R-BTA-2730847] Hydrolysis of PIP2 by PLCG [Reaction:R-CFA-2730847] Hydrolysis of PIP2 by PLCG [Reaction:R-RNO-2730847] Hydrolysis of PIP2 by PLCG [Reaction:R-MMU-2730847] Hydrolysis of PIP2 by PLCG [Reaction:R-HSA-2730847] Hydrolysis of PIP2 by PLCG [Reaction:R-GGA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 [Reaction:R-SSC-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 [Reaction:R-BTA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 [Reaction:R-CFA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 [Reaction:R-RNO-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 [Reaction:R-MMU-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 [Reaction:R-HSA-202365] PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 [Reaction:R-DDI-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-CEL-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-DME-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-GGA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-XTR-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-DRE-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-SSC-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-BTA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-CFA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-RNO-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-MMU-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-HSA-437162] PI3K alpha, beta, gamma convert PIP2 to PIP3 [Reaction:R-DDI-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Reaction:R-DME-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Reaction:R-GGA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Reaction:R-XTR-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Reaction:R-SSC-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Reaction:R-BTA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Reaction:R-CFA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Reaction:R-RNO-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Reaction:R-MMU-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Reaction:R-HSA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 [Reaction:R-DME-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-GGA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-DRE-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-SSC-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-BTA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-CFA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-RNO-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-MMU-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-HSA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-DME-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-SSC-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-BTA-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-CFA-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-RNO-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-MMU-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-HSA-2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Reaction:R-GGA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 [Reaction:R-GGA-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate [Reaction:R-SSC-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate [Reaction:R-BTA-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate [Reaction:R-CFA-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate [Reaction:R-RNO-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate [Reaction:R-MMU-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate [Reaction:R-HSA-1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate [Reaction:R-PFA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-SCE-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-SPO-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-DDI-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-CEL-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-DME-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-GGA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-XTR-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-DRE-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-SSC-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-BTA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-CFA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-RNO-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-MMU-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-HSA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-SCE-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Reaction:R-SPO-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Reaction:R-DDI-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Reaction:R-DME-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Reaction:R-GGA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Reaction:R-SSC-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Reaction:R-BTA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Reaction:R-CFA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Reaction:R-RNO-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Reaction:R-MMU-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Reaction:R-HSA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate [Reaction:R-DME-398193] PLC beta-mediated PIP2 hydrolysis [Reaction:R-GGA-398193] PLC beta-mediated PIP2 hydrolysis [Reaction:R-XTR-398193] PLC beta-mediated PIP2 hydrolysis [Reaction:R-SSC-398193] PLC beta-mediated PIP2 hydrolysis [Reaction:R-BTA-398193] PLC beta-mediated PIP2 hydrolysis [Reaction:R-CFA-398193] PLC beta-mediated PIP2 hydrolysis [Reaction:R-MMU-398193] PLC beta-mediated PIP2 hydrolysis [Reaction:R-HSA-398193] PLC beta-mediated PIP2 hydrolysis [Reaction:R-SCE-111879] PIP2 hydrolysis [Reaction:R-SPO-111879] PIP2 hydrolysis [Reaction:R-DDI-111879] PIP2 hydrolysis [Reaction:R-CEL-111879] PIP2 hydrolysis [Reaction:R-DME-111879] PIP2 hydrolysis [Reaction:R-GGA-111879] PIP2 hydrolysis [Reaction:R-XTR-111879] PIP2 hydrolysis [Reaction:R-SSC-111879] PIP2 hydrolysis [Reaction:R-BTA-111879] PIP2 hydrolysis [Reaction:R-CFA-111879] PIP2 hydrolysis [Reaction:R-RNO-111879] PIP2 hydrolysis [Reaction:R-MMU-111879] PIP2 hydrolysis [Reaction:R-HSA-111879] PIP2 hydrolysis [Reaction:R-PFA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-SCE-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-SPO-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-DDI-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-CEL-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-DME-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-GGA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-XTR-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-SSC-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-BTA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-CFA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-RNO-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-MMU-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-RNO-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-198266] PI3K produces PIP3 and other phosphatidyl inositides [Reaction:R-PFA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-SCE-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-SPO-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-DDI-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-DDI-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-CEL-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CEL-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-CEL-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-DME-198266] PI3K produces PIP3 and other phosphatidyl inositides [Reaction:R-DME-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-DME-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DME-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-GGA-198266] PI3K produces PIP3 and other phosphatidyl inositides [Reaction:R-GGA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-GGA-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-GGA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-XTR-198266] PI3K produces PIP3 and other phosphatidyl inositides [Reaction:R-XTR-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-XTR-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-XTR-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-DRE-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-DRE-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-SSC-198266] PI3K produces PIP3 and other phosphatidyl inositides [Reaction:R-SSC-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-SSC-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-MMU-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-HSA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-BTA-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-198266] PI3K produces PIP3 and other phosphatidyl inositides [Reaction:R-BTA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-BTA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-RNO-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-CFA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-CFA-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-MMU-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-198266] PI3K produces PIP3 and other phosphatidyl inositides [Reaction:R-HSA-198266] PI3K produces PIP3 and other phosphatidyl inositides [Reaction:R-RNO-198266] PI3K produces PIP3 and other phosphatidyl inositides [Reaction:R-RNO-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-MMU-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-HSA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-PFA-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-SCE-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-SPO-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-DDI-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-DME-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-GGA-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-XTR-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-DRE-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-SSC-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-BTA-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-CFA-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-RNO-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-MMU-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-PFA-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-SCE-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-SPO-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-DDI-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-DME-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-GGA-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-XTR-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-DRE-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-SSC-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-BTA-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-CFA-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-RNO-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-MMU-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-HSA-202354] Translocation of PLC-gamma1 to PIP2 [Reaction:R-HSA-202407] PLC-gamma1 hydrolyses PIP2 [Reaction:R-RNO-182061] Active Plcg1 hydrolyses PIP2 [Reaction:R-GGA-2029271] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-SSC-2029271] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-BTA-2029271] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-CFA-2029271] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-RNO-2029271] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-MMU-2029271] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-2029271] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-167686] Active PLCG1 hydrolyses PIP2 [Reaction:R-PFA-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-SCE-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-SPO-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 [Reaction:R-HSA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Reaction:R-MMU-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Reaction:R-RNO-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Reaction:R-CFA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Reaction:R-BTA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Reaction:R-SSC-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Reaction:R-DRE-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Reaction:R-XTR-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Reaction:R-GGA-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Reaction:R-DME-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Reaction:R-CEL-177939] PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) [Reaction:R-HSA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane [Reaction:R-HSA-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-MMU-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-RNO-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-CFA-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-BTA-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-SSC-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-XTR-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-GGA-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-DME-114689] PLC gamma 2-mediated PIP2 hydrolysis [Reaction:R-DDI-114689] PLC gamma 2-mediated PIP2 hydrolysis
(output)	[Reaction:R-DME-110459] PIP3 dephosphorylated to PIP2 by DPTEN [Reaction:R-PFA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-SCE-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-SPO-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-DDI-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-CEL-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-DME-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-GGA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-XTR-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-SSC-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-BTA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-CFA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-RNO-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-MMU-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-HSA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 [Reaction:R-CEL-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 [Reaction:R-DME-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 [Reaction:R-GGA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 [Reaction:R-SSC-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 [Reaction:R-BTA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 [Reaction:R-CFA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 [Reaction:R-RNO-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 [Reaction:R-MMU-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 [Reaction:R-HSA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 [Reaction:R-PFA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-PFA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-SCE-199456] PTEN dephosphorylates PIP3 [Reaction:R-SCE-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-SCE-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-SPO-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-SPO-199456] PTEN dephosphorylates PIP3 [Reaction:R-SPO-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-DDI-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-DDI-199456] PTEN dephosphorylates PIP3 [Reaction:R-DDI-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-CEL-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-CEL-199456] PTEN dephosphorylates PIP3 [Reaction:R-CEL-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-DME-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-DME-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-DME-199456] PTEN dephosphorylates PIP3 [Reaction:R-GGA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-GGA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-GGA-199456] PTEN dephosphorylates PIP3 [Reaction:R-XTR-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-XTR-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-XTR-199456] PTEN dephosphorylates PIP3 [Reaction:R-DRE-199456] PTEN dephosphorylates PIP3 [Reaction:R-DRE-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-DRE-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-SSC-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-SSC-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-SSC-199456] PTEN dephosphorylates PIP3 [Reaction:R-BTA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-BTA-199456] PTEN dephosphorylates PIP3 [Reaction:R-BTA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-RNO-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-RNO-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-CFA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-CFA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-CFA-199456] PTEN dephosphorylates PIP3 [Reaction:R-MMU-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-MMU-199456] PTEN dephosphorylates PIP3 [Reaction:R-RNO-199456] PTEN dephosphorylates PIP3 [Reaction:R-MMU-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-HSA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane [Reaction:R-HSA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane [Reaction:R-HSA-199456] PTEN dephosphorylates PIP3
(hasMember)	[DefinedSet:R-ALL-8874460] PI(4,5)P2, PI(3,4,5)P3 [plasma membrane] [DefinedSet:R-ALL-5620974] PI4P,PI(4,5)P2,PIP3 [plasma membrane]
(activeUnit)	[NegativeRegulation:R-HSA-8874423] Negative regulation by 'VAV family:PIP2 [plasma membrane]'

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