Reactome | PI3K phosphorylates PIP2 to PIP3

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PI3K phosphorylates PIP2 to PIP3 Show undefined attributes

authored	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
catalystActivity	[CatalystActivity:2424483] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2424489] Garapati, P V, 2012-07-23
crossReference	[DatabaseIdentifier:12667417] RHEA:21292
dbId	2424480
displayName	PI3K phosphorylates PIP2 to PIP3
edited	[InstanceEdit:2272794] Garapati, P V, 2012-05-25
eventOf	[Pathway:R-HSA-2424491] DAP12 signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-2424481] Recruitment of VAV and BTK to p-SLP-76 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202402] The role of PI3K in immune cells [LiteratureReference:1861717] Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	PI3K phosphorylates PIP2 to PIP3
orthologousEvent	[Reaction:R-MMU-2424480] PI3K phosphorylates PIP2 to PIP3 - Mus musculus [Reaction:R-SSC-2424480] PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-2424480] PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-2424480] PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-2424480] PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2424482] p85 regulatory unit of PI3K binds p-6Y-SYK - Homo sapiens
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2428957] Lanier, Lewis L, 2012-08-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2424480
summation	[Summation:2424321] Activated PI3K phosphorylates phosphatidylinositol (PI) 4-ph...

Referrals

(hasEvent)	[Pathway:R-HSA-2424491] DAP12 signaling
(precedingEvent)	[Reaction:R-HSA-2424481] Recruitment of VAV and BTK to p-SLP-76

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