Reactome | PI3K phosphorylates PIP2 to PIP3

Schema > Reaction > Entries

PI3K phosphorylates PIP2 to PIP3 Show undefined attributes

authored	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
catalystActivity	[CatalystActivity:2029257] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K:p-6Y-SYK [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2029269] Garapati, P V, 2012-01-04
crossReference	[DatabaseIdentifier:12667417] RHEA:21292
dbId	2029271
displayName	PI3K phosphorylates PIP2 to PIP3
edited	[InstanceEdit:2029483] Garapati, P V, 2012-01-04
eventOf	[Pathway:R-HSA-2029485] Role of phospholipids in phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-1861595] Extension of pseudopodia by myosin-X in a PI3K dependent manner - Homo sapiens [Reaction:R-HSA-167686] Active PLCG1 hydrolyses PIP2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1861673] Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis [LiteratureReference:202402] The role of PI3K in immune cells [LiteratureReference:1861728] Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	PI3K phosphorylates PIP2 to PIP3
orthologousEvent	[Reaction:R-GGA-2029271] PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-SSC-2029271] PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-2029271] PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-2029271] PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-2029271] PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-2029271] PI3K phosphorylates PIP2 to PIP3 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2029273] PI3K binds to p-6Y-SYK - Homo sapiens
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248842] Rosales, C, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2029271
summation	[Summation:1861678] Activated PI3K phosphorylates phosphatidylinositol (PI) 4-ph...

Referrals

(precedingEvent)	[Reaction:R-HSA-1861595] Extension of pseudopodia by myosin-X in a PI3K dependent manner [Reaction:R-HSA-167686] Active PLCG1 hydrolyses PIP2
(hasEvent)	[Pathway:R-HSA-2029485] Role of phospholipids in phagocytosis