Reactome | PtdIns(4,5)P2 binds WASP, N-WASP

Schema > Reaction > Entries

authored	[InstanceEdit:9670158] Murillo, Julieth, 2019-12-05
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9670158] Murillo, Julieth, 2019-12-05
dbId	9670156
displayName	PtdIns(4,5)P2 binds WASP, N-WASP
edited	[InstanceEdit:9675774] Murillo, Julieth, 2020-02-05
eventOf	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis - Homo sapiens
followingEvent	[Reaction:R-HSA-9670155] CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP - Homo sapiens
inferredFrom	[Reaction:R-HSA-442586] Activation of WASP and N-WASP by CDC42 - Homo sapiens
input	[SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane] [DefinedSet:R-HSA-201892] WASP/N-WASP [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2028873] A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PtdIns(4,5)P2 binds WASP, N-WASP
output	[Complex:R-HSA-9667225] PI(4,5)P2:WASP/N-WASP [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-2029445] An unknown GEF exchanges GTP for GDP on CDC42:GDP - Homo sapiens
releaseDate	2020-03-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9675734] Gregory, David J, 2020-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9670156
summation	[Summation:442581] Wiskott-Aldrich syndrome protein (WASP) and Neural-WASP (N-W...

(hasEvent)	[Pathway:R-HSA-9664422] FCGR3A-mediated phagocytosis
(precedingEvent)	[Reaction:R-HSA-9670155] CDC42:GTP binds PtdIns(4,5)P2:WASP,N-WASP
(inferredTo)	[Reaction:R-HSA-442586] Activation of WASP and N-WASP by CDC42

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