Reactome | EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]

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EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10422526] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-BTA-8867041] EGFR phosphorylates EPS15 - Bos taurus
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10422523
displayName	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]
hasComponent	[Complex:R-BTA-182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] [EntityWithAccessionedSequence:R-BTA-182952] EPN1 [plasma membrane] [Complex:R-BTA-182947] EPS15:HGS:STAM [cytosol] [EntityWithAccessionedSequence:R-BTA-182937] EPS15L1 [plasma membrane] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] - Homo sapiens
maxDepth	6
name	EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM
producedByEvent	[Reaction:R-BTA-8867047] PTPN3 dephosphorylates EPS15 - Bos taurus [Reaction:R-BTA-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Bos taurus
schemaClass	Complex
species	[Species:48898] Bos taurus
stId	R-BTA-8867034
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-BTA-8867047] PTPN3 dephosphorylates EPS15 [Reaction:R-BTA-8867044] EGFR binds EPS15, EPN1, EPS15L1
(input)	[Reaction:R-BTA-8867041] EGFR phosphorylates EPS15
(physicalEntity)	[CatalystActivity:10422526] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]
(inferredTo)	[Complex:R-HSA-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]

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