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Schema
>
BlackBoxEvent
>
Entries
PI3K produces PIP3 and other phosphatidyl inositides
Show undefined attributes
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authored
[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity
[CatalystActivity:198361] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane]
category
uncertain
compartment
[Compartment:947587] cytoplasmic side of plasma membrane
created
[InstanceEdit:198310] 2007-07-10 08:01:55
crossReference
[DatabaseIdentifier:12667417] RHEA:21292
dbId
198266
displayName
PI3K produces PIP3 and other phosphatidyl inositides
edited
[InstanceEdit:9865828] Orlic-Milacic, Marija, 2024-03-19
eventOf
[Pathway:R-HSA-198203] PI3K/AKT activation - Homo sapiens
followingEvent
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling - Homo sapiens
[Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens
[Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane - Homo sapiens
[Reaction:R-HSA-199456] PTEN dephosphorylates PIP3 - Homo sapiens
[Reaction:R-HSA-202692] PIP3 binds to RhoA and activates it - Homo sapiens
[Reaction:R-HSA-9603279] PIP3 recruits PDK1 and AKT to the membrane - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:198308] IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
PI3K produces PIP3 and other phosphatidyl inositides
orthologousEvent
[BlackBoxEvent:R-MMU-198266] PI3K produces PIP3 and other phosphatidyl inositides - Mus musculus
[BlackBoxEvent:R-GGA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Gallus gallus
[BlackBoxEvent:R-XTR-198266] PI3K produces PIP3 and other phosphatidyl inositides - Xenopus tropicalis
[BlackBoxEvent:R-DRE-198266] PI3K produces PIP3 and other phosphatidyl inositides - Danio rerio
[BlackBoxEvent:R-SSC-198266] PI3K produces PIP3 and other phosphatidyl inositides - Sus scrofa
[BlackBoxEvent:R-BTA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Bos taurus
[BlackBoxEvent:R-CFA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Canis familiaris
[BlackBoxEvent:R-RNO-198266] PI3K produces PIP3 and other phosphatidyl inositides - Rattus norvegicus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent
[Reaction:R-HSA-198315] Active IRS recruits PI3K to the plasma membrane and activates it - Homo sapiens
releaseDate
2008-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
[InstanceEdit:9865830] Matthews, Lisa, 2024-03-19
[InstanceEdit:9865829] D'Eustachio, Peter, 2024-03-19
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-198266
summation
[Summation:198351] In line with activation of PI3-kinase (PI3K) by other recept...
updateTrackers
[UpdateTracker:9791298] Update Tracker - [Reaction:198266] PI3K produces PIP3 and other phosphatidyl inositides - v31:[modifyText]
[UpdateTracker:9911014] Update Tracker - [BlackBoxEvent:198266] PI3K produces PIP3 and other phosphatidyl inositides - v89:[add_removeLiteratureReference, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9791298] Update Tracker - [Reaction:198266] PI3K produces PIP3 and other phosphatidyl inositides - v31:[modifyText]
[UpdateTracker:9911014] Update Tracker - [BlackBoxEvent:198266] PI3K produces PIP3 and other phosphatidyl inositides - v89:[add_removeLiteratureReference, modifyText]
(precedingEvent)
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
[Reaction:R-HSA-9603279] PIP3 recruits PDK1 and AKT to the membrane
[Reaction:R-HSA-202692] PIP3 binds to RhoA and activates it
[Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane
[Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane
[Reaction:R-HSA-199456] PTEN dephosphorylates PIP3
(hasEvent)
[Pathway:R-HSA-198203] PI3K/AKT activation
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