Reactome | PI3K produces PIP3 and other phosphatidyl inositides

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PI3K produces PIP3 and other phosphatidyl inositides Show undefined attributes

catalystActivity	[CatalystActivity:10221094] phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane]
category	transition
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
dbId	10221096
displayName	PI3K produces PIP3 and other phosphatidyl inositides
eventOf	[Pathway:R-BTA-198203] PI3K/AKT activation - Bos taurus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Pathway:R-BTA-1257604] PIP3 activates AKT signaling - Bos taurus [Reaction:R-BTA-2316429] PIP3 recruits PDPK1 to the membrane - Bos taurus [Reaction:R-BTA-199456] PTEN dephosphorylates PIP3 - Bos taurus [Reaction:R-BTA-202692] PIP3 binds to RhoA and activates it - Bos taurus
inferredFrom	[Reaction:R-HSA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
name	PI3K produces PIP3 and other phosphatidyl inositides
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-BTA-199456] PTEN dephosphorylates PIP3 - Bos taurus [Reaction:R-BTA-198315] Active IRS recruits PI3K to the plasma membrane and activates it - Bos taurus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-198266
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Pathway:R-BTA-1257604] PIP3 activates AKT signaling [Reaction:R-BTA-202692] PIP3 binds to RhoA and activates it [Reaction:R-BTA-2316429] PIP3 recruits PDPK1 to the membrane [Reaction:R-BTA-199456] PTEN dephosphorylates PIP3
(hasEvent)	[Pathway:R-BTA-198203] PI3K/AKT activation
(inferredTo)	[Reaction:R-HSA-198266] PI3K produces PIP3 and other phosphatidyl inositides