Reactome | Hydrolysis of PIP2 by PLCG

Schema > Reaction > Entries

Hydrolysis of PIP2 by PLCG Show undefined attributes

catalystActivity	[CatalystActivity:10390399] phosphatidylinositol-4,5-bisphosphate phospholipase C activity of p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10390401
displayName	Hydrolysis of PIP2 by PLCG
eventOf	[Pathway:R-BTA-2871809] FCERI mediated Ca+2 mobilization - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-202328] Translocation of PKC theta to plasma membrane - Bos taurus
inferredFrom	[Reaction:R-HSA-2730847] Hydrolysis of PIP2 by PLCG - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Hydrolysis of PIP2 by PLCG
output	[SimpleEntity:R-ALL-112275] DAGs [plasma membrane] [SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-2730847
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2871809] FCERI mediated Ca+2 mobilization
(precedingEvent)	[Reaction:R-BTA-202328] Translocation of PKC theta to plasma membrane
(inferredTo)	[Reaction:R-HSA-2730847] Hydrolysis of PIP2 by PLCG