Reactome | PLC-gamma1 hydrolyses PIP2

Schema > Reaction > Entries

PLC-gamma1 hydrolyses PIP2 Show undefined attributes

catalystActivity	[CatalystActivity:10665982] phosphatidylinositol-4,5-bisphosphate phospholipase C activity of p-PLCG [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10665984
displayName	PLC-gamma1 hydrolyses PIP2
eventOf	[Pathway:R-XTR-202433] Generation of second messenger molecules - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-202407] PLC-gamma1 hydrolyses PIP2 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PLC-gamma1 hydrolyses PIP2
output	[SimpleEntity:R-ALL-112275] DAGs [plasma membrane] [SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
precedingEvent	[Reaction:R-XTR-202354] Translocation of PLC-gamma1 to PIP2 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-202407
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-202433] Generation of second messenger molecules
(inferredTo)	[Reaction:R-HSA-202407] PLC-gamma1 hydrolyses PIP2