Reactome | PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

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PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 Show undefined attributes

catalystActivity	[CatalystActivity:11073109] 1-phosphatidylinositol-4-phosphate 5-kinase activity of PIP5K1C [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
dbId	11073111
displayName	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2
eventOf	[Pathway:R-SPO-8856828] Clathrin-mediated endocytosis - Schizosaccharomyces pombe
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-392417] PI4P [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PIP5K1C phosphorylates PI(4)P to PI(4,5)P2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68324] Schizosaccharomyces pombe
stId	R-SPO-8868066
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SPO-8856828] Clathrin-mediated endocytosis
(inferredTo)	[Reaction:R-HSA-8868066] PIP5K1C phosphorylates PI(4)P to PI(4,5)P2

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