Reactome | G beta:gamma activated PI3Kgamma converts PIP2 to PIP3

Schema > Reaction > Entries

G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 Show undefined attributes

authored	[InstanceEdit:392294] Jupe, S, 2009-03-02 16:22:24
catalystActivity	[CatalystActivity:392298] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of G-protein beta-gamma:PI3K gamma [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:392299] Jupe, S, 2009-03-02 16:48:56
crossReference	[DatabaseIdentifier:12667417] RHEA:21292
dbId	392300
displayName	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
edited	[InstanceEdit:435389] Jupe, S, 2009-09-09
eventOf	[Pathway:R-HSA-392451] G beta:gamma signalling through PI3Kgamma - Homo sapiens
followingEvent	[Reaction:R-HSA-202692] PIP3 binds to RhoA and activates it - Homo sapiens [Reaction:R-HSA-9603279] PIP3 recruits PDK1 and AKT to the membrane - Homo sapiens [Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens [Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:425636] Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
orthologousEvent	[Reaction:R-DDI-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Dictyostelium discoideum [Reaction:R-CEL-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Caenorhabditis elegans [Reaction:R-GGA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-SSC-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-392300] G beta:gamma activated PI3Kgamma converts PIP2 to PIP3 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-392295] Gbeta:gamma recruits PI3K gamma - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:425201] Akkerman, JW, 2009-06-03
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-392300
summation	[Summation:425633] Biochemical and cellular studies have shown that the p101/p1...

Referrals

(precedingEvent)	[Reaction:R-HSA-9603279] PIP3 recruits PDK1 and AKT to the membrane [Reaction:R-HSA-202692] PIP3 binds to RhoA and activates it [Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane [Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane
(hasEvent)	[Pathway:R-HSA-392451] G beta:gamma signalling through PI3Kgamma