Reactome | BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

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BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 Show undefined attributes

catalystActivity	[CatalystActivity:10149786] 1-phosphatidylinositol-3-kinase activity of BCAP Signalosome [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10098795] Wright, Adam, 2024-03-07
dbId	10149788
displayName	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
eventOf	[Pathway:R-CFA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Canis familiaris
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated - Canis familiaris [Reaction:R-CFA-2316429] PIP3 recruits PDPK1 to the membrane - Canis familiaris
inferredFrom	[Reaction:R-HSA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Homo sapiens
input	[SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
name	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
output	[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2045911
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
(precedingEvent)	[BlackBoxEvent:R-CFA-9606884] PI(3,4,5)P3 (PIP3) binds DAPP1 (BAM32) and DAPP1 is phosphorylated [Reaction:R-CFA-2316429] PIP3 recruits PDPK1 to the membrane
(inferredTo)	[Reaction:R-HSA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3