Reactome | PI3K phosphorylates PIP2 to PIP3

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PI3K phosphorylates PIP2 to PIP3 Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity	[CatalystActivity:2316433] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activator:PI3K [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2316430] Orlic-Milacic, M, 2012-06-09
crossReference	[DatabaseIdentifier:12667417] RHEA:21292
dbId	2316434
diseaseReaction	[Reaction:R-HSA-2394007] PI3K gain of function mutants phosphorylate PIP2 to PIP3 - Homo sapiens
displayName	PI3K phosphorylates PIP2 to PIP3
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
eventOf	[Pathway:R-HSA-1257604] PIP3 activates AKT signaling - Homo sapiens [Pathway:R-HSA-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-199456] PTEN dephosphorylates PIP3 - Homo sapiens [Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens [Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:262292] positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2327862] A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane [LiteratureReference:2327861] Dynamics of the phosphoinositide 3-kinase p110? interaction with p85? and membranes reveals aspects of regulation distinct from p110?
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PI3K phosphorylates PIP2 to PIP3
orthologousEvent	[Reaction:R-BTA-2316434] PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-SSC-2316434] PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-DRE-2316434] PI3K phosphorylates PIP2 to PIP3 - Danio rerio [Reaction:R-XTR-2316434] PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-GGA-2316434] PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-DME-2316434] PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-CEL-2316434] PI3K phosphorylates PIP2 to PIP3 - Caenorhabditis elegans [Reaction:R-CFA-2316434] PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-2316434] PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-2316434] PI3K phosphorylates PIP2 to PIP3 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Homo sapiens [Reaction:R-HSA-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Homo sapiens [Reaction:R-HSA-177927] PI3K binds to EGF:EGFR:GRB2:GAB1 - Homo sapiens [Reaction:R-HSA-1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer - Homo sapiens [Reaction:R-HSA-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR - Homo sapiens [Reaction:R-HSA-1250346] Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers - Homo sapiens [Reaction:R-HSA-5654591] Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654614] Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654622] Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654640] Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654643] Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654662] Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA - Homo sapiens [Reaction:R-HSA-5654669] Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA - Homo sapiens [Reaction:R-HSA-186780] PI3-kinase binds to the active receptor - Homo sapiens [Reaction:R-HSA-198315] Active IRS recruits PI3K to the plasma membrane and activates it - Homo sapiens [Reaction:R-HSA-205262] Direct recruitment of PI3K to p-KIT - Homo sapiens [Reaction:R-HSA-388830] PI3K binds ICOS - Homo sapiens [Reaction:R-HSA-202203] Recruitment of PI3K to plasma membrane - Homo sapiens [Reaction:R-HSA-1250353] Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers - Homo sapiens [Reaction:R-HSA-114542] RAC1,RAC2,RHOG activate PI3K - Homo sapiens [BlackBoxEvent:R-HSA-9028505] Activated NTRK2 recruits PI3K - Homo sapiens [Reaction:R-HSA-9603407] Activated NTRK3 binds PI3K - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-8981988] Positive regulation by 'IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane]'
regulationReference	[RegulationReference:9643032] Positive regulation by 'IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane]' IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13 [InstanceEdit:8856765] Porteu, Fran�oise, 2016-02-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2316434
summation	[Summation:2316435] A number of different extracellular signals converge on PI3K...
updateTrackers	[UpdateTracker:9780918] Update Tracker - [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 - v61:[addRegulator]

Referrals

(precedingEvent)	[Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane [Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane [Reaction:R-HSA-199456] PTEN dephosphorylates PIP3
(hasEvent)	[Pathway:R-HSA-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(normalReaction)	[Reaction:R-HSA-2394007] PI3K gain of function mutants phosphorylate PIP2 to PIP3
(updatedInstance)	[UpdateTracker:9780918] Update Tracker - [Reaction:2316434] PI3K phosphorylates PIP2 to PIP3 - v61:[addRegulator]

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