Reactome | CDC42 and PIP2 bind WASL, activating it

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CDC42 and PIP2 bind WASL, activating it Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10172228
displayName	CDC42 and PIP2 bind WASL, activating it
eventOf	[Pathway:R-RNO-3928662] EPHB-mediated forward signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-3928595] N-WASP binds ARP2/3 and G-actin - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-3928601] CDC42 and PIP2 bind WASL, activating it - Homo sapiens
input	[Complex:R-RNO-3928566] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	CDC42 and PIP2 bind WASL, activating it
output	[Complex:R-RNO-3928536] p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3928601
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3928662] EPHB-mediated forward signaling
(precedingEvent)	[Reaction:R-RNO-3928595] N-WASP binds ARP2/3 and G-actin
(inferredTo)	[Reaction:R-HSA-3928601] CDC42 and PIP2 bind WASL, activating it

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