Reactome | PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]

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PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-DME-8866265] ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] - Drosophila melanogaster
consumedByEvent	[Reaction:R-DME-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit - Drosophila melanogaster [Reaction:R-DME-8866283] ARBB recruits GPCRs into clathrin-coated pits - Drosophila melanogaster
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10894790
displayName	PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]
hasComponent	2 × [Complex:R-DME-350827] Clathrin Triskelion [cytosol] [EntityWithAccessionedSequence:R-DME-3006481] Dap160 [cytosol] [EntityWithAccessionedSequence:R-DME-182920] Eps-15 [cytosol] [DefinedSet:R-DME-8862270] FCHO1,2 dimer [cytosol] [GenomeEncodedEntity:R-DME-8854795] Ghost homologue of AAK1 [cytosol] [GenomeEncodedEntity:R-DME-8862268] Ghost homologue of SGIP1 [cytosol] [CandidateSet:R-DME-8863469] NECAPs [cytosol] 3 × [Complex:R-DME-8856815] p-T156 AP-2 Complex [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane] [EntityWithAccessionedSequence:R-DME-8862265] Reps [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] - Homo sapiens
maxDepth	4
name	PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1
producedByEvent	[Reaction:R-DME-8856813] AAK1 phosphorylates AP-2 mu subunit at T156 - Drosophila melanogaster
schemaClass	Complex
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8856806
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-DME-8867756] CLASP proteins and cargo are recruited to the nascent clathrin-coated pit [Reaction:R-DME-8866283] ARBB recruits GPCRs into clathrin-coated pits
(hasComponent)	[Complex:R-DME-8866265] ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] [Complex:R-DME-8867753] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane]
(output)	[Reaction:R-DME-8856813] AAK1 phosphorylates AP-2 mu subunit at T156
(inferredTo)	[Complex:R-HSA-8856806] PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane]

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