Reactome | EGFR binds EPS15, EPN1, EPS15L1

Schema > Reaction > Entries

EGFR binds EPS15, EPN1, EPS15L1 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10422530
displayName	EGFR binds EPS15, EPN1, EPS15L1
eventOf	[Pathway:R-BTA-182971] EGFR downregulation - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-8867041] EGFR phosphorylates EPS15 - Bos taurus
inferredFrom	[Reaction:R-HSA-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Homo sapiens
input	[Complex:R-BTA-182946] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] [EntityWithAccessionedSequence:R-BTA-182952] EPN1 [plasma membrane] [Complex:R-BTA-182947] EPS15:HGS:STAM [cytosol] [EntityWithAccessionedSequence:R-BTA-182937] EPS15L1 [plasma membrane] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	EGFR binds EPS15, EPN1, EPS15L1
output	[Complex:R-BTA-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]
precedingEvent	[Reaction:R-BTA-182994] Assembly of EGFR complex in clathrin-coated vesicles - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8867044
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-182971] EGFR downregulation
(precedingEvent)	[Reaction:R-BTA-8867041] EGFR phosphorylates EPS15
(inferredTo)	[Reaction:R-HSA-8867044] EGFR binds EPS15, EPN1, EPS15L1