Reactome | CD28 bound PI3K phosphorylates PIP2 to PIP3

Schema > Reaction > Entries

CD28 bound PI3K phosphorylates PIP2 to PIP3 Show undefined attributes

authored	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
catalystActivity	[CatalystActivity:389160] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of CD28:PI3K [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:389155] Garapati, P V, 2008-12-22 11:20:58
crossReference	[DatabaseIdentifier:12667417] RHEA:21292
dbId	389158
displayName	CD28 bound PI3K phosphorylates PIP2 to PIP3
edited	[InstanceEdit:388810] Garapati, P V, 2008-12-16 11:12:19
eventOf	[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-202164] Translocation of PDK1 to Plasma membrane - Homo sapiens [Reaction:R-HSA-389352] Translocation of Vav1 to CD28 - Homo sapiens [Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane - Homo sapiens [Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane - Homo sapiens [Reaction:R-HSA-9603279] PIP3 recruits PDK1 and AKT to the membrane - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202402] The role of PI3K in immune cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CD28 bound PI3K phosphorylates PIP2 to PIP3
orthologousEvent	[Reaction:R-GGA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-DRE-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Danio rerio [Reaction:R-SSC-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-BTA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-388832] PI3K binds CD28 - Homo sapiens
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422514] Bluestone, JA, Esensten, J, 2009-06-01 18:47:33
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-389158
summation	[Summation:389373] Upon binding to CD28, the PI3K enzyme catalyzes the phosphor...
updateTrackers	[UpdateTracker:9928522] Update Tracker - [Reaction:389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - v91:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9928522] Update Tracker - [Reaction:389158] CD28 bound PI3K phosphorylates PIP2 to PIP3 - v91:[modifyText]
(precedingEvent)	[Reaction:R-HSA-9603279] PIP3 recruits PDK1 and AKT to the membrane [Reaction:R-HSA-202164] Translocation of PDK1 to Plasma membrane [Reaction:R-HSA-389352] Translocation of Vav1 to CD28 [Reaction:R-HSA-2316429] PIP3 recruits PDPK1 to the membrane [Reaction:R-HSA-2317332] PIP3 recruits AKT to the membrane
(hasEvent)	[Pathway:R-HSA-389357] CD28 dependent PI3K/Akt signaling