Reactome | p-Y753,Y759-PLCG2 hydrolyses PIP2

Schema > Reaction > Entries

p-Y753,Y759-PLCG2 hydrolyses PIP2 Show undefined attributes

authored	[InstanceEdit:5607752] Garapati, P V, 2014-07-14
catalystActivity	[CatalystActivity:5607715] phosphatidylinositol-4,5-bisphosphate phospholipase C activity of p-Y753,Y759-PLCG2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5607752] Garapati, P V, 2014-07-14
dbId	5607735
displayName	p-Y753,Y759-PLCG2 hydrolyses PIP2
edited	[InstanceEdit:5607752] Garapati, P V, 2014-07-14
eventOf	[Pathway:R-HSA-5607764] CLEC7A (Dectin-1) signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-5607734] PKC-delta translocates to plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5607318] Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	p-Y753,Y759-PLCG2 hydrolyses PIP2
orthologousEvent	[Reaction:R-PFA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Plasmodium falciparum [Reaction:R-SCE-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Saccharomyces cerevisiae [Reaction:R-SPO-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Schizosaccharomyces pombe [Reaction:R-DDI-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Dictyostelium discoideum [Reaction:R-CEL-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Caenorhabditis elegans [Reaction:R-DME-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Drosophila melanogaster [Reaction:R-GGA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Gallus gallus [Reaction:R-XTR-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Xenopus tropicalis [Reaction:R-SSC-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Sus scrofa [Reaction:R-BTA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Bos taurus [Reaction:R-CFA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Canis familiaris [Reaction:R-RNO-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Rattus norvegicus [Reaction:R-MMU-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Mus musculus
output	[SimpleEntity:R-ALL-112275] DAGs [plasma membrane] [SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
precedingEvent	[Reaction:R-HSA-5607755] p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane - Homo sapiens
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5621625] Geijtenbeek, Teunis B H, 2014-09-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5607735
summation	[Summation:5607587] Following tyrosine phosphorylation, phospholipase C-gamma 2 ...

Referrals

(hasEvent)	[Pathway:R-HSA-5607764] CLEC7A (Dectin-1) signaling
(precedingEvent)	[Reaction:R-HSA-5607734] PKC-delta translocates to plasma membrane