Reactome | Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate

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Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate Show undefined attributes

catalystActivity	[CatalystActivity:11010008] C-type glycerophospholipase activity of PLC beta1,2,3:G-alpha(q):GTP [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
dbId	11010010
displayName	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
eventOf	[Pathway:R-DDI-399997] Acetylcholine regulates insulin secretion - Dictyostelium discoideum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DDI-400015] Diacylgycerol activates Protein kinase C, alpha type - Dictyostelium discoideum
inferredFrom	[Reaction:R-HSA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)
output	[SimpleEntity:R-ALL-114519] DAG [plasma membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170941] Dictyostelium discoideum
stId	R-DDI-399998
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DDI-399997] Acetylcholine regulates insulin secretion [Pathway:R-DDI-434316] Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
(precedingEvent)	[Reaction:R-DDI-400015] Diacylgycerol activates Protein kinase C, alpha type
(inferredTo)	[Reaction:R-HSA-399998] Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate

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