Reactome | p-Y753,Y759-PLCG2 hydrolyses PIP2

Schema > Reaction > Entries

p-Y753,Y759-PLCG2 hydrolyses PIP2 Show undefined attributes

catalystActivity	[CatalystActivity:10055598] phosphatidylinositol phospholipase C activity of p-Y753,Y759-PLCG2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10055600
displayName	p-Y753,Y759-PLCG2 hydrolyses PIP2
eventOf	[Pathway:R-RNO-5607764] CLEC7A (Dectin-1) signaling - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5607734] PKC-delta translocates to plasma membrane - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
name	p-Y753,Y759-PLCG2 hydrolyses PIP2
output	[SimpleEntity:R-ALL-112275] DAGs [plasma membrane] [SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
precedingEvent	[Reaction:R-RNO-5607755] p-Y753,Y759-PLCG2 translocates from cytosol to plasma membrane - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5607735
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5607764] CLEC7A (Dectin-1) signaling
(precedingEvent)	[Reaction:R-RNO-5607734] PKC-delta translocates to plasma membrane
(inferredTo)	[Reaction:R-HSA-5607735] p-Y753,Y759-PLCG2 hydrolyses PIP2