Reactome | FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3

Schema > Reaction > Entries

FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 Show undefined attributes

authored	[InstanceEdit:1489508] Rothfels, K, 2011-08-15
catalystActivity	[CatalystActivity:5654686] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5654691] Rothfels, Karen, 2014-12-03
crossReference	[DatabaseIdentifier:12667417] RHEA:21292
dbId	5654692
deleted	[Deleted:5655533] Deletion of instance: 1272493
displayName	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
eventOf	[Pathway:R-HSA-5654689] PI-3K cascade:FGFR1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191045] Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins [LiteratureReference:190609] Cellular signaling by fibroblast growth factor receptors
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
orthologousEvent	[Reaction:R-SSC-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Sus scrofa [Reaction:R-DME-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Drosophila melanogaster [Reaction:R-GGA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Gallus gallus [Reaction:R-XTR-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Xenopus tropicalis [Reaction:R-DRE-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Danio rerio [Reaction:R-BTA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Bos taurus [Reaction:R-CFA-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Canis familiaris [Reaction:R-RNO-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Rattus norvegicus [Reaction:R-MMU-5654692] FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5654596] Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
releaseDate	2011-09-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1549563] Gotoh, N, 2011-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5654692
summation	[Summation:1384553] Once recruited to the activated receptor, PI3K phosphorylate...

Referrals

(replacementInstances)	[Deleted:5655533] Deletion of instance: 1272493
(hasEvent)	[Pathway:R-HSA-5654689] PI-3K cascade:FGFR1