Reactome | PI3K synthesizes PIP3 downstream of ALK

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PI3K synthesizes PIP3 downstream of ALK Show undefined attributes

catalystActivity	[CatalystActivity:10669703] phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Active ALK:PI3K [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10669705
displayName	PI3K synthesizes PIP3 downstream of ALK
eventOf	[Pathway:R-DME-201556] Signaling by ALK - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-201510] PI3K synthesizes PIP3 downstream of ALK - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
name	PI3K synthesizes PIP3 downstream of ALK
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-201510
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-201556] Signaling by ALK
(inferredTo)	[Reaction:R-HSA-201510] PI3K synthesizes PIP3 downstream of ALK

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