Reactome | BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

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BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 Show undefined attributes

catalystActivity	[CatalystActivity:10869106] 1-phosphatidylinositol-3-kinase activity of BCAP Signalosome [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10869108
displayName	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
eventOf	[Pathway:R-DME-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-9603279] PIP3 recruits PDK1 and AKT to the membrane - Drosophila melanogaster [Reaction:R-DME-2316429] PIP3 recruits PDPK1 to the membrane - Drosophila melanogaster [Reaction:R-DME-2317332] PIP3 recruits AKT to the membrane - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 - Homo sapiens
input	[SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
output	[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-2045911
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-DME-9603279] PIP3 recruits PDK1 and AKT to the membrane [Reaction:R-DME-2316429] PIP3 recruits PDPK1 to the membrane [Reaction:R-DME-2317332] PIP3 recruits AKT to the membrane
(hasEvent)	[Pathway:R-DME-983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
(inferredTo)	[Reaction:R-HSA-2045911] BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3

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