Reactome | MET bound PI3K generates PIP3

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MET bound PI3K generates PIP3 Show undefined attributes

authored	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
catalystActivity	[CatalystActivity:8852032] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8852018] Orlic-Milacic, Marija, 2016-01-12
crossReference	[DatabaseIdentifier:12667417] RHEA:21292
dbId	8852019
displayName	MET bound PI3K generates PIP3
edited	[InstanceEdit:8876386] Orlic-Milacic, Marija, 2016-06-14
eventOf	[Pathway:R-HSA-8851907] MET activates PI3K/AKT signaling - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8851912] Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses [LiteratureReference:179899] A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	MET bound PI3K generates PIP3
orthologousEvent	[Reaction:R-GGA-8852019] MET bound PI3K generates PIP3 - Gallus gallus [Reaction:R-XTR-8852019] MET bound PI3K generates PIP3 - Xenopus tropicalis [Reaction:R-DRE-8852019] MET bound PI3K generates PIP3 - Danio rerio [Reaction:R-SSC-8852019] MET bound PI3K generates PIP3 - Sus scrofa [Reaction:R-BTA-8852019] MET bound PI3K generates PIP3 - Bos taurus [Reaction:R-CFA-8852019] MET bound PI3K generates PIP3 - Canis familiaris [Reaction:R-RNO-8852019] MET bound PI3K generates PIP3 - Rattus norvegicus [Reaction:R-MMU-8852019] MET bound PI3K generates PIP3 - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8851954] Phosphorylated GAB1 recruits PI3K to MET - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8931695] Heynen, Guustaaf, 2016-07-11 [InstanceEdit:8931697] Birchmeier, Walter, 2016-07-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8852019
summation	[Summation:8852037] Phosphatidylinositol-4,5-bisphosphate 3-kinase, PI3K, recrui...

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[Pathway:R-HSA-8851907] MET activates PI3K/AKT signaling