Reactome | PLC gamma 2-mediated PIP2 hydrolysis

Schema > Reaction > Entries

PLC gamma 2-mediated PIP2 hydrolysis Show undefined attributes

catalystActivity	[CatalystActivity:11084574] C-type glycerophospholipase activity of p-PLCG2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
dbId	11084576
displayName	PLC gamma 2-mediated PIP2 hydrolysis
eventOf	[Pathway:R-SCE-114604] GPVI-mediated activation cascade - Saccharomyces cerevisiae
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SCE-114553] Activation of conventional Protein Kinase C - Saccharomyces cerevisiae [Reaction:R-SCE-425861] Activation of Protein Kinase C novel isoforms - Saccharomyces cerevisiae
inferredFrom	[Reaction:R-HSA-114689] PLC gamma 2-mediated PIP2 hydrolysis - Homo sapiens
input	[SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PLC gamma 2-mediated PIP2 hydrolysis
output	[SimpleEntity:R-ALL-114519] DAG [plasma membrane] [SimpleEntity:R-ALL-114520] I(1,4,5)P3 [cytosol]
precedingEvent	[BlackBoxEvent:R-SCE-429497] SLP-76 stimulates PLC gamma 2 - Saccharomyces cerevisiae
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68322] Saccharomyces cerevisiae
stId	R-SCE-114689
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SCE-114604] GPVI-mediated activation cascade
(precedingEvent)	[Reaction:R-SCE-114553] Activation of conventional Protein Kinase C [Reaction:R-SCE-425861] Activation of Protein Kinase C novel isoforms
(inferredTo)	[Reaction:R-HSA-114689] PLC gamma 2-mediated PIP2 hydrolysis