Reactome | PI3K catalyses the phosphorylation of PIP2 to PIP3

Schema > Reaction > Entries

PI3K catalyses the phosphorylation of PIP2 to PIP3 Show undefined attributes

catalystActivity	[CatalystActivity:10000199] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10000201
displayName	PI3K catalyses the phosphorylation of PIP2 to PIP3
eventOf	[Pathway:R-MMU-186763] Downstream signal transduction - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI3K catalyses the phosphorylation of PIP2 to PIP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-MMU-186780] PI3-kinase binds to the active receptor - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-186800
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-186763] Downstream signal transduction
(inferredTo)	[Reaction:R-HSA-186800] PI3K catalyses the phosphorylation of PIP2 to PIP3

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