Reactome | PI3K phosphorylates PIP2 to PIP3

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PI3K phosphorylates PIP2 to PIP3 Show undefined attributes

catalystActivity	[CatalystActivity:10870864] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activator:PI3K [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10870866
displayName	PI3K phosphorylates PIP2 to PIP3
eventOf	[Pathway:R-DME-1257604] PIP3 activates AKT signaling - Drosophila melanogaster [Pathway:R-DME-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-199456] PTEN dephosphorylates PIP3 - Drosophila melanogaster [Reaction:R-DME-2316429] PIP3 recruits PDPK1 to the membrane - Drosophila melanogaster [Reaction:R-DME-2317332] PIP3 recruits AKT to the membrane - Drosophila melanogaster
goBiologicalProcess	[GO_BiologicalProcess:262292] positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferredFrom	[Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI3K phosphorylates PIP2 to PIP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-DME-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Drosophila melanogaster [Reaction:R-DME-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Drosophila melanogaster [Reaction:R-DME-186780] PI3-kinase binds to the active receptor - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-2316434
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1257604] PIP3 activates AKT signaling [Pathway:R-DME-6811558] PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
(precedingEvent)	[Reaction:R-DME-2316429] PIP3 recruits PDPK1 to the membrane [Reaction:R-DME-2317332] PIP3 recruits AKT to the membrane [Reaction:R-DME-199456] PTEN dephosphorylates PIP3
(inferredTo)	[Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3