Reactome | PI3K gain of function mutants phosphorylate PIP2 to PIP3

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PI3K gain of function mutants phosphorylate PIP2 to PIP3 Show undefined attributes

authored	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
catalystActivity	[CatalystActivity:2394010] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K mutants [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:2394009] Orlic-Milacic, M, 2012-06-28
crossReference	[DatabaseIdentifier:12667417] RHEA:21292 [DatabaseIdentifier:12020745] Mondo:0004992
dbId	2394007
disease	[Disease:1500689] cancer
displayName	PI3K gain of function mutants phosphorylate PIP2 to PIP3
edited	[InstanceEdit:2426555] Matthews, L, 2012-08-03
entityFunctionalStatus	[EntityFunctionalStatus:2632525] gain_of_function of PI3K mutants [plasma membrane]
eventOf	[Pathway:R-HSA-2219530] Constitutive Signaling by Aberrant PI3K in Cancer - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2327862] A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane [LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations [LiteratureReference:2399575] The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells [LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit [LiteratureReference:2399617] Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells [LiteratureReference:2399642] Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases [LiteratureReference:2399685] Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha [LiteratureReference:2399688] Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation [LiteratureReference:2399690] PIK3R1 (p85?) is somatically mutated at high frequency in primary endometrial cancer [LiteratureReference:2404155] High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability [LiteratureReference:2399870] Targeting the phosphoinositide 3-kinase pathway in cancer [LiteratureReference:2460050] PTEN restoration and PIK3CB knockdown synergistically suppress glioblastoma growth in vitro and in xenografts [LiteratureReference:2460026] Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits [LiteratureReference:2460049] PTEN-deficient cancers depend on PIK3CB [LiteratureReference:2460043] Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis [LiteratureReference:2327861] Dynamics of the phosphoinositide 3-kinase p110? interaction with p85? and membranes reveals aspects of regulation distinct from p110? [LiteratureReference:2460061] PI 3-kinase and cancer: changing accents
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PI3K gain of function mutants phosphorylate PIP2 to PIP3
normalReaction	[Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
releaseDate	2012-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2394007
summation	[Summation:2399840] Constitutively active PI3K complex produces PIP3 in the abse...

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(hasEvent)

[Pathway:R-HSA-2219530] Constitutive Signaling by Aberrant PI3K in Cancer

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