Reactome | Phosphorylation of PIP2 to PIP3 by PI3K

Schema > Reaction > Entries

Phosphorylation of PIP2 to PIP3 by PI3K Show undefined attributes

catalystActivity	[CatalystActivity:10046341] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10046343
displayName	Phosphorylation of PIP2 to PIP3 by PI3K
eventOf	[Pathway:R-MMU-2730905] Role of LAT2/NTAL/LAB on calcium mobilization - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-202164] Translocation of PDK1 to Plasma membrane - Mus musculus
inferredFrom	[Reaction:R-HSA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of PIP2 to PIP3 by PI3K
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-MMU-2730842] PI3K associates with phosphorylated GAB2 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2730870
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2730905] Role of LAT2/NTAL/LAB on calcium mobilization
(precedingEvent)	[Reaction:R-MMU-202164] Translocation of PDK1 to Plasma membrane
(inferredTo)	[Reaction:R-HSA-2730870] Phosphorylation of PIP2 to PIP3 by PI3K

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