Reactome | PTEN dephosphorylates PIP3

Schema > Reaction > Entries

PTEN dephosphorylates PIP3 Show undefined attributes

authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:199445] phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of PTEN [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:199435] Jassal, B, 2007-07-10 12:01:00
crossReference	[DatabaseIdentifier:12667420] RHEA:25017
dbId	199456
deleted	[Deleted:8948124] Deletion of instance: 202371 [Deleted:8863125] Deletion of instance: 1676191
diseaseReaction	[FailedReaction:R-HSA-2317387] PTEN cancer mutants do not dephosphorylate PIP3 - Homo sapiens
displayName	PTEN dephosphorylates PIP3
eventOf	[Pathway:R-HSA-199418] Negative regulation of the PI3K/AKT network - Homo sapiens [Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Homo sapiens [Reaction:R-HSA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:263612] negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1675887] Membrane-binding and activation mechanism of PTEN [LiteratureReference:199432] The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate [LiteratureReference:1676004] The lipid phosphatase activity of PTEN is critical for its tumor supressor function [LiteratureReference:2317505] Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association [LiteratureReference:8948103] Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PTEN dephosphorylates PIP3 PI(3,4,5)P3 is dephosphorylated to PI (4,5)P2 by PTEN at the plasma membrane
orthologousEvent	[Reaction:R-BTA-199456] PTEN dephosphorylates PIP3 - Bos taurus [Reaction:R-SSC-199456] PTEN dephosphorylates PIP3 - Sus scrofa [Reaction:R-DRE-199456] PTEN dephosphorylates PIP3 - Danio rerio [Reaction:R-XTR-199456] PTEN dephosphorylates PIP3 - Xenopus tropicalis [Reaction:R-GGA-199456] PTEN dephosphorylates PIP3 - Gallus gallus [Reaction:R-DME-199456] PTEN dephosphorylates PIP3 - Drosophila melanogaster [Reaction:R-CEL-199456] PTEN dephosphorylates PIP3 - Caenorhabditis elegans [Reaction:R-DDI-199456] PTEN dephosphorylates PIP3 - Dictyostelium discoideum [Reaction:R-SCE-199456] PTEN dephosphorylates PIP3 - Saccharomyces cerevisiae [Reaction:R-CFA-199456] PTEN dephosphorylates PIP3 - Canis familiaris [Reaction:R-RNO-199456] PTEN dephosphorylates PIP3 - Rattus norvegicus [Reaction:R-MMU-199456] PTEN dephosphorylates PIP3 - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-198266] PI3K produces PIP3 and other phosphatidyl inositides - Homo sapiens [Reaction:R-HSA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane - Homo sapiens [Reaction:R-HSA-1675773] PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane - Homo sapiens [Reaction:R-HSA-2316434] PI3K phosphorylates PIP2 to PIP3 - Homo sapiens [BlackBoxEvent:R-HSA-2321904] PTEN mRNA translation negatively regulated by microRNAs - Homo sapiens [BlackBoxEvent:R-HSA-8944497] PTEN mRNA translation is negatively regulated by microRNAs - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37 [InstanceEdit:2247963] Wakelam, Michael, 2012-05-14 [InstanceEdit:2463860] Thorpe, Lauren, 2012-08-13 [InstanceEdit:2463859] Yuzugullu, Haluk, 2012-08-13 [InstanceEdit:2463854] Zhao, Jean J, 2012-08-13 [InstanceEdit:8948085] Leslie, Nicholas, 2016-09-30 [InstanceEdit:8948084] Kriplani, Nisha, 2016-09-30
revised	[InstanceEdit:2422427] Orlic-Milacic, M, 2012-07-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-199456
summation	[Summation:199419] At the plasma membrane, phosphatidylinositol-3,4,5-trisphosp...
updateTrackers	[UpdateTracker:9788378] Update Tracker - [Reaction:199456] PTEN dephosphorylates PIP3 - v42:[modifyText] [UpdateTracker:9782099] Update Tracker - [Reaction:199456] PTEN dephosphorylates PIP3 - v59:[addLiteratureReference, modifyText] [UpdateTracker:9783014] Update Tracker - [Reaction:199456] PTEN dephosphorylates PIP3 - v57:[addLiteratureReference, modifyText]

Referrals

(precedingEvent)	[Reaction:R-HSA-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane [Reaction:R-HSA-1855177] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane [Reaction:R-HSA-1676048] PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane [Reaction:R-HSA-1855221] PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane [Reaction:R-HSA-1676177] PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane
(hasEvent)	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane [Pathway:R-HSA-202424] Downstream TCR signaling [Pathway:R-HSA-199418] Negative regulation of the PI3K/AKT network
(normalReaction)	[FailedReaction:R-HSA-2317387] PTEN cancer mutants do not dephosphorylate PIP3
(replacementInstances)	[Deleted:8948124] Deletion of instance: 202371 [Deleted:8863125] Deletion of instance: 1676191
(updatedInstance)	[UpdateTracker:9788378] Update Tracker - [Reaction:199456] PTEN dephosphorylates PIP3 - v42:[modifyText] [UpdateTracker:9782099] Update Tracker - [Reaction:199456] PTEN dephosphorylates PIP3 - v59:[addLiteratureReference, modifyText] [UpdateTracker:9783014] Update Tracker - [Reaction:199456] PTEN dephosphorylates PIP3 - v57:[addLiteratureReference, modifyText]

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