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Schema
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Reaction
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Entries
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3
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authored
[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity
[CatalystActivity:5655340] phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
crossReference
[DatabaseIdentifier:11880454] Rhea:21292
dbId
5655235
disease
[Disease:1500689] cancer
[Disease:2032940] bone development disease
displayName
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3
edited
[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus
[EntityFunctionalStatus:5655300] gain_of_function of Activated FGFR4 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
eventOf
[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
[LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
[LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
[LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3
[LiteratureReference:1679952] PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder
[LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins
[LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3
normalReaction
[Reaction:R-HSA-5654717] FGFR4-associated PI3K phosphorylates PIP2 to PIP3
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
releaseDate
2012-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5655235
summation
[Summation:1384553] Once recruited to the activated receptor, PI3K phosphorylate...
Referrals
(hasEvent)
[Pathway:R-HSA-5655291] Signaling by FGFR4 in disease
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