Reactome | Translocation of PLC-gamma1 to PIP2

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Translocation of PLC-gamma1 to PIP2 Show undefined attributes

authored	[InstanceEdit:211006] Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10
category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:202250] Garapati, P V, 2007-10-29 14:08:25
dbId	202354
displayName	Translocation of PLC-gamma1 to PIP2
eventOf	[Pathway:R-HSA-202433] Generation of second messenger molecules - Homo sapiens
followingEvent	[Reaction:R-HSA-202407] PLC-gamma1 hydrolyses PIP2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-202357] p-Y771,Y783,Y1254-PLCG1 [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202392] The mechanism of phospholipase C-gamma1 regulation
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Translocation of PLC-gamma1 to PIP2
orthologousEvent	[Reaction:R-PFA-202354] Translocation of PLC-gamma1 to PIP2 - Plasmodium falciparum [Reaction:R-SCE-202354] Translocation of PLC-gamma1 to PIP2 - Saccharomyces cerevisiae [Reaction:R-SPO-202354] Translocation of PLC-gamma1 to PIP2 - Schizosaccharomyces pombe [Reaction:R-DDI-202354] Translocation of PLC-gamma1 to PIP2 - Dictyostelium discoideum [Reaction:R-CEL-202354] Translocation of PLC-gamma1 to PIP2 - Caenorhabditis elegans [Reaction:R-DME-202354] Translocation of PLC-gamma1 to PIP2 - Drosophila melanogaster [Reaction:R-GGA-202354] Translocation of PLC-gamma1 to PIP2 - Gallus gallus [Reaction:R-XTR-202354] Translocation of PLC-gamma1 to PIP2 - Xenopus tropicalis [Reaction:R-DRE-202354] Translocation of PLC-gamma1 to PIP2 - Danio rerio [Reaction:R-SSC-202354] Translocation of PLC-gamma1 to PIP2 - Sus scrofa [Reaction:R-BTA-202354] Translocation of PLC-gamma1 to PIP2 - Bos taurus [Reaction:R-CFA-202354] Translocation of PLC-gamma1 to PIP2 - Canis familiaris [Reaction:R-RNO-202354] Translocation of PLC-gamma1 to PIP2 - Rattus norvegicus [Reaction:R-MMU-202354] Translocation of PLC-gamma1 to PIP2 - Mus musculus
output	[Complex:R-HSA-202269] Activated PLC gamma1 bound to PIP2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-213406] Disassociation of PLC-gamma1 from LAT - Homo sapiens [Reaction:R-HSA-213407] Disassociation of PLC-gamma1 from SLP-76 - Homo sapiens [Reaction:R-HSA-202248] Phosphorylation of PLC-gamma1 - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:214481] Trowsdale, J, 2008-02-26 12:02:59
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202354
summation	[Summation:202224] Activated PLA-gamma1 translocates to the plasmamembrane and ...

Referrals

(hasEvent)	[Pathway:R-HSA-202433] Generation of second messenger molecules
(precedingEvent)	[Reaction:R-HSA-202407] PLC-gamma1 hydrolyses PIP2