Reactome | Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3

Schema > Reaction > Entries

Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3 Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:5655254] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:5655319] Rothfels, Karen, 2014-12-05
crossReference	[DatabaseIdentifier:12667417] RHEA:21292 [DatabaseIdentifier:12020828] Mondo:0005497
dbId	5655290
deleted	[Deleted:5655677] Deletion of instance: 1986647
disease	[Disease:1500689] cancer [Disease:2032940] bone development disease
displayName	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5655220] gain_of_function of Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PI3K [plasma membrane]
eventOf	[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:2023821] FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival [LiteratureReference:2023811] AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor [LiteratureReference:2032931] Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation [LiteratureReference:191514] The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3 [LiteratureReference:1679952] PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder [LiteratureReference:1604434] The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins [LiteratureReference:1679958] 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3
normalReaction	[Reaction:R-HSA-5654690] FGFR1-associated PI3K phosphorylates PIP2 to PIP3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-5655263] Activated FGFR1 mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5655290
summation	[Summation:1384553] Once recruited to the activated receptor, PI3K phosphorylate...

Referrals

(replacementInstances)	[Deleted:5655677] Deletion of instance: 1986647
(hasEvent)	[Pathway:R-HSA-5655302] Signaling by FGFR1 in disease