Reactome | DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2

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DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 Show undefined attributes

catalystActivity	[CatalystActivity:10694049] 1-phosphatidylinositol-4-phosphate 5-kinase activity of ppDVL:PIP5K1B [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10694051
displayName	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2
eventOf	[Pathway:R-XTR-201688] WNT mediated activation of DVL - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-392417] PI4P [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
precedingEvent	[Reaction:R-XTR-3772434] Phosphorylated DVL recruits PIP5K1B to the plasma membrane - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-3772436
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-201688] WNT mediated activation of DVL
(inferredTo)	[Reaction:R-HSA-3772436] DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2

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