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Schema
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Reaction
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Entries
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
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authored
[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04
catalystActivity
[CatalystActivity:1250480] phosphatidylinositol-4,5-bisphosphate 3-kinase activity of NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:1250503] Orlic-Milacic, Marija, 2011-04-21
crossReference
[DatabaseIdentifier:11880424] Rhea:21292
dbId
1250462
displayName
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
edited
[InstanceEdit:1972361] Matthews, L, 2011-11-07
eventOf
[Pathway:R-HSA-1963642] PI3K events in ERBB2 signaling - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[SimpleEntity:R-ALL-179856] PI(4,5)P2 [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:1358728] Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
orthologousEvent
[Reaction:R-CEL-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Caenorhabditis elegans
[Reaction:R-DME-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Drosophila melanogaster
[Reaction:R-GGA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Gallus gallus
[Reaction:R-DRE-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Danio rerio
[Reaction:R-SSC-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Sus scrofa
[Reaction:R-BTA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Bos taurus
[Reaction:R-CFA-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Canis familiaris
[Reaction:R-RNO-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Rattus norvegicus
[Reaction:R-MMU-1250462] PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 - Mus musculus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
precedingEvent
[Reaction:R-HSA-1250189] Binding of PI3K to ERBB2:p-ERBB3 heterodimer - Homo sapiens
releaseDate
2011-12-06
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1972347] Neckers, LM, 2011-11-11
[InstanceEdit:1972346] Xu, W, 2011-11-11
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1250462
summation
[Summation:1250469] Activated PI3K complex directly bound to phosphorylated hete...
Referrals
(normalReaction)
[Reaction:R-HSA-9664664] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3
(hasEvent)
[Pathway:R-HSA-1963642] PI3K events in ERBB2 signaling
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